DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42594 and KCNK2

DIOPT Version :9

Sequence 1:NP_001162668.2 Gene:CG42594 / 8674091 FlyBaseID:FBgn0260971 Length:1039 Species:Drosophila melanogaster
Sequence 2:NP_001017425.2 Gene:KCNK2 / 3776 HGNCID:6277 Length:426 Species:Homo sapiens


Alignment Length:291 Identity:62/291 - (21%)
Similarity:102/291 - (35%) Gaps:116/291 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   600 WNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYLSSTGSILARVAREVFSK 664
            |:...:|.::.||:||||:||::|||..|:|..:.||..||||....|:..|..|.    .:|.|
Human   142 WDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLG----TIFGK 202

  Fly   665 ALCCCLCSNCGYCCYDEKRMAEKERRMRRKRQQEELRKQQAVMQEPYYVRDVFHATPEKDAGAGA 729
            .:.                                            .|.|.|            
Human   203 GIA--------------------------------------------KVEDTF------------ 211

  Fly   730 PPPNAGGPVGSVGGLGDIDSLSASESRGSMHGLSILAPILLCFSMMIIYIVFGAAVLYRLEKWPI 794
                              ...:.|:::     :.|::.|:......::::...|.:...:|.|..
Human   212 ------------------IKWNVSQTK-----IRIISTIIFILFGCVLFVALPAIIFKHIEGWSA 253

  Fly   795 LDGIYFCFMSLSTIGFGDMLPGLRRESN--------ATTWFCSVYIMSGMTLTAMCFNVIHE--- 848
            ||.|||..::|:||||||.:.|   .|:        ...||   :|:.|:...|...::|.:   
Human   254 LDAIYFVVITLTTIGFGDYVAG---GSDIEYLDFYKPVVWF---WILVGLAYFAAVLSMIGDWLR 312

  Fly   849 -------EIVHRIR---------IVVEFKKT 863
                   |.|...|         :..|||:|
Human   313 VISKKTKEEVGEFRAHAAEWTANVTAEFKET 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42594NP_001162668.2 Ion_trans_2 <599..656 CDD:285168 24/55 (44%)
Ion_trans <601..640 CDD:278921 16/38 (42%)
Ion_trans_2 774..846 CDD:285168 22/79 (28%)
KCNK2NP_001017425.2 Ion_trans_2 <142..196 CDD:400301 23/53 (43%)
Ion_trans_2 234..312 CDD:400301 23/83 (28%)
Required for basal channel activity. /evidence=ECO:0000250 354..426
Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250 378..426
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11003
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
33.010

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