DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42514 and CG8008

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001137623.1	Gene:	CG8008 / 35935	FlyBaseID:	FBgn0033387	Length:	566	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	111/525 - (21%)
Similarity:	211/525 - (40%)	Gaps:	108/525 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LQWAWHVVKSTSVEPTMFLYMFAFMITSVVEQNFFLYKSCRVNRNFTEEICRNLNKPENEEFRTK 111
            |||. .|.:...:||.:|:.:|:..::..:::|..:|::|.|..::.|..|:.|      :.:..
  Fly    17 LQWE-KVFRMFYIEPVVFMLLFSHTLSGTIQRNQVIYQTCTVIFHYNESDCKQL------DVKNA 74

  Fly   112 AMLTNAWFLQWENISAHVF----------PIILALFLGSFSDRRGRKLPLLMGLVGKFFYSTMIV 166
            :...||...:.:...|::|          |....||:||:||..|||..|::.::|......|:.
  Fly    75 SAEINAIETELQPYVANLFLARTLLESIVPAFCGLFIGSWSDHYGRKPLLIVSMIGFSASFLMMA 139

  Fly   167 VNARMTTWPVQNIIY--SATLPSALTGADVAIFASCFAYISDISSLQQRTIRVTILDVIYLSAMP 229
            ....::::.|.|..:  .|.:|.:|.|.:.....:.|.:||||:..:.|..|:..::.::...:.
  Fly   140 AICELSSYYVVNPWWYIMAAVPHSLLGGNCVFSVAAFCFISDITDCKSRPYRMIFMESLFFIGLT 204

  Fly   230 MGVALGSHLFYNVFNQ----------SYADMF----------------TVNA-------SLLALA 261
            .|..|.|.::..|.:.          ::|.:|                |.||       ..:...
  Fly   205 SGSLLSSFVYAAVGSAATIGISGCIVTFATLFIIFFVPESLHFHKEQETKNAITANVEKECIDSK 269

  Fly   262 IIYTLCALKWQ---------------------------TTP------------------------ 275
            :..|.|.|:..                           .||
  Fly   270 VPITACDLQLDRVAIDCPPNFMNDEEPGKDKRMELPTPATPAMSFDDDLLAKYVERLPQKAEERK 334

  Fly   276 RQRSLRELGCCGFWGDFFDKQHVKDSLAVLVKPRKGHRRSFLIILLVSMALYTFQRDEGQ-YLYM 339
            ||.:..:....|    .|...|::|.::...|.|..|.|:.:.::.::|.|..|..|... .:|:
  Fly   335 RQEAEEQAKKAG----LFSMVHIRDMISTCFKRRDHHARAIIWLVTLAMFLSIFVFDGVMTVMYL 395

  Fly   340 YTLGKFDWDVSAYSNFKTFKSSAYVIAMLLAVPLMNKILGWRDTTIIFIGTWAHSIARLFFYFAT 404
            :...||.|.|..|:.|:|......:|..|:...::.|:......|:..:..::..:..|...|||
  Fly   396 FVREKFHWTVRDYTFFETVSHLVPMIGALIGFLILRKVFRLSVVTLALLAFFSEILNNLAKGFAT 460

  Fly   405 NTDLLYAGAVVCSLGPIVGPMIRAMTSKIVPTSERGKVFALLSVCDNAVPFISGVCYSQLYRRTQ 469
            ....:|....:.....|.|||.|.:.|.|||.|:.||:|::.:|..:..||::...|:.:|:|:.
  Fly   461 MPWHMYLSVTLGVFRSISGPMCRTIVSNIVPPSDLGKIFSIKNVLQSFAPFVAAPLYTLIYKRSL 525

  Fly   470 NTNHG 474
            .|..|
  Fly   526 TTYPG 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	88/425 (21%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	91/430 (21%)
CG8008	NP_001137623.1	MFS	101..547	CDD:119392	92/434 (21%)
		MFS_1	101..>261	CDD:284993	35/159 (22%)
		MFS_1	375..>558	CDD:284993	42/156 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458939
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	1	1.000	-	-		mtm8701
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X552
	8	7.850