DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42594 and twk-9

DIOPT Version :9

Sequence 1:	NP_001162668.2	Gene:	CG42594 / 8674091	FlyBaseID:	FBgn0260971	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_001294002.1	Gene:	twk-9 / 177803	WormBaseID:	WBGene00006664	Length:	568	Species:	Caenorhabditis elegans

Alignment Length:	461	Identity:	107/461 - (23%)
Similarity:	184/461 - (39%)	Gaps:	86/461 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   596 PPHEWNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYLSSTGSILARVARE 660
            |..:|:...:.:::.||:||||||:|||.|..||:..:.|...|:|.||:.::..|..|.|..:.
Worm   157 PAEKWSIGNSVIFAFTVITTIGYGHVAPETFEGRLFLIFYGVIGVPFTLLTIADLGMFLTRFLKN 221

  Fly   661 VFSKALCCCLCSNCGYCCYDEKRMAEKERRM--RRKRQQEELRKQQAVMQEPYYVRDVFHATPE- 722
            :.:.|                :|.|....::  :.|:|:.:.:|...||.:... .:|::...|
Worm   222 LLTMA----------------RRFAHYLVKLYQKAKKQRNKSQKTSPVMPDSER-SEVWNTGKEM 269

  Fly   723 KDAG-AGAPPPNAGGPVGSV-------GGLGDIDSLSASESRGSMHGLSILAPILLCFSMMIIYI 779
            |:.. ..|..|..|..:..:       |...|.:....:|.|.:...:: |.....|      |:
Worm   270 KEMSMRTAREPGEGDEIEVIENGNDENGKEEDEEEPENNEPRKTEESIA-LGITFTC------YL 327

  Fly   780 VFGAAVLYRLEKWPILD---GIYFCFMSLSTIGFGDMLPGLRRESNATTWFCSVYIMSGMTLTAM 841
            |.||.:|...|  |.:|   .:||.|::|:|||.||.:|    :|........:||..|:.||.|
Worm   328 VAGAKILSVYE--PEMDFFKALYFNFVTLTTIGLGDFVP----KSFDYLLITLIYIGIGLALTTM 386

  Fly   842 CFNVIHEEI--VHRIRIVVEFKKTSAANSGGGLIGGGSVSGGAGGAGGSMMDVAHEEGGQYYVPA 904
            ...:..:.:  :|.|...:|       |.|..::       ..||...:|..:....|.|:.:|.
Worm   387 AIEIAADLLKKLHYIGRKME-------NVGQAVV-------WFGGKKMTMKSLVKHLGDQFNIPE 437

  Fly   905 S--XHYE-----------KRGHL--YQRNPTEETLVTDTPTSLVLKDYVNHELVPILTMDPNGAR 954
            .   :::           ::|.:  .::.||...:..:...|  ..:..|.....:..:|.|  |
Worm   438 EELANFDMSAFVDNAIKVEKGEIATLRKPPTPPVVFRERAFS--FSNVRNSSESALKYVDDN--R 498

  Fly   955 LAPTPAPA-YTPANTSTGMPGSGEVTTPGNSCIAHGSDPGLGYSSLSSPLLDVMNTPTG--ANAS 1016
            .:.|..|. ||.....|    :..:.|..|...|...||.:....|....|..|:.||.  .|..
Worm   499 FSKTTQPTIYTVIIHET----TRTIDTLHNLADAIRRDPSIPRLDLDVHYLTDMSAPTSFDENYL 559

  Fly  1017 GVYTLA 1022
            ..||.|
Worm   560 RTYTNA 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:285168	22/56 (39%)
		Ion_trans	<601..640	CDD:278921	15/38 (39%)
		Ion_trans_2	774..846	CDD:285168	25/74 (34%)
twk-9	NP_001294002.1	Ion_trans_2	<159..217	CDD:285168	22/57 (39%)
twk-9	NP_001294002.1	Ion_trans_2	321..397	CDD:285168	26/87 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010