DRSC/TRiP Functional Genomics Resources

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Protein Alignment CanA-14F and PPP3CA

DIOPT Version :9

Sequence 1:NP_001245717.1 Gene:CanA-14F / 8674098 FlyBaseID:FBgn0267912 Length:584 Species:Drosophila melanogaster
Sequence 2:NP_000935.1 Gene:PPP3CA / 5530 HGNCID:9314 Length:521 Species:Homo sapiens


Alignment Length:510 Identity:399/510 - (78%)
Similarity:439/510 - (86%) Gaps:30/510 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 ISTKERVIDSVAFPPSRKLTCADVFDARTGKPQHDVLKQHFILEGRIEESAALRIIQEGATLLRT 148
            :||.:||:.:|.||||.:||..:||| ..|||:.|:||.|.:.|||:|||.|||||.|||::||.
Human    11 LSTTDRVVKAVPFPPSHRLTAKEVFD-NDGKPRVDILKAHLMKEGRLEESVALRIITEGASILRQ 74

  Fly   149 EKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKIT 213
            ||.::||:|||||||||||||:|||||||:|||||.|:||||||||||||||||||||||:|||.
Human    75 EKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALKIL 139

  Fly   214 YPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP 278
            ||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   140 YPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP 204

  Fly   279 EIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFL 343
            ||:.|:|||:|||||||||:|||||:|||||||||||||..:.:|||:||||||||||.|.|:||
Human   205 EINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFL 269

  Fly   344 QNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF 408
            |:||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human   270 QHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF 334

  Fly   409 NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEAALRKEVIR 473
            |||||||||||||||||||||||||||||||||||||||||||.:|  |:......||.||||||
Human   335 NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSE--EDGFDGATAAARKEVIR 397

  Fly   474 NKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKN----------AMQGFS 528
            ||||||||||||||||||||||||.||||||||.||.|.||||||:|::          |::|||
Human   398 NKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEADEAIKGFS 462

  Fly   529 PNHKITSFAEAKGLDAVNERMPPRRDATPSPAEEGQKSLSAAAAAAANANANSIN 583
            |.||||||.||||||.:||||||||||.||                 :||.||||
Human   463 PQHKITSFEEAKGLDRINERMPPRRDAMPS-----------------DANLNSIN 500

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CanA-14FNP_001245717.1 MPP_PP2B 115..419 CDD:277361 262/303 (86%)
PP2Ac 132..403 CDD:197547 237/270 (88%)
PPP3CANP_000935.1 MPP_PP2B 41..345 CDD:277361 262/303 (86%)
Catalytic. /evidence=ECO:0000305 56..340 249/283 (88%)
SAPNY motif. /evidence=ECO:0000305|PubMed:26248042 307..311 3/3 (100%)
Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042 327..336 8/8 (100%)
Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402 341..369 27/27 (100%)
Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.31 392..406 13/13 (100%)
Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298 407..414 6/6 (100%)
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402 465..487 18/21 (86%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..521 21/43 (49%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 394 1.000 Domainoid score I765
eggNOG 1 0.900 - - E1_COG0639
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H55497
Inparanoid 1 1.050 815 1.000 Inparanoid score I479
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53795
OrthoDB 1 1.010 - - D194337at33208
OrthoFinder 1 1.000 - - FOG0000983
OrthoInspector 1 1.000 - - mtm8621
orthoMCL 1 0.900 - - OOG6_100566
Panther 1 1.100 - - LDO PTHR45673
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R954
SonicParanoid 1 1.000 - - X576
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1514.870

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