Protein Alignment CG42594 and KCNK18

DIOPT Version :10

• Sequence 1: NP_001162668.2
• Gene: CG42594 / 8674091
• FlyBaseID: FBgn0260971
• Length: 1039
• Species: Drosophila melanogaster
• Sequence 2: NP_862823.1
• Gene: KCNK18 / 338567
• HGNCID: 19439
• Length: 384
• Species: Homo sapiens
• Alignment Length: 295
• Identity: 72/295 - (24%)
• Similarity: 120/295 - (40%)
• Gaps: 57/295 - (19%)

  Fly   600 WNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYLSSTGSILARVAR----- 659
            |:|..:..:..||.:|:|||.:.|.|.||:.:.:.||.|||||..:.|:.||.|||.:..
Human   101 WSFLSSLFFCCTVFSTVGYGYIYPVTRLGKYLCMLYALFGIPLMFLVLTDTGDILATILSTSYNR 165

  Fly   660 ----EVFSKALCCCLCSNCGYCCYDEKRMAEK------------------------ERRMRRKRQ 696
                ..|::.|....|....:....:.:.|::                        ...|....:
Human   166 FRKFPFFTRPLLSKWCPKSLFKKKPDPKPADEAVPQIIISAEELPGPKLGTCPSRPSCSMELFER 230

  Fly   697 QEELRKQQAVMQEPYYVRDVFHATPEKDAGAGAPPPNAGGPVGSVGGLGDIDSLSASESRGSMHG 761
            ...|.||. .:|.|....:..::.||...|.           .|...:.::|.:.....|
Human   231 SHALEKQN-TLQLPPQAMERSNSCPELVLGR-----------LSYSIISNLDEVGQQVER----- 278

  Fly   762 LSILAPILLCFSMMIIYIVFGAAVLYRLE-KWPILDGIYFCFMSLSTIGFGDMLPGLRRESNATT 825
            |.|..||:..  ::..||...||:|...| :....:..||||::|:||||||.:    .|.....
Human   279 LDIPLPIIAL--IVFAYISCAAAILPFWETQLDFENAFYFCFVTLTTIGFGDTV----LEHPNFF 337

  Fly   826 WFCSVYIMSGMTLTAMCFNVIHEEIVHRIRIVVEF 860
            .|.|:||:.||.:..:.|.::...::...:.|:.|
Human   338 LFFSIYIIVGMEIVFIAFKLVQNRLIDIYKNVMLF 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:462301	24/55 (44%)
		Ion_trans_2	774..846	CDD:462301	25/72 (35%)
KCNK18	NP_862823.1	Ion_trans_2	94..155	CDD:462301	22/53 (42%)
		Selectivity filter 1. /evidence=ECO:0000305|PubMed:36426390	116..121		3/4 (75%)
		Interaction with calcineurin. /evidence=ECO:0000250|UniProtKB:Q6VV64	200..205		0/4 (0%)
		Interaction with YWHAH. /evidence=ECO:0000250|UniProtKB:Q6VV64	249..254		0/4 (0%)
		Ion_trans_2	285..364	CDD:462301	26/84 (31%)
		Selectivity filter 2. /evidence=ECO:0000305|PubMed:36426390	323..328		4/4 (100%)