DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42594 and CG1688

DIOPT Version :9

Sequence 1:	NP_001162668.2	Gene:	CG42594 / 8674091	FlyBaseID:	FBgn0260971	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_610516.1	Gene:	CG1688 / 36005	FlyBaseID:	FBgn0027589	Length:	918	Species:	Drosophila melanogaster

Alignment Length:	1078	Identity:	160/1078 - (14%)
Similarity:	263/1078 - (24%)	Gaps:	631/1078 - (58%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 QQQHQQQQQQQQQRQRKRQGWCSCFSSTPGGGHAG-GGVGGGVAAGETG-KTPPGYGSKEKKKSR 315
            :|..:.:|.|..|..      ||....|......| |||||.....|.| ||.....:|.:...|
  Fly     5 EQAIKAKQPQPSQLD------CSIDDETDATEFGGLGGVGGAGCGSEMGAKTTASLTAKPRSSLR 63

  Fly   316 KATSQTVWSALLTNLGICMLLLAYTLLGSFIFLTIENEDSALLHQQHTLASTKRNLAGLGIGAAG 380
            :.....: ..|.:..|:.:|::.|::||..:|..:|
  Fly    64 RCCGHLL-KLLFSTPGLVLLVIGYSVLGGLLFPLLE----------------------------- 98

  Fly   381 IGSSIYQQQQQQQQQRTPHQQQQQHQAVQGRHADNDTMAAAAAAVAAQGTLAGSASAGGLNPFGQ 445
                                            |..|...:||.|.:
  Fly    99 --------------------------------APQDISKSAAIAKS------------------- 112

  Fly   446 PASSGEFVYGLDGMDATDLEAGGMPQFALSPDTYDVRQRTIENIWDITVSLNILYKENWTKLAAL 510
                                                |:..:..:|.||..||:||:.|||.|...
  Fly   113 ------------------------------------REDCLRELWIITEKLNVLYERNWTMLVHE 141

  Fly   511 EIAKFQDQLIKRLNEDVMLQLSHDDVANAPSSSSSSSSSSSSSSSSTGASGVPGSNNPATEAVLL 575
            ::.:|:..::                        :::...|:.||..|.:|:
  Fly   142 QLRRFEGSIV------------------------AATRQGSAGSSGGGGAGL------------- 169

  Fly   576 HTHYHHHRAGGVGGVAVGGGPPHEWNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGI 640
               :|...|..:|......|....|:|::|.|||:||:||||:|::.|||..|::.|:.||..|:
  Fly   170 ---FHEGSASALGHFGYDAGDSQSWSFSEALLYSVTVITTIGHGSLTPRTAAGKLATIFYALVGV 231

  Fly   641 PLTLVYLSSTGSILARVAREVFSKALCCCL----------------------------------- 670
            ||.|:.|||.|::||...:..:.: |||.|
  Fly   232 PLMLMCLSSLGALLADGLQCTYVR-LCCQLQRHQEHRRKSTPGTSTPSASSAANSREKDTDKRSK 295

  Fly   671 --CSNCGYCCYDEK--------------------------------------------------- 682
              .:||..|.||..
  Fly   296 RRMANCKGCQYDAANSETSLNDCLEYGQKGKLPPDKKEGDACQLLRNLNPQQHFYQQQQQQPQQP 360

  Fly   683 --------------RMAEKERRMRRKRQ-----------QEELRKQQAVMQE------------- 709
                          :.|.:::::::::|           |.:|::||..:|:
  Fly   361 DVMLMTTTSGSALLKYAPQQQQLQQQQQLSTATLPRQHHQMQLQQQQQQLQQNFVAVPSSMLRMP 425

  Fly   710 ----------------------------------------------------------------- 709

  Fly   426 LTVPPNCYAPATATIYFPFGHAPSAPGSPAHNQAHPTQNPNGNALGNTTLGSQPLVKYHTIHLQP 490

  Fly   710 ---------------------------------------PYYVRDVFHAT----------PEK-- 723
                                                   |.|.....||.          |::
  Fly   491 ASGKHRVLASGLQDATAVNLVTASEASTSTLEAITLPPPPAYQTASVHAVRRAKFVAKPLPQEIN 555

  Fly   724 ---DAGAGA----------PPPNAGGP----------------------VGSVGGLG-------- 745
               |.|.|:          |||::|.|                      .|..||.|
  Fly   556 ALMDCGTGSPDLSGRHDLLPPPHSGSPATGTAASPLLTYTAAATSPQLSAGIKGGSGPAPTAGAP 620

  Fly   746 --------------------------------------------------DIDSLSASESRGSM- 759
                                                              .:.:|.::.|.|::
  Fly   621 MLVSGAGRGAAALTDNGFMAAGVCGMGAAAAPLPVTSMGAATTTASSAASTLSALLSANSTGNVD 685

  Fly   760 -----------------HG-----------LSI-------------------------------- 764
                             ||           ||:
  Fly   686 IMEDEDEQERERLSNCPHGTPSRVPLIASPLSVPQDSGENTTRNTAFNRHTLQPLSRKTLLLTRR 750

  Fly   765 ---------------------------------------------------------------LA 766
                                                                           ..
  Fly   751 CHRHASGTLYDSTANNTETSDDEEYMQHGSEQFVLKKLRYHCDGKDCREAEDSEEEDEKADGRQV 815

  Fly   767 PILLCFSMMIIYIVFGAAVLYRLEKWPILDGIYFCFMSLSTIGFGDMLPGLRRESNA---TTWFC 828
            ||.|...::..||..|..:....|.|.::||.||||::|||||:||.:|.  |..|.   ..:.|
  Fly   816 PISLVLLILASYICVGTVIFALWENWSLVDGAYFCFVTLSTIGYGDFVPA--RSFNGPELQLYAC 878

  Fly   829 SVYIMSGMTLTAMCFNVIHEEIVHRI-RIVVEFKKTSA 865
            ..|::.|:.|.||.|:::..:::.:. ||.|..|...|
  Fly   879 CAYLLLGLVLVAMSFSILETQLMWKCKRIAVRLKLARA 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:285168	29/56 (52%)
		Ion_trans	<601..640	CDD:278921	19/38 (50%)
		Ion_trans_2	774..846	CDD:285168	28/74 (38%)
CG1688	NP_610516.1	Ion_trans_2	<191..247	CDD:285168	29/55 (53%)
CG1688	NP_610516.1	Ion_trans_2	822..896	CDD:285168	28/75 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461326
Domainoid	1	1.000	51	1.000	Domainoid score	I4317
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41373
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950