Protein Alignment CG42514 and ADCY5

DIOPT Version :9

• Sequence 1: NP_730171.1
• Gene: CG42514 / 8674108
• FlyBaseID: FBgn0260388
• Length: 533
• Species: Drosophila melanogaster
• Sequence 2: NP_001365188.1
• Gene: ADCY5 / 111
• HGNCID: 236
• Length: 1286
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 89/521 - (17%)
• Similarity: 163/521 - (31%)
• Gaps: 234/521 - (44%)

  Fly    15 RNSRSSENSEDNENSASGTVREQRDEAAGRTVLQWAWHVVKSTSVEPTMFLYMFAFMITSVVEQN 79
            :|::.|.|.||           :.||..||        .:.:.|::.....::..|::|
Human   704 KNAQESANPED-----------EVDEFLGR--------AIDARSIDRLRSEHVRKFLLT------ 743

  Fly    80 FFLYKSCRVNRNFTE-EICRNLNKPENEEFRTKAMLTNAWFLQWENISAHVFPIILALFLGSFSD 143
                        |.| ::.:..:|..::.|.......:..||....:...:.|  .::|:.|
Human   744 ------------FREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQITIVP--HSIFMLS--- 791

  Fly   144 RRGRKLPLLMGLVGKFFYSTMIVVNARMTTWPVQNIIYSATLPSALTGADVAIFASCFAYISDIS 208
                            ||.|..::   :|.....::|||.          |.:|.      |.:.
Human   792 ----------------FYLTCSLL---LTLVVFVSVIYSC----------VKLFP------SPLQ 821

  Fly   209 SLQQRTIR---------VTILDVIYLSAMPMGVALGSHLFYNVFNQSYADMF------------T 252
            :|.::.:|         |..:.:::|:|           |.|:|..:..|:.            .
Human   822 TLSRKIVRSKMNSTLVGVFTITLVFLAA-----------FVNMFTCNSRDLLGCLAQEHNISASQ 875

  Fly   253 VNASLLA-LAIIYTL------CALKWQTTPRQRSLRELGCCGFWGDFFDKQHVKDSLAVLVKPRK 310
            |||..:| .|:.|:|      |...|..            |.| .::|       :.:||
Human   876 VNACHVAESAVNYSLGDEQGFCGSPWPN------------CNF-PEYF-------TYSVL----- 915

  Fly   311 GHRRSFLIILLVSMALYTFQRDEGQYLYMYTLGKFDWDVSAYSNFKTFKSSAYVIAMLLAVPLMN 375
                  |.:|..|:           :|.:..:||                    :.::||:.|:.
Human   916 ------LSLLACSV-----------FLQISCIGK--------------------LVLMLAIELIY 943

  Fly   376 KILGWRDTTIIFIGTWAHSIARLFFYFATNTDLLYAGAVVCSLGPIVGPMIRAMTSKIVPTSERG 440
            .::.......:|                .|.|||                   :|:..:.....|
Human   944 VLIVEVPGVTLF----------------DNADLL-------------------VTANAIDFFNNG 973

  Fly   441 KVFALLSVCDN--------AVPFISGVCYSQLYRRTQNTNHGGNVFILTIATQ--IAVFVMILCL 495
            .  :..|:|:|        ...|.|||       :.|:..|...| .|.:.|.  |:|||:.|.|
Human   974 T--SQWSLCENLRHRRMEAGTYFPSGV-------KEQSPEHATKV-ALKVVTPIIISVFVLALYL 1028

  Fly   496 H 496
            |
Human  1029 H 1029

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42514	NP_730171.1	MFS_1	129..458	CDD:284993	56/364 (15%)
		MFS	132..495	CDD:119392	68/400 (17%)
ADCY5	NP_001365188.1	AC_N	1..458	CDD:318454
		Guanylate_cyc	460..633	CDD:306677
		DUF1053	668..760	CDD:399378	15/92 (16%)
		Guanylate_cyc	1087..1281	CDD:306677

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4862
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950