DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42594 and twk-44

DIOPT Version :9

Sequence 1:	NP_001162668.2	Gene:	CG42594 / 8674091	FlyBaseID:	FBgn0260971	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_509942.4	Gene:	twk-44 / 181349	WormBaseID:	WBGene00006694	Length:	733	Species:	Caenorhabditis elegans

Alignment Length:	735	Identity:	151/735 - (20%)
Similarity:	252/735 - (34%)	Gaps:	252/735 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   334 MLLLAYTLLGSFIFLTIE--NEDSALLHQQHTLASTKRNLAGLGIGAAGIGSSIYQQQQQQQQQR 396
            :||:||::||..||.:||  ||:..|..:::.:|:...:|.           .:..|
Worm    74 ILLIAYSVLGGLIFWSIERPNEEIMLADKRNYIAALTDDLV-----------EVLMQ-------- 119

  Fly   397 TPHQQQQQHQAVQGRHADNDTMAAAAAAVAAQGTLAGSASAGGLNPFG-QPASSGEFVYGLDGMD 460
                       :..|..|.:       .|.:..|........|...|. .......:.|.|....
Worm   120 -----------IHNRLIDFN-------RVYSNNTYLLMIHYRGYRKFALNQIHKSVYWYTLSTFY 166

  Fly   461 ATDLEAGGMPQFALSPDTYDVRQRTIENIWDITVSLNILYKENWTKLAALEIAKFQDQLIKRLNE 525
            .|:.|...:  .||.|       :..|.:|      ...::.|:.::.||:  .:.:||..|..|
Worm   167 LTEHEMHKV--VALRP-------KNPEQLW------KRHFESNFGRIRALK--NYTEQLCLRCWE 214

  Fly   526 DVMLQLSHDDVANAPSSSSSSSSSSSSSSSSTGASGVPGSNNPAT----EAVLLHTHYHHHRAGG 586
                                              .||.|:|...|    ..::..:...::.:.|
Worm   215 ----------------------------------LGVEGANQGWTRYNYSLMVNQSVEEYNNSVG 245

  Fly   587 VGGVAVGGGPPHEWNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYLSSTG 651
            :|.|..     ..|.|..|...::|..|||||||:..:|.||::..:.||..||||.|:.|..:|
Worm   246 LGHVLT-----PVWTFWNAMFLAVTTYTTIGYGNITAKTKLGKLAAMVYAVVGIPLVLMILHKSG 305

  Fly   652 SILARVAREV--FSKALCCCLCSNCGYCCYDEKRMAEKERRMRRKRQQEELRKQQAVMQEPYYVR 714
            .:.......:  |...:....|...|            ::|:|
Worm   306 RLFLMGLEHMWDFILRITDSFCVGSG------------KQRVR---------------------- 336

  Fly   715 DVFHATPEKDAGAGAPPPNAGGPVGSVGGLGDIDSLSASESRGSMHGLSILAPILLCFSMMIIYI 779
                              |.|                  |.|.|.      .|::|...:...::
Worm   337 ------------------NTG------------------EDRISE------MPLILAIGVAFGWM 359

  Fly   780 VFGAAVLYRLEK-WPILDGIYFCFMSLSTIGFGDMLPGLRRESNATTWFCSV-YIMSGMTLTAMC 842
            ...||:..|.|| |......||.|.||:|||:||:.|     :|:...|... .|:.|::|.:||
Worm   360 FLCAAIFLRFEKDWDYFKSFYFFFCSLTTIGYGDVTP-----TNSEDMFIIFGLIIIGLSLVSMC 419

  Fly   843 FNVIH---EEIVHRIRIVVEFKKTSAANSG----GGLIGG-----------GSVSGGAGGAGGSM 889
            .|||.   |::...:.:.: .::.:|...|    .|.||.           |.:..|...|.|:
Worm   420 INVIQLKLEKLFEELLLTL-MEELNADPDGTRLKAGTIGAREMWRAWKKRRGKLKDGLERAKGA- 482

  Fly   890 MDVAHEEGGQY--YVPAS---------XHYEKRGH-----------------LYQRNPTEETLVT 926
            .|||::....:  .:|.|         ..::|:.|                 .|......::.||
Worm   483 RDVANKASENFVKMLPFSRKRERQNLIAEFQKKLHSKEKSTQTDFGYPRCEEAYTETSDVDSCVT 547

  Fly   927 DTPTSLVLKDYVNHELVPILTMDPNGARLAPT-----PAPAYTPA---NTSTGMPGSGEVT-TPG 982
            |..:| ::.|...|.|:.|    |:|....|:     |..|...|   ::|:..|.|...: .|.
Worm   548 DFRSS-IISDKSQHHLLLI----PDGPICGPSRCESRPVVAMAEASLCSSSSVNPSSYPSSHRPS 607

  Fly   983 NSCIAHGSDPGLGYSSLSSP 1002
            :|.::  |.||   |.:|:|
Worm   608 SSILS--SSPG---SRISAP 622

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:285168	23/56 (41%)
		Ion_trans	<601..640	CDD:278921	15/38 (39%)
		Ion_trans_2	774..846	CDD:285168	25/73 (34%)
twk-44	NP_509942.4	Ion_trans_2	237..308	CDD:285168	26/75 (35%)
twk-44	NP_509942.4	Ion_trans_2	354..>397	CDD:285168	17/47 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910