DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42514 and CG31321

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_731899.1	Gene:	CG31321 / 318681	FlyBaseID:	FBgn0051321	Length:	601	Species:	Drosophila melanogaster

Alignment Length:	602	Identity:	129/602 - (21%)
Similarity:	234/602 - (38%)	Gaps:	138/602 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 NSEDNENSASGTVREQRDEAAGRTVLQWAWHVVKSTSVEPTMFLYMFAFMITSVVEQNFFLYKSC 86
            :|.|...:.||.|    |........|..|.......:||..|.|..|.:..:|..|||.|.|:|
  Fly     6 SSADAAGNGSGAV----DAEPKLNYFQKLWRYRHYLVIEPFFFFYFMASVFNAVAMQNFPLDKAC 66

  Fly    87 RVNRNFTEEICRN-LNKPE------NEEFRT------------------------KAMLTNAWFL 120
            |||..:.:.:|.. |:|.|      :.:|..                        ||.| .|..|
  Fly    67 RVNLGYNKIVCDTMLDKSELGIECDDFDFENTTQGATPDLADLVIGATGFNYTVCKAEL-EAQIL 130

  Fly   121 QWENIS------AHVFPIILALFLGSFSDRRGRKLP-LLMGLVGK-FFYSTMIVVNARMTTWPVQ 177
            . .::|      |.:||:|:.||.|.::||..::.| ::|.::|: ..::..|:.:....:.|::
  Fly   131 A-ADVSGKRAPMAAIFPLIVLLFAGGWADRYNKRKPCMIMPIIGEALSFTCQIISSIFFESLPME 194

  Fly   178 NIIYSATLPSALTGADVAIFASCFAYISDISSLQQRTIRVTILDVIYLSAMP-MGVALGSHLFYN 241
            ...|...:..||.|.......:.::||:..:..:.|..|..|. .::::.:| :|..:...||..
  Fly   195 FGAYCEAIVPALFGGLTFCLMAIYSYITIATPEEDRVFRFGIF-AMFVTGVPFIGQPISGVLFTT 258

  Fly   242 V-FNQSYADMFTVNASLLALAIIYTLCALK---------------------------------WQ 272
            : :..|:|......    .:||.|.:..:|                                 ::
  Fly   259 LGYTWSFASAIVFQ----LIAIFYIIFFIKEVKTTPTTSTTANEPPPLPTSLPPKQQGADNMAYE 319

  Fly   273 TT---------------------------PRQRSLRELGCCGFWGDFFDKQHVKDSLAVLVKPRK 310
            ||                           |::..|:||         ||...|.|.:...:..|.
  Fly   320 TTNLDELQGNKNVNFQLTPQMEPKVEVVPPKRSLLKEL---------FDPTLVLDCIRFPLVKRP 375

  Fly   311 GHRRSFLIILLVSMALYTFQRD-EGQYLYMYTLGKFDWDVSAYSNFKTFKSSAYVIAMLLAVPLM 374
            .:.|..||:||.:..|...... |..|.|.:||.|..|:.:.:|.:.|..|.|.::...:...::
  Fly   376 NNGRMLLILLLCAYFLTVGPTSGENDYWYRFTLKKLAWNGNDFSIYLTLSSGAALVGTFIGTAIL 440

  Fly   375 NKILGWRDTTIIFIGTWAHSIARLFFYFATNTDLLYAGAVV---CSLGPIVGPMIRAMTSKIVPT 436
            :|:|...|:.|..:...:...:|:.|.|:::|...|...||   .||..|.   |:.:.|.||..
  Fly   441 SKLLKVSDSMIGMLSALSIVCSRVLFAFSSSTASFYVAGVVDMFVSLRVIA---IKTIGSSIVAG 502

  Fly   437 SERGKVFALLSVCDNAVPFISGVCYSQLYRRTQNTNHG-----GNVFILTIATQIAVFVMILCLH 496
            .|..|::::..:.:....||....:|::|:.|.::..|     |.:|.:.     .|.|.::|..
  Fly   503 DELSKMYSIFGISEPIAQFIFPPIFSEIYKSTVDSFPGAIWLFGEIFYIP-----NVLVFVVCYF 562

  Fly   497 IVLGKNSLAVPEVPEKE 513
            ::..:.:.....|.|.|
  Fly   563 LLRRRKANEEKSVVEME 579

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	82/396 (21%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	88/435 (20%)
CG31321	NP_731899.1	MFS	141..>271	CDD:119392	29/130 (22%)
		MFS_1	143..>271	CDD:284993	28/128 (22%)
		MFS	<379..559	CDD:119392	47/187 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458944
Domainoid	1	1.000	91	1.000	Domainoid score	I4859
eggNOG	1	0.900	-	-		E1_KOG2816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	74	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23507
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.900