DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42514 and AgaP_AGAP004562

DIOPT Version :9

Sequence 1:	NP_730171.1	Gene:	CG42514 / 8674108	FlyBaseID:	FBgn0260388	Length:	533	Species:	Drosophila melanogaster
Sequence 2:	XP_562320.4	Gene:	AgaP_AGAP004562 / 1274703	VectorBaseID:	AGAP004562	Length:	557	Species:	Anopheles gambiae

Alignment Length:	495	Identity:	122/495 - (24%)
Similarity:	239/495 - (48%)	Gaps:	27/495 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RNSRSSENSEDNENSASGTVREQRDEAAGRTVLQWAWHVVKSTSVEPTMFLYMFAFMITSVVEQN 79
            ||.:..:.||...:...  |:|::..::.|   :...:..::.:|||.:..|:...::..:..||
Mosquito     2 RNLQPPKGSEKVADELK--VKEKKSPSSLR---EKYLYFKRNITVEPMLACYIMPSVLAGLATQN 61

  Fly    80 FFLYKSCRVNRNFTEEICRNLNKPENEEFRTKAMLTN---AWFLQWENISAHVFPIILALFLGSF 141
            ..|.|:||||..:.:.||..|.:.:...:..:..:..   |....|:.:.....|.:|.||.||:
Mosquito    62 LNLEKACRVNLGYGDVICDALTRRDTANYTHEEEMVQHLVARMAGWKTVLQSALPCMLILFWGSW 126

  Fly   142 SDRRGRKLP-LLMGLVGKFFYSTMIVVNARMTTWPVQNIIYSATLPSALTGADVAIFASCFAYIS 205
            |||.||:.| :|:.::|:|..:..:::.....:.|::....:..|..||||....:|...|:||:
Mosquito   127 SDRHGRRKPCMLIPIIGEFMTAIGLILCTYFKSVPMEVAGITEALFPALTGGWFTMFMGVFSYIA 191

  Fly   206 DISSLQQRTIRVTILDVIYLSAMPMGVALGSHL-----FYNVFNQSYADMFTVNASLLALAIIYT 265
            |:::.::||:|:.|:::.:...:|:|:|....|     ||.|        |:::|||..:|..|.
Mosquito   192 DVTTTEERTLRIGIVNLCFSLGVPIGMAFSGILLKQIGFYGV--------FSISASLYLVAFFYG 248

  Fly   266 LCALKWQTTPRQRSLRELGCCGFWGDFFDKQHVKDSLAVLVKPRKGHRR-SFLIILLVSMALYTF 329
            :..:|......::........|...||||::||.::..|..|..:..|| ..:::::|.|.:...
Mosquito   249 VFVVKEVDILNEKQRLRAQEKGLLADFFDREHVMETFRVAFKIGERQRRLRVIMLMIVVMVVIGP 313

  Fly   330 QRDEGQYLYMYTLGKFDWDVSAYSNFKTFKSSAYVIAMLLAVPLMNKILGWRDTTIIFIGTWAHS 394
            ...|...:|::|..:|:|....:|.|.|:.....:|..|.:|.:.:.:|...|..|..:...:..
Mosquito   314 LHGEMAVIYLFTRYRFNWSEVEFSFFSTYGMLTGLIGTLFSVGVFSHLLKIDDALIGVMSCMSKI 378

  Fly   395 IARLFFYFATNTDLLYAGAVVCSLGPIVGPMIRAMTSKIVPTSERGKVFALLSVCDNAVPFISGV 459
            ::...:.||..|..||.|.:|..|.......:|::.||:|.:.|.|||.:|..|.:..:|.:...
Mosquito   379 LSSFVYAFAVTTWQLYLGPIVEMLNGTSFISMRSIASKLVASDELGKVNSLFGVAEALMPLVYAP 443

  Fly   460 CYSQLYRRTQNTNHGGNVFIL---TIATQIAVFVMILCLH 496
            .|:.:|..:.|...|. .|:|   ..:..:.:|:.:..:|
Mosquito   444 LYTTVYTLSINVLPGA-FFLLGGALTSPAVVIFLWMYRVH 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	90/335 (27%)
CG42514	NP_730171.1	MFS	132..495	CDD:119392	96/372 (26%)
AgaP_AGAP004562	XP_562320.4	MFS	98..479	CDD:119392	99/389 (25%)
AgaP_AGAP004562	XP_562320.4	MFS_1	99..440	CDD:284993	92/348 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48502
OrthoDB	1	1.010	-	-		D333052at33208
OrthoFinder	1	1.000	-	-		FOG0001349
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X552
TreeFam	0	0.000	Not matched by this tool.
	6	5.830