DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CanA-14F and CanA1

DIOPT Version :9

Sequence 1:	NP_001245717.1	Gene:	CanA-14F / 8674098	FlyBaseID:	FBgn0267912	Length:	584	Species:	Drosophila melanogaster
Sequence 2:	NP_001247378.2	Gene:	CanA1 / 43670	FlyBaseID:	FBgn0010015	Length:	622	Species:	Drosophila melanogaster

Alignment Length:	574	Identity:	394/574 - (68%)
Similarity:	469/574 - (81%)	Gaps:	31/574 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 AATTGTAAGSGSGGAAGSAGTQQQGQGGTGTSSGPSSPT----KRSTISTKERVIDSVAFPPSRK 101
            :||:..::.:.....:.|:.:.:..:..:.:|..|::.:    |.....|:||::|.|..||:.|
  Fly     2 SATSTRSSVTRKSSLSKSSSSDKSAKSSSNSSKSPTAASGNKQKMQYTKTRERMVDDVPLPPTHK 66

  Fly   102 LTCADVF-DARTGKPQHDVLKQHFILEGRIEESAALRIIQEGATLLRTEKTMIDIEAPVTVCGDI 165
            ||.::|: |.:||||..|.|:|||:|||||||:.|||||.|||.|||.||.|||:|||:||||||
  Fly    67 LTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKNMIDVEAPITVCGDI 131

  Fly   166 HGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWSLKITYPQTLFLLRGNHECRHL 230
            ||||:||:||||:||.||||:|||||||||||||||||||||||||||||.||.|||||||||||
  Fly   132 HGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPTTLSLLRGNHECRHL 196

  Fly   231 TEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGLSPEIHELEDIRRLDRFKEP 295
            ||||||||||.|||||.:|||||:||||||||||:||||||:||||||||..|:||:.|:||:||
  Fly   197 TEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIFTLDDIKTLNRFREP 261

  Fly   296 PAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAACCDFLQNNNLLSIIRAHEAQDA 360
            ||:|||||||||||||||||||.::|::||||||||||:||:|||:|||.||||||:||||||||
  Fly   262 PAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKNNLLSIVRAHEAQDA 326

  Fly   361 GYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT 425
            |||||||:|.|||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Fly   327 GYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT 391

  Fly   426 WSLPFVGEKVTEMLVNVLNICSDDELMT---EESEEPL-----------SDDE------------ 464
            ||||||||||||||||:|||||||||:.   :|.||.|           |::.
  Fly   392 WSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANASNNNNNNNTPSKPASM 456

  Fly   465 AALRKEVIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSLKNAMQGFSP 529
            :|||||:|||||||||||:||||:|||||||||||||||||||||:||||||:.|||.|:||.:.
  Fly   457 SALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGALSGGRDSLKEALQGLTA 521

  Fly   530 NHKITSFAEAKGLDAVNERMPPRRDATPSPAEEGQKSLSAAAAAAANANANSIN 583
            :..|.|||||||||||||||||||....|.:.....:::.::::::|.|.|:.|
  Fly   522 SSHIHSFAEAKGLDAVNERMPPRRPLLMSASSSSITTVTRSSSSSSNNNNNNSN 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CanA-14F	NP_001245717.1	MPP_PP2B	115..419	CDD:277361	257/303 (85%)
CanA-14F	NP_001245717.1	PP2Ac	132..403	CDD:197547	229/270 (85%)
CanA1	NP_001247378.2	MPP_PP2B	81..385	CDD:277361	257/303 (85%)
CanA1	NP_001247378.2	PP2Ac	98..369	CDD:197547	229/270 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440203
Domainoid	1	1.000	296	1.000	Domainoid score	I796
eggNOG	1	0.900	-	-		E1_COG0639
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	787	1.000	Inparanoid score	I260
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm6407
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	P	PTHR45673
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X576
	11	10.800