Protein Alignment CG42594 and KCNQ2

DIOPT Version :9

• Sequence 1: NP_001162668.2
• Gene: CG42594 / 8674091
• FlyBaseID: FBgn0260971
• Length: 1039
• Species: Drosophila melanogaster
• Sequence 2: NP_001369164.1
• Gene: KCNQ2 / 3785
• HGNCID: 6296
• Length: 890
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 98/486 - (20%)
• Similarity: 150/486 - (30%)
• Gaps: 176/486 - (36%)

  Fly   554 SSSTGASGVPGSNNPATEAVLLHTHYHHHRAGGVGGVAVGGGPPHEWNFAKA---FLYSLTVLTT 615
            |:..||..:.||..|...::|     ...||||.|    .|.||....|.:.   |||
Human    34 STRDGALLIAGSEAPKRGSIL-----SKPRAGGAG----AGKPPKRNAFYRKLQNFLY------- 82

  Fly   616 IGYGNVAPRTTLGRIVTLAYAFFGIPLTLVY----------LSSTGS--ILARVAREVFS----- 663
                ||..|......:..||.|..:...||.          .||.|:  ||..|...||.
Human    83 ----NVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEKSSEGALYILEIVTIVVFGVEYFV 143

  Fly   664 ---KALCCCLCSNCGYCCYDEKRMAEKERRMRRKRQQEELRKQQAVMQEPYYVRDVFHATPEKDA 725
               .|.|||                    |.|..|.:.:..:      :|:.|.|:....
Human   144 RIWAAGCCC--------------------RYRGWRGRLKFAR------KPFCVIDIMVLI----- 177

  Fly   726 GAGAPPPNAGGPVGSVGGLGDIDSLSASES--------------RGSMHGLSILAPILLCFSMMI 776
                    |...|.:.|..|::.:.||..|              ||..  ..:|..::...|..:
Human   178 --------ASIAVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGT--WKLLGSVVYAHSKEL 232

  Fly   777 I---YIVFGAAVL-----YRLEKW------PILDGIYFCFMSLSTIGFGDMLPGLRRESNATTW- 826
            :   ||.|...:|     |..||.      ...|.:::..::|:|||:||..|        .||
Human   233 VTAWYIGFLCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYP--------QTWN 289

  Fly   827 ---FCSVYIMSGMTLTAMCFNV--------IHEEIVHRIRIVVEFKKTSAANSGGGLIGGGSVSG 880
               ..:.:.:.|::..|:...:        :.|:  ||.:   .|:|  ..|...|||
Human   290 GRLLAATFTLIGVSFFALPAGILGSGFALKVQEQ--HRQK---HFEK--RRNPAAGLI------- 340

  Fly   881 GAGGAGGSMMDVAHEEGGQYYVP--ASXHYEKRGHLYQRNPTEETLVTDTPTSLVLKDYVNHELV 943
                          :...::|..  :. ........|:|..|.....:.|.|      |....|:
Human   341 --------------QSAWRFYATNLSRTDLHSTWQYYERTVTVPMYSSQTQT------YGASRLI 385

  Fly   944 PILTM--------DPNGARLAPTPAPAYTPA 966
            |.|..        ..:|......|.|..:|:
Human   386 PPLNQLELLRNLKSKSGLAFRKDPPPEPSPS 416

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:285168	17/71 (24%)
		Ion_trans	<601..640	CDD:278921	10/41 (24%)
		Ion_trans_2	774..846	CDD:285168	19/97 (20%)
KCNQ2	NP_001369164.1	Ion_trans	92..324	CDD:395416	54/282 (19%)
		KCNQ_channel	448..669	CDD:397540
		KCNQ2_u3	684..774	CDD:406935
		KCNQC3-Ank-G_bd	786..886	CDD:403240

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D774951at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010