DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42594 and Kcnk2

DIOPT Version :9

Sequence 1:	NP_001162668.2	Gene:	CG42594 / 8674091	FlyBaseID:	FBgn0260971	Length:	1039	Species:	Drosophila melanogaster
Sequence 2:	NP_742039.1	Gene:	Kcnk2 / 170899	RGDID:	621448	Length:	426	Species:	Rattus norvegicus

Alignment Length:	291	Identity:	62/291 - (21%)
Similarity:	102/291 - (35%)	Gaps:	116/291 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   600 WNFAKAFLYSLTVLTTIGYGNVAPRTTLGRIVTLAYAFFGIPLTLVYLSSTGSILARVAREVFSK 664
            |:...:|.::.||:||||:||::|||..|:|..:.||..||||....|:..|..|.    .:|.|
  Rat   142 WDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLG----TIFGK 202

  Fly   665 ALCCCLCSNCGYCCYDEKRMAEKERRMRRKRQQEELRKQQAVMQEPYYVRDVFHATPEKDAGAGA 729
            .:.                                            .|.|.|
  Rat   203 GIA--------------------------------------------KVEDTF------------ 211

  Fly   730 PPPNAGGPVGSVGGLGDIDSLSASESRGSMHGLSILAPILLCFSMMIIYIVFGAAVLYRLEKWPI 794
                              ...:.|:::     :.|::.|:......::::...|.:...:|.|..
  Rat   212 ------------------IKWNVSQTK-----IRIISTIIFILFGCVLFVALPAVIFKHIEGWSA 253

  Fly   795 LDGIYFCFMSLSTIGFGDMLPGLRRESN--------ATTWFCSVYIMSGMTLTAMCFNVIHE--- 848
            ||.|||..::|:||||||.:.|   .|:        ...||   :|:.|:...|...::|.:
  Rat   254 LDAIYFVVITLTTIGFGDYVAG---GSDIEYLDFYKPVVWF---WILVGLAYFAAVLSMIGDWLR 312

  Fly   849 -------EIVHRIR---------IVVEFKKT 863
                   |.|...|         :..|||:|
  Rat   313 VISKKTKEEVGEFRAHAAEWTANVTAEFKET 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42594	NP_001162668.2	Ion_trans_2	<599..656	CDD:285168	24/55 (44%)
		Ion_trans	<601..640	CDD:278921	16/38 (42%)
		Ion_trans_2	774..846	CDD:285168	22/79 (28%)
Kcnk2	NP_742039.1	Ion_trans_2	<139..196	CDD:285168	23/53 (43%)
		Ion_trans_2	234..312	CDD:285168	23/83 (28%)
		Required for basal channel activity. /evidence=ECO:0000250\|UniProtKB:P97438	354..426
		Essential for chloroform and halothane sensitivity. /evidence=ECO:0000250\|UniProtKB:P97438	378..426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	66	1.000	Domainoid score	I9664
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11003
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010