Protein Alignment CG42594 and twk-8

DIOPT Version :10

• Sequence 1: NP_001162668.2
• Gene: CG42594 / 8674091
• FlyBaseID: FBgn0260971
• Length: 1039
• Species: Drosophila melanogaster
• Sequence 2: NP_001023596.1
• Gene: twk-8 / 177727
• WormBaseID: WBGene00006663
• Length: 769
• Species: Caenorhabditis elegans
• Alignment Length: 500
• Identity: 117/500 - (23%)
• Similarity: 189/500 - (37%)
• Gaps: 118/500 - (23%)

  Fly   599 EWNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYLSSTGSILARVAREVFS 663
            :|.|..|..::.|:.||||||::|..|:.|||.|:.|:..|||..|:.|:..|..
 Worm   176 QWTFMSAMYFAGTLFTTIGYGDIACITSAGRIATVIYSCVGIPFMLITLNDLGKF---------- 230

  Fly   664 KALCCCLCSNCGYCC--YDEKRMAEKERRMRRKRQQEELRKQQAVMQEPYYVRDVFHATPEKDAG 726
                  |.:|...|.  :::........|:..:|.....:|...::              ..:||
 Worm   231 ------LYNNINGCVKGFEDFTTYLGAFRLCNRRGNGNFQKGDELV--------------TLEAG 275

  Fly   727 ----AGAPPPNA-GGPVGSVGGLGDIDSLSASESRGSMHGLSILAPILLCFSMMIIYIVFGAAVL 786
                ..||..:: ...:||.....|.:.:...|.| ||..:|    :.:...:.:.:|.|.:|:.
 Worm   276 TTGTTDAPEVSSLASELGSERNESDYEDIEDEEER-SMPRMS----VKVALGITVGWIFFCSALF 335

  Fly   787 YRLEKWPILDGIYFCFMSLSTIGFGDMLPGLRRESNATTWFCSVYIMSGMTLTAMCFNVIHEEI- 850
            ...|.|......||.|:||||||.||:  .::|.....  .|.|:::.|::|.:|..|||...:
 Worm   336 KLWEDWSYGQSCYFMFISLSTIGLGDV--SVQRRDMMV--LCFVFVIVGLSLVSMTINVIQVALE 396

  Fly   851 ---VHRI-RIVVEFKKTSAANSGGGLIGGGSVS----GGAGGAGGSMMDVAHEE----------- 896
               |:.| ::::::::..||   ||...|.||.    .|.......:|.:..:|
 Worm   397 DFYVNLIMKLILDYQEKMAA---GGDQMGASVGMMRMWGNNKTAKLLMPLLSKEKKKIAMEKVEV 458

  Fly   897 ---GGQYYVPA--SXHYEKRG-----HLYQRNPTEETLVTDTP---TSLVLKD------------ 936
               .....|||  : ..||.|     |:.:....||     .|   ..||.|.
 Worm   459 KAKNNGIEVPAILTDLDEKSGMPKLFHIEENTENEE-----PPKILEELVQKQIEIEEAAAENAV 518

  Fly   937 -YVNHEL---VPILTMDPNGARLAPTPAPAY------TPANTSTGMPGSGEVTTPGNSCIAHGSD 991
             :|.|:.   ..||..:..|.:   |....|      |.|..|.......:.....|| ||....
 Worm   519 LFVAHDANTQTDILQQEEKGHQ---TDEKQYGEEAVQTEAMQSDNQECETQTEVVHNS-IAETQT 579

  Fly   992 PGLGYSSLSSPLLDVMNTPTGANASGVYTLAEETELELQETQVDR 1036
            ..:.||.     .|.|..|...|.|.:.|...:|:.|..:|.:|:
 Worm   580 VIVDYSE-----ADTMTQPVIVNESDMQTDYVQTKEEELQTYIDK 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:462301	23/56 (41%)
		Ion_trans_2	774..846	CDD:462301	23/71 (32%)
twk-8	NP_001023596.1	Ion_trans_2	169..233	CDD:462301	24/72 (33%)
		Ion_trans_2	323..397	CDD:462301	25/77 (32%)