Protein Alignment CG42594 and twk-44

DIOPT Version :10

• Sequence 1: NP_001162668.2
• Gene: CG42594 / 8674091
• FlyBaseID: FBgn0260971
• Length: 1039
• Species: Drosophila melanogaster
• Sequence 2: NP_509942.4
• Gene: twk-44 / 181349
• WormBaseID: WBGene00006694
• Length: 733
• Species: Caenorhabditis elegans
• Alignment Length: 735
• Identity: 151/735 - (20%)
• Similarity: 252/735 - (34%)
• Gaps: 252/735 - (34%)

  Fly   334 MLLLAYTLLGSFIFLTIE--NEDSALLHQQHTLASTKRNLAGLGIGAAGIGSSIYQQQQQQQQQR 396
            :||:||::||..||.:||  ||:..|..:::.:|:...:|.           .:..|
 Worm    74 ILLIAYSVLGGLIFWSIERPNEEIMLADKRNYIAALTDDLV-----------EVLMQ-------- 119

  Fly   397 TPHQQQQQHQAVQGRHADNDTMAAAAAAVAAQGTLAGSASAGGLNPFG-QPASSGEFVYGLDGMD 460
                       :..|..|.:       .|.:..|........|...|. .......:.|.|....
 Worm   120 -----------IHNRLIDFN-------RVYSNNTYLLMIHYRGYRKFALNQIHKSVYWYTLSTFY 166

  Fly   461 ATDLEAGGMPQFALSPDTYDVRQRTIENIWDITVSLNILYKENWTKLAALEIAKFQDQLIKRLNE 525
            .|:.|...:  .||.|       :..|.:|      ...::.|:.::.||:  .:.:||..|..|
 Worm   167 LTEHEMHKV--VALRP-------KNPEQLW------KRHFESNFGRIRALK--NYTEQLCLRCWE 214

  Fly   526 DVMLQLSHDDVANAPSSSSSSSSSSSSSSSSTGASGVPGSNNPAT----EAVLLHTHYHHHRAGG 586
                                              .||.|:|...|    ..::..:...::.:.|
 Worm   215 ----------------------------------LGVEGANQGWTRYNYSLMVNQSVEEYNNSVG 245

  Fly   587 VGGVAVGGGPPHEWNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYLSSTG 651
            :|.|..     ..|.|..|...::|..|||||||:..:|.||::..:.||..||||.|:.|..:|
 Worm   246 LGHVLT-----PVWTFWNAMFLAVTTYTTIGYGNITAKTKLGKLAAMVYAVVGIPLVLMILHKSG 305

  Fly   652 SILARVAREV--FSKALCCCLCSNCGYCCYDEKRMAEKERRMRRKRQQEELRKQQAVMQEPYYVR 714
            .:.......:  |...:....|...|            ::|:|
 Worm   306 RLFLMGLEHMWDFILRITDSFCVGSG------------KQRVR---------------------- 336

  Fly   715 DVFHATPEKDAGAGAPPPNAGGPVGSVGGLGDIDSLSASESRGSMHGLSILAPILLCFSMMIIYI 779
                              |.|                  |.|.|.      .|::|...:...::
 Worm   337 ------------------NTG------------------EDRISE------MPLILAIGVAFGWM 359

  Fly   780 VFGAAVLYRLEK-WPILDGIYFCFMSLSTIGFGDMLPGLRRESNATTWFCSV-YIMSGMTLTAMC 842
            ...||:..|.|| |......||.|.||:|||:||:.|     :|:...|... .|:.|::|.:||
 Worm   360 FLCAAIFLRFEKDWDYFKSFYFFFCSLTTIGYGDVTP-----TNSEDMFIIFGLIIIGLSLVSMC 419

  Fly   843 FNVIH---EEIVHRIRIVVEFKKTSAANSG----GGLIGG-----------GSVSGGAGGAGGSM 889
            .|||.   |::...:.:.: .::.:|...|    .|.||.           |.:..|...|.|:
 Worm   420 INVIQLKLEKLFEELLLTL-MEELNADPDGTRLKAGTIGAREMWRAWKKRRGKLKDGLERAKGA- 482

  Fly   890 MDVAHEEGGQY--YVPAS---------XHYEKRGH-----------------LYQRNPTEETLVT 926
            .|||::....:  .:|.|          .::|:.|                 .|......::.||
 Worm   483 RDVANKASENFVKMLPFSRKRERQNLIAEFQKKLHSKEKSTQTDFGYPRCEEAYTETSDVDSCVT 547

  Fly   927 DTPTSLVLKDYVNHELVPILTMDPNGARLAPT-----PAPAYTPA---NTSTGMPGSGEVT-TPG 982
            |..:| ::.|...|.|:.|    |:|....|:     |..|...|   ::|:..|.|...: .|.
 Worm   548 DFRSS-IISDKSQHHLLLI----PDGPICGPSRCESRPVVAMAEASLCSSSSVNPSSYPSSHRPS 607

  Fly   983 NSCIAHGSDPGLGYSSLSSP 1002
            :|.::  |.||   |.:|:|
 Worm   608 SSILS--SSPG---SRISAP 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:462301	23/56 (41%)
		Ion_trans_2	774..846	CDD:462301	25/73 (34%)
twk-44	NP_509942.4	Ion_trans_2	<254..308	CDD:462301	23/53 (43%)
		Ion_trans_2	354..>397	CDD:462301	17/47 (36%)