DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42514 and Slc46a3

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_001020139.1	Gene:	Slc46a3 / 288454	RGDID:	1307594	Length:	461	Species:	Rattus norvegicus

Alignment Length:	488	Identity:	108/488 - (22%)
Similarity:	209/488 - (42%)	Gaps:	57/488 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 VKSTSVEPTMFLYMFAFMITSVVEQNFFLYKSCRVNRNFTEEICRNLNKPE----------NEEF 108
            :|.:.:||.:.||.||..:|..:...:...:......|:|.....|:::.|          .||.
  Rat     1 MKISFIEPAILLYAFAMTLTIPLTAQYVYRRIWEETGNYTFTSSSNVSECEQNKSSSTFAFQEEV 65

  Fly   109 RTKAMLTNAWFLQWENISAHVFPIILALFLGSFSDRRGRKLPLLMGLVGKFFYSTMIVVNARMTT 173
            :.||.|   :.||.| ||..:..::....|.|.||..|||||:::..:|....:..:...:....
  Rat    66 QKKASL---FSLQVE-ISGLIPGLVSTFMLLSSSDNHGRKLPMVLSSLGSLGTNLWLCAMSYFDL 126

  Fly   174 WPVQNIIYSATLPSALTGADVAIFASCFAYISD-ISSLQQRTIRVTILDVIYLSAMPMGVA---L 234
             |:| ::.::|...||.|.....:.:|||||.| ....:.|.||:.:||.:      :||.   .
  Rat   127 -PLQ-LLVASTFIGALFGNYTTFWGACFAYIVDQEKEYKHRIIRIAVLDFM------LGVVTGLT 183

  Fly   235 GSHLFYNVFNQSYADMFTVNASLLALAIIYTLCALKWQTTPRQRSLRELGCCGFWGDFFDKQHVK 299
            |....|.:....:|..:.:.|.::.:.:.|.|..|..........:..:.|.....|.|.:.:
  Rat   184 GLSSGYFIRELGFAWSYFIIAVVVLVNLAYILFFLSDPIKESSSQIVTMSCSESLKDLFYRTY-- 246

  Fly   300 DSLAVLVKPRKGHRRSFLIILLVSMALYTFQRDEGQYLY-------MYTLG-KFDWDVSAYSNFK 356
                :|.|.....|||.|.:|:.::.:|.|      .::       :|.|| ...|: ..|..:.
  Rat   247 ----MLFKNGSCKRRSLLCLLIFTLVVYFF------VVFGITPVFTLYELGPPLCWN-EVYIGYG 300

  Fly   357 TFKSSAYVIAMLLAVPLMNKILGWRDTTIIFIGTWAHSIARLFFYFATNTDLLYAGAV--VCSLG 419
            :...|...::..|.:.|.:..|  :|..|.::|.:...:..:...|...|.:::...:  ..::.
  Rat   301 SALGSLSFLSSFLGIWLFSYCL--KDIHIAYVGIFTTMVGMMLTAFTRTTLMMFLVRISFFFTIM 363

  Fly   420 PIVGPMIRAMTSKIVPTSERGKVFALLSVCDNAVPFISGVCYSQLYRRTQNTNHGGNVFILTIAT 484
            |:  .::|:|.||:|.::|:|.:||.::..:......|...|:.:|..|. ..:.|.||:|:...
  Rat   364 PL--SILRSMLSKVVHSTEQGVLFACIAFLETLGGVTSTSAYNGIYSATV-AWYPGFVFLLSAGL 425

  Fly   485 QIAVFV---MILCLHIVLGKNSLAVPEVPEKES 514
            .:...|   |:.|:....|..:|.:.:.|.:.:
  Rat   426 LVLPAVSLCMVKCIGWEEGSYTLLIHDEPSEHT 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	72/342 (21%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	82/379 (22%)
Slc46a3	NP_001020139.1	MFS	3..437	CDD:421695	103/463 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	71	1.000	Domainoid score	I9200
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44504
orthoMCL	1	0.900	-	-		OOG6_100739
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X552
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.830