DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42594 and KCNK1

DIOPT Version :9

Sequence 1:	NP_001162668.2	Gene:	CG42594 / 8674091	FlyBaseID:	FBgn0260971	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_002236.1	Gene:	KCNK1 / 3775	HGNCID:	6272	Length:	336	Species:	Homo sapiens

Alignment Length:	231	Identity:	53/231 - (22%)
Similarity:	83/231 - (35%)	Gaps:	88/231 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   589 GVAVGGGPPHEWN--FAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYLSSTG 651
            ||:|.......||  |..|..::.|||:|.|||:..|.:..|:...:.|:..|||.||::|:
Human    89 GVSVLSNASGNWNWDFTSALFFASTVLSTTGYGHTVPLSDGGKAFCIIYSVIGIPFTLLFLT--- 150

  Fly   652 SILARVAREVFSKALCCCLCSNCGYCCYDEKRMAEKERRMRRKRQQEELRKQQAVMQEPYYVRDV 716
            :::.|:...|..:.:..                                          :::|..
Human   151 AVVQRITVHVTRRPVLY------------------------------------------FHIRWG 173

  Fly   717 FHATPEKDAGAGAPPPNAGGPVGSVGGLGDIDSLSASESRGSMHGLSILAPILLCFSMMIIYIVF 781
            |                                        |...::|:..:||.|..:..:...
Human   174 F----------------------------------------SKQVVAIVHAVLLGFVTVSCFFFI 198

  Fly   782 GAAVLYRLE-KWPILDGIYFCFMSLSTIGFGDMLPG 816
            .|||...|| .|..|:..||||:||||||.||.:||
Human   199 PAAVFSVLEDDWNFLESFYFCFISLSTIGLGDYVPG 234

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:285168	20/58 (34%)
		Ion_trans	<601..640	CDD:278921	13/40 (33%)
		Ion_trans_2	774..846	CDD:285168	21/44 (48%)
KCNK1	NP_002236.1	Ion_trans_2	<101..157	CDD:400301	20/58 (34%)
		pore-forming domain	107..123		8/15 (53%)
		Ion_trans_2	192..267	CDD:400301	21/43 (49%)
		pore-forming domain	212..238		15/23 (65%)
		Important for intracellular retention in recycling endosomes. /evidence=ECO:0000269\|PubMed:19959478	293..299
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910