DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42514 and Slc46a2

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_066395.3	Gene:	Slc46a2 / 30936	MGIID:	1353616	Length:	479	Species:	Mus musculus

Alignment Length:	509	Identity:	118/509 - (23%)
Similarity:	205/509 - (40%)	Gaps:	86/509 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 AGRTVLQWAWHVVKSTSVEPTMFLYMFAFMITSVVEQNFFLYKSCRVNRNFTEEICRNLNKPENE 106
            :|..|..|...||.||.|..:  ||....::  ||:::|      :.....:.....|.:..|.:
Mouse    14 SGFRVRTWIEPVVASTQVAGS--LYDAGLLL--VVKESF------KSEAGGSSNYSANQSLVEYQ 68

  Fly   107 EFRTKAMLTNAWFLQWENISAHVFPIILALFLGSFSDRRGRKLPLLMGLVGKFFYSTMIVVNARM 171
            |.:.:..::|  |....|:...:.|::.|..||..|||..||:.:...::| |..|.:.::...|
Mouse    69 EDQQQKAISN--FNIIYNLVLGLTPLLSAYGLGWLSDRYHRKISICTAMLG-FLLSRIGLLLKVM 130

  Fly   172 TTWPVQNIIYSATLPSALTGADVAIFASCFAYISDISSLQQRTIRVTILDVIYLSAMPMGVALGS 236
            ..|||: ::|.|...:.|.|:..|.::...|..|...|..:|::|:.::|::...|...|.....
Mouse   131 LDWPVE-VMYGAAALNGLCGSFSAYWSGVMALGSLGCSEGRRSVRLILIDLVLGLAGFSGSMASG 194

  Fly   237 HLFYNVFNQSYADMFTVNASL--LALAIIYTLCALKW-QTTPRQRSLRELGCCGFWG-------D 291
            |||..:...|...:.....|:  .|.|:.|:|..||. ::.|.:.........|..|       |
Mouse   195 HLFKQIVGHSAQGLLLTACSVGCAAFALFYSLFVLKVPESKPNKVHPTVDTVSGMMGTYRTLDPD 259

  Fly   292 FFDKQHVKDSLAVLVKPR-----KGHRRSFLIILLVSMALYTFQRDEGQYLYMYTLGKFD----- 346
            ..|||:|..:      ||     |..:|..:.:|.|...:|.          :..:|..|
Mouse   260 QQDKQNVPRN------PRTPGKGKSSQREVVALLFVGAIIYD----------LAAVGTVDVMALF 308

  Fly   347 -------WD--------VSAYSNFKTFKSSAYVIAMLLAVPLMNKILGWRDTTIIFIGTWAHSIA 396
                   |:        .|.|..|         |...|.|.:.::.  :||||:|.||..:....
Mouse   309 VLKEPLHWNQVQLGYGMASGYIIF---------ITSFLGVLVFSRC--FRDTTMIIIGMLSFGSG 362

  Fly   397 RLFFYFATNTDLLYAGAVVCSLGPIVGPMIRAMTSKIVPTSERGKVFALLSVCDNAVPFISGVCY 461
            .|...|...|.:.|....:.....|....||:..||::..|..||:|.:|.:|......::...|
Mouse   363 ALLLAFVKETYMFYIARAIMLFALIPITTIRSAMSKLIKDSSYGKIFVILQLCLTLTGVVTSTIY 427

  Fly   462 SQLYRRTQNTNHGGNVFILTIATQIAVFVMILCLHIVLGKNSLAVPEVPEKESG 515
            :::|:.|.: ...|..|:|   :....|:.|:.:.:|      |..:||..:.|
Mouse   428 NKIYQLTLD-KFIGTCFVL---SSFLSFLAIVPIGVV------AYKQVPRSQQG 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	86/363 (24%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	93/397 (23%)
Slc46a2	NP_066395.3	MFS	86..455	CDD:119392	93/401 (23%)
		MFS_1	88..422	CDD:284993	86/362 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	255..277		7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844275
Domainoid	1	1.000	70	1.000	Domainoid score	I9497
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8701
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5729
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.870