DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42514 and slc-46A

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	NP_500781.2	Gene:	slc-46A / 189356	WormBaseID:	WBGene00021159	Length:	469	Species:	Caenorhabditis elegans

Alignment Length:	496	Identity:	105/496 - (21%)
Similarity:	208/496 - (41%)	Gaps:	53/496 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 VKSTSVEPTMFLYMFAFMITSVVEQNFFLYKSCRVNRNFTEEICRNLNKPENEEFRTKAMLTNAW 118
            ::...:|..:||||....:...|.||....|.|.:.....|..|||::...::: ..:|...:.:
Worm     5 LRMLGMEIPLFLYMLGSYLNYPVFQNLIYEKECLIKYQQNETFCRNVSAYYDDK-DIQAAANHFY 68

  Fly   119 FLQWENISAHVFPIILALFLGSFSDRRGRKLPLLMGLVGKFFYSTMIVVNARMTTWPVQNIIYSA 183
            |:  .:::.....::..|.||:.:|....|:||::..:|    ..:..:|....::.:...:|..
Worm    69 FI--SSLTLLCPSLVTTLLLGAATDYWSIKIPLIIPYIG----CILGTINYVFQSYFIHTSVYFL 127

  Fly   184 TLPSA---LTGADVAIFASCFAYISDISSLQQRTIRVTILDVIYLSAMPMGVALGSHLFYNVFNQ 245
            .:..|   |.|..:||.::...|....|.|:.|:.|:..::    .|:.:|..:|..|...:...
Worm   128 LISDALFGLCGGFIAIISTTLTYGVKTSMLRYRSYRIAGVE----GAIGLGGTVGFALSGTIREA 188

  Fly   246 -SYADMFTVNASLLALAIIYTLCALKWQTTPRQRSLRELGCCGFWGDFFDKQHVKDSLAVLVKPR 309
             .||..|.:...|..||::|.|...|.......|...........|        |..:||:   |
Worm   189 CGYAVTFLIILGLQLLALLYLLGLAKETKFEPVRPDEHTSLISTTG--------KQLVAVI---R 242

  Fly   310 KGHR-----RSFLIILLVSMALYTFQR------DEGQYLYM-YTLGKFDWDVSAYSNFKTFKSSA 362
            :.:|     |.|.::|::::..:..:.      .:.||.|: |   |..|....|..|.......
Worm   243 EFYRVITKSRQFRLLLILNLLAFGLEMLVFSGLSDIQYSYLRY---KLQWGDKKYGWFSGLSYGI 304

  Fly   363 YVIAMLLAVPLMN-KILGWRDTTIIFIGTWAHSIARLFFYFATNTDLLYAGAVVCSLGPIVGPMI 426
            ...|:|...||:. |::.  |..:..:|.:...|:...|.|..|..:.|:.||:......|....
Worm   305 TTAAVLFLYPLLRMKLMS--DGMLATLGLFFKMISLFMFAFLQNEVMAYSIAVIVMFNRFVSTGF 367

  Fly   427 RAMTSKIVPTSERGKVFALLSVCDNAVPFISGVCYSQLYRRTQNTNHGGNVFILTIATQIAVFVM 491
            ||..|.::...|:||:|:::|:.:.....::...|:.:|..|. |...|.:::::..|      :
Worm   368 RAFISSLIDMQEQGKIFSVISLLEGITTLVATSIYNNVYPNTL-TFFPGLLYLISAVT------L 425

  Fly   492 ILCLHIVLGKNSLAVPEVPEKESGLISQTEAVLEAE--IEE 530
            ::.|.||...:.:.....||...|:::....|::.:  ||:
Worm   426 LIPLAIVSTSDFVVRTHRPEVSEGILNSRNDVIDEDGSIED 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	74/345 (21%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	80/379 (21%)
slc-46A	NP_500781.2	MFS_SLC46	7..436	CDD:340944	99/462 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	91	1.000	Domainoid score	I4859
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14635
orthoMCL	1	0.900	-	-		OOG6_100739
Panther	1	1.100	-	-	O	PTHR23507
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5729
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.860