DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CanA-14F and ppp3cb

DIOPT Version :9

Sequence 1:	NP_001245717.1	Gene:	CanA-14F / 8674098	FlyBaseID:	FBgn0267912	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	XP_009305997.1	Gene:	ppp3cb / 550554	ZFINID:	ZDB-GENE-050417-406	Length:	522	Species:	Danio rerio

Alignment Length:	512	Identity:	393/512 - (76%)
Similarity:	438/512 - (85%)	Gaps:	19/512 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 ISTKERVIDSVAFPPSRKLTCADVFDARTGKPQHDVLKQHFILEGRIEESAALRIIQEGATLLRT 148
            ::..:|||.||.||.|.:|:..:|||.. |||:.|:||.|...|||:||..||||:.|||.:||.
Zfish    11 LNPTDRVIKSVPFPLSHRLSMREVFDCE-GKPRVDLLKAHLTKEGRVEEPVALRIVNEGAAILRQ 74

  Fly   149 EKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKIT 213
            ||||:||||||||||||||||:|||||||:|||||||:||||||||||||||||||||||||||.
Zfish    75 EKTMLDIEAPVTVCGDIHGQFFDLMKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWSLKIL 139

  Fly   214 YPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSP 278
            ||:||||||||||||||||||||||||||||||:|||||||||||||||||||||||||||||||
Zfish   140 YPKTLFLLRGNHECRHLTEYFTFKQECKIKYSEQVYDACMDAFDCLPLAALMNQQFLCVHGGLSP 204

  Fly   279 EIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFL 343
            |||.|:||:||||||||||||||||||||||||||||||:.|:::||:||||||||||.|.|:||
Zfish   205 EIHTLDDIKRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKSQDYFSHNTVRGCSYFYSYPAVCEFL 269

  Fly   344 QNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF 408
            |.|||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   270 QTNNLLSVIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQF 334

  Fly   409 NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEAALRKEVIR 473
            |||||||||||||||||||||||||||||||||||:|||||||| .:.:|....:.||.||||||
Zfish   335 NCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELM-NDGDEIFDANAAAARKEVIR 398

  Fly   474 NKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKN---------------- 522
            ||||||||||::|||||||||:||.||||||||.||.|.||||||:|::
Zfish   399 NKIRAIGKMAKMFSVLREESENVLTLKGLTPTGMLPSGVLSGGKQTLQSATIEAIEAVEEVKDGE 463

  Fly   523 AMQGFSPNHKITSFAEAKGLDAVNERMPPRRDATPSPA-EEGQKSLSAAAAAAANAN 578
            |::||||.||||||.||||||.:|||||||||...|.. ..|:.:::.:.....|:|
Zfish   464 AIRGFSPQHKITSFEEAKGLDRINERMPPRRDVVNSVGLSMGKMNMAESNGTDDNSN 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanA-14F	NP_001245717.1	MPP_PP2B	115..419	CDD:277361	267/303 (88%)
CanA-14F	NP_001245717.1	PP2Ac	132..403	CDD:197547	242/270 (90%)
ppp3cb	XP_009305997.1	MPP_PP2B	41..345	CDD:277361	267/303 (88%)
ppp3cb	XP_009305997.1	PP2Ac	60..329	CDD:197547	241/268 (90%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	402	1.000	Domainoid score	I693
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55497
Inparanoid	1	1.050	807	1.000	Inparanoid score	I469
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm6407
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.840