DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42594 and twk-30

DIOPT Version :9

Sequence 1:	NP_001162668.2	Gene:	CG42594 / 8674091	FlyBaseID:	FBgn0260971	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_492381.3	Gene:	twk-30 / 185335	WormBaseID:	WBGene00006682	Length:	608	Species:	Caenorhabditis elegans

Alignment Length:	416	Identity:	88/416 - (21%)
Similarity:	149/416 - (35%)	Gaps:	141/416 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 LDGMDATDLEAGGMPQFALSPDTYDVRQRTIENIWDITVSLNILYKENWTKLAALEIAKFQDQLI 520
            |:|.....|:...|.:...:...|      ::.:|.:.......||.             .:.||
Worm    29 LEGEHLDALKKDHMAKIEQNAKDY------VDKLWSVAKRDRDKYKN-------------VEDLI 74

  Fly   521 KRLNEDVMLQLSHDDVANAPSSSSSSSSSSSSSSSSTGASGVPGSNNPATEAVLLHTHYHHHRAG 585
            |.:.||.:     ||..:                                   .:.|.::.||
Worm    75 KSVKEDTV-----DDFND-----------------------------------YVDTVFYAHR-- 97

  Fly   586 GVGGVAVGGGPPHE---WNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYL 647
                 ||..|...:   |:||.:..::.|:||:||||.|||.|..||:..:.|...|||||||.:
Worm    98 -----AVRHGYDEDSPTWDFANSVFFTTTMLTSIGYGYVAPSTFGGRLFGVIYCLIGIPLTLVTV 157

  Fly   648 SSTGSILAR----VAREVFSKALCCCLCSNCGYCCYDEKRMAEKERRMRRKRQQEELRKQQAVMQ 708
            ::....|:.    :..|:::|.|                       ..:|||:.|       |..
Worm   158 ANVAKFLSETIFFLHYELWNKCL-----------------------EWKRKRKGE-------VEA 192

  Fly   709 EPYYVRDVFHATPEKDAGAGAPPPNAGGPVGSVGGLGDIDSLSASESRGSMHGLSILAPILLCFS 773
            :|  ::.:|                           ||.::......|..:    :..|.|..|.
Worm   193 DP--LQPMF---------------------------GDDENEEEILDRVRL----VRFPPLTVFF 224

  Fly   774 MMIIYIVFGAAVLYRLEKWPILDGIYFCFMSLSTIGFGDMLPGLRRESNATTWFCSVYIMSGMTL 838
            .:.:|....|.|:...|.|..::.:||.|:|:.|:||||:.|     |....|....:::.|:.|
Worm   225 FVFVYGCIAAWVVRYWETWTYVESLYFIFISILTVGFGDIRP-----SPGNIWVTLAFVVVGVIL 284

  Fly   839 TAMCFNVIHEEIVHRIRIVVEFKKTS 864
            |.||.:|:....:..|..:....|:|
Worm   285 TTMCMDVVGRMYLKEIHYLGRKLKSS 310

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:285168	25/59 (42%)
		Ion_trans	<601..640	CDD:278921	16/38 (42%)
		Ion_trans_2	774..846	CDD:285168	22/71 (31%)
twk-30	NP_492381.3	Ion_trans_2	103..166	CDD:285168	25/62 (40%)
		Ion_trans_2	224..298	CDD:285168	23/78 (29%)
		FN3	379..469	CDD:238020
		FN3	475..565	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D542195at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920