DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FDY and HABP4

DIOPT Version :9

Sequence 1:	NP_001303579.2	Gene:	FDY / 8674077	FlyBaseID:	FBgn0265047	Length:	403	Species:	Drosophila melanogaster
Sequence 2:	NP_055097.2	Gene:	HABP4 / 22927	HGNCID:	17062	Length:	413	Species:	Homo sapiens

Alignment Length:	386	Identity:	110/386 - (28%)
Similarity:	163/386 - (42%)	Gaps:	87/386 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NRYELLFMDDDDSSGL-------EQPQI------AAVVAAPKKPEPAKAPKVP---------KSK 49
            ||:..|..|:.|...:       .|.|:      .|..||...|...::|...         :.:
Human    26 NRFHQLLDDESDPFDILREAERRRQQQLQRKRRDEAAAAAGAGPRGGRSPAGASGHRAGAGGRRE 90

  Fly    50 SEKENKPVVAGRKANTPVAKNA-SPVKGGKGPAGGDVGRPKNPTANGANN----QGRFNNNQRYG 109
            |:||.|.:.|      |||:.. ||  ||...|.|....|:.....|.|:    :|.....:|..
Human    91 SQKERKSLPA------PVAQRPDSP--GGGLQAPGQKRTPRRGEQQGWNDSRGPEGMLERAERRS 147

  Fly   110 NKE------------SIGEFGNELPQRQFNNRD----NRGPP------RVRSG---------EKF 143
            .:|            :..:|.:|.|..:| :||    .||.|      |.|.|         ::.
Human   148 YREYRPYETERQADFTAEKFPDEKPGDRF-DRDRPLRGRGGPRGGMRGRGRGGPGNRVFDAFDQR 211

  Fly   144 GKREFDRQSGSDKTGVKSIDKREGVGAHNWGSPK--QDIEDLKTTGETSPQAEKKDSANEQSADP 206
            |||||:|..|:||..|::.|...|.|...|||.|  .|:|......|.:...|.:.:..|:|  |
Human   212 GKREFERYGGNDKIAVRTEDNMGGCGVRTWGSGKDTSDVEPTAPMEEPTVVEESQGTPEEES--P 274

  Fly   207 A-----VAAEEDESKQMTLDEWKALRDQ-RAKPNYNLRKAGEGAADNAEWKKMIVL--SKKKESN 263
            |     ...||.:.::|||||||.|::| |.||.:|:||     .::....|.:|:  ||.::..
Human   275 AKVPELEVEEETQVQEMTLDEWKNLQEQTRPKPEFNIRK-----PESTVPSKAVVIHKSKYRDDM 334

  Fly   264 SEDELEYDPSLYPQRVGRLQRIVDIQFNFNDGRKG-GFRKGTRRGAGPCEGGFRNDGPRGE 323
            .:|:.|.|..::.:....:...::|.|. |..|.| |.|.|||.|.|..... .|.|||.|
Human   335 VKDDYEDDSHVFRKPANDITSQLEINFG-NLPRPGRGARGGTRGGRGRIRRA-ENYGPRAE 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FDY	NP_001303579.2	HABP4_PAI-RBP1	144..242	CDD:335891	42/105 (40%)
FDY	NP_001303579.2	PRK11634	<308..368	CDD:236941	6/16 (38%)
HABP4	NP_055097.2	IHABP4_N	16..131	CDD:292792	28/112 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	42..206		39/172 (23%)
		HABP4_PAI-RBP1	212..316	CDD:282609	42/110 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	227..320		33/99 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..413		16/36 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4546
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48663
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002116
OrthoInspector	1	1.000	-	-		mtm8547
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12299
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1570
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	8.070