DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42514 and Slc46a2

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001100122.1	Gene:	Slc46a2 / 298034	RGDID:	1310485	Length:	480	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	117/515 - (22%)
Similarity:	208/515 - (40%)	Gaps:	85/515 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 AGRTVLQWAWHVVKSTSVEPTMFLYMFAFMITSVVEQNFFLYKSCRVNRNFTEEICRNLNKPENE 106
            :|..|..|...||.||.|..:  ||....::  |::::|  ....|.:.|::    .|.:..|.:
  Rat    14 SGFRVRTWIEPVVASTQVAGS--LYDTGLLL--VLKESF--ASDARDSSNYS----ANQSLGERQ 68

  Fly   107 EFRTKAMLTNAWFLQWENISAHVFPIILALFLGSFSDRRGRKLPLLMGLVGKFFYSTMIVVNARM 171
            |.:.:..::|.:.:.  |:...:.|::.|..||..|||..||:.:...::| |..|.:.::...|
  Rat    69 EDQQQKAISNFYIIY--NLVVGLTPLLSAYVLGWLSDRYHRKISICTAMLG-FLLSRIGLLLKVM 130

  Fly   172 TTWPVQNIIYSATLPSALTGADVAIFASCFAYISDISSLQQRTIRVTILDVIYLSAMPMGVALGS 236
            ..||:: ::|.|...:.|.|...|.::...|..|...|..:|::|:.::|::...|...|.....
  Rat   131 LDWPLE-VMYGAAALNGLCGGFSAYWSGVMALGSLSCSQSRRSVRLILIDLVLGLAGFCGSMASG 194

  Fly   237 HLFYNVFNQSYADMFTVNASL--LALAIIYTLCALKWQ---TTPRQRSLRELGCCGFWG------ 290
            |||..:...|...:.....|:  .|.|:.|:|..||..   :.|.:.........|..|
  Rat   195 HLFKQIVGHSAQGLLLTACSVGCAAFALFYSLFVLKVPEAVSKPNKVHPTVDTVSGMMGTYRTLD 259

  Fly   291 -DFFDKQHVKDSLAVLVKPRKGHRR---SFLIILLVSMALYTFQRDEGQYLYMYTLGKFD----- 346
             |..||.:::.:     .|..|..:   :.:.:|.|...:|.          :..:|..|
  Rat   260 PDQQDKPNIQAN-----PPTPGKEKPSQAIIALLFVGAIVYD----------LAVVGTLDVMALF 309

  Fly   347 -------WD--------VSAYSNFKTFKSSAYVIAMLLAVPLMNKILGWRDTTIIFIGTWAHSIA 396
                   |:        .|.|..|         |...|.|.:.::.  :||||:|.||..:....
  Rat   310 VLKDPLHWNQVQLGYGMASGYIIF---------ITSFLGVLVFSRY--FRDTTMIIIGMVSFGSG 363

  Fly   397 RLFFYFATNTDLLYAGAVVCSLGPIVGPMIRAMTSKIVPTSERGKVFALLSVCDNAVPFISGVCY 461
            .|...|...|.:.|....|.....|....||:..||:|..|..||:|.:|.:|......::...|
  Rat   364 ALLLAFVKKTYMFYIARAVMLFALIPITTIRSAMSKLVKDSSYGKIFVILQLCLALTGVVTSTMY 428

  Fly   462 SQLYRRTQNTNHGGNVFILTIATQIAVFVMILCLHIVLGKNSLAVPEVPEKESGLISQTE 521
            :::|:.|.| ...|..|:|   :....|:.|:.:.:|      |..:||....|..:.|:
  Rat   429 NKIYQLTLN-KFAGTCFLL---SSFLSFLAIVPIGVV------AYKQVPGSRQGECADTQ 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	83/363 (23%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	91/397 (23%)
Slc46a2	NP_001100122.1	MFS	86..433	CDD:119392	84/374 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347635
Domainoid	1	1.000	71	1.000	Domainoid score	I9200
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44504
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.850