Protein Alignment CanA-14F and PPP3CC

DIOPT Version :9

• Sequence 1: NP_001245717.1
• Gene: CanA-14F / 8674098
• FlyBaseID: FBgn0267912
• Length: 584
• Species: Drosophila melanogaster
• Sequence 2: NP_001230903.1
• Gene: PPP3CC / 5533
• HGNCID: 9316
• Length: 521
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 380/520 - (73%)
• Similarity: 437/520 - (84%)
• Gaps: 35/520 - (6%)

  Fly    80 KRSTISTKERVIDSVAFPPSRKLTCADVFDARTGKPQHDVLKQHFILEGRIEESAALRIIQEGAT 144
            :|..:||.:|||.:|.|||:::||..:||:  .|||:.||||.|.:.|||:||..||:||.:||.
Human     4 RRFHLSTTDRVIKAVPFPPTQRLTFKEVFE--NGKPKVDVLKNHLVKEGRLEEEVALKIINDGAA 66

  Fly   145 LLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWS 209
            :||.|||||:::||:||||||||||:|||||||:||||:.|:|||||||||||||||||||||||
Human    67 ILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWS 131

  Fly   210 LKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHG 274
            |||.:|:|||||||||||||||:||||||||:|||||:||||||:.|||||||||:|||||||||
Human   132 LKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHG 196

  Fly   275 GLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAAC 339
            |:||||..|:|||:||||.|||||||:||||||||.||:||||..:.||||:||||||||||.|.
Human   197 GMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAV 261

  Fly   340 CDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMN 404
            |:||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
Human   262 CEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMN 326

  Fly   405 IRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEA---- 465
            |||||||||||||||||||||||||||||||||||||||||||||||        :|||||
Human   327 IRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL--------ISDDEAEDHY 383

  Fly   466 ---------ALRKEVIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSL- 520
                     .:|||:||||||||||||||||:||:||||||.||||||||.||||.||||||::
Human   384 IPSYQKGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIE 448

  Fly   521 ---------KNAMQGFSPNHKITSFAEAKGLDAVNERMPPRRDATPSPAEEGQKSLSAAAAAAAN 576
                     :.|::|||..|||.||.||:|||.:|||||||:|:.  .|....||:::|.:.||:
Human   449 TATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSI--HAGGPMKSVTSAHSHAAH 511

  Fly   577  576
            Human   512  511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CanA-14F	NP_001245717.1	MPP_PP2B	115..419	CDD:277361	252/303 (83%)
		PP2Ac	132..403	CDD:197547	226/270 (84%)
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	252/303 (83%)
		Catalytic. /evidence=ECO:0000305	52..343		245/290 (84%)
		PP2Ac	54..325	CDD:197547	226/270 (84%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366		21/21 (100%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	395..409		12/13 (92%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	410..417		5/6 (83%)
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	468..490		16/21 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..521		15/34 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142536
Domainoid	1	1.000	394	1.000	Domainoid score	I765
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	815	1.000	Inparanoid score	I479
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm8621
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R954
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800