Protein Alignment OtopLa and OTOP2

DIOPT Version :9

• Sequence 1: NP_001162676.1
• Gene: OtopLa / 8674066
• FlyBaseID: FBgn0259994
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_835454.1
• Gene: OTOP2 / 92736
• HGNCID: 19657
• Length: 562
• Species: Homo sapiens
• Alignment Length: 949
• Identity: 173/949 - (18%)
• Similarity: 273/949 - (28%)
• Gaps: 473/949 - (49%)

  Fly   111 QGTYETNPI--TGPIELWTSLFIVTSLVYAI-LLIVVCIAYVISDVTTHRLPVLYYET-FFTYLY 171
            ||..|:.|.  .||.|:|.....:.|::.|: :|::.|.  :||....:::.|  |:| .|..|.
Human     7 QGPKESPPAPRAGPREVWKKGGRLLSVLLAVNVLLLACT--LISGGAFNKVAV--YDTDVFALLT 67

  Fly   172 GVSILFLLYVFCFLLQESSCCNGGNGGSKPKPQPKEKKSKKAKNADPADSKDAKGSKDSGKAAKG 236
            .:.:|..|::..:||:...|         |...|
Human    68 AMMLLATLWILFYLLRTVRC---------PCAVP------------------------------- 92

  Fly   237 AAYQHTLAKFLEAPVDAEVAVTPKNVRKRKTTHSDLTHGSFFLRVGAIAFGLGAMIYIGLEFG-- 299
                                            :.|...|..:||.|.:.||:..:|....:.|
Human    93 --------------------------------YRDAHAGPIWLRGGLVLFGICTLIMDVFKTGYY 125

  Fly   300 -SFFEIPFDSPCHHILIGVNPLLQMIFTFMQMYFIFMNARLNIHRFKVIARFGLMHVVATNICVW 363
             ||||      |...:..::||:|.:|..:|.||::::|:..:|....:...|||..:.||:.:|
Human   126 SSFFE------CQSAIKILHPLIQAVFVIIQTYFLWVSAKDCVHVHLDLTWCGLMFTLTTNLAIW 184

  Fly   364 IRTLVKESLLEITIYHQKNEPEAGASSIAHSIRQHALRHAGTVLRTHAGPNSEFEVLDGEDILPK 428
            :..:|.||:      ||.:     :.|.:||...||
Human   185 MAAVVDESV------HQSH-----SYSSSHSNASHA----------------------------- 209

  Fly   429 DVYKSDNVLSKLVRNTVDGISKSLGMGGDQALDSSTTSSSTTTTTRAPFTTPNYQWHSTTMARKL 493
                      :|:              .||..|
Human   210 ----------RLI--------------SDQHAD-------------------------------- 218

  Fly   494 KKFITSATTAATTAAGSSSTASSTTTISPTISSTTIPSTTISSTTISSSTTFSPFSPSTTTTTTT 558
                                                                             
Human   219 ----------------------------------------------------------------- 218

  Fly   559 TAAALNLETSGSESPFGGLQRILSSAAPPSLAPVDGFGSASAATPTSGSGAGSFVDSFLASTLSP 623
                         :|.||                                     ||.|.||
Human   219 -------------NPVGG-------------------------------------DSCLCST--- 230

  Fly   624 ASSTEGSASIMNNLFGQGPMENSFQTYTDLGHEEATGLVSFENLESLDNIYPAALSSNIGTLNST 688
                     .:..:|.||..
Human   231 ---------AVCQIFQQGYF--------------------------------------------- 241

  Fly   689 ACGRIDIMGTIVYDSAPYLYPFIIEYSLIGAVVLYVMWKHIGRY----PGRMNDEDLEHRLEVML 749
                             |||||.|||||..:.:||||||::||:    ||..:..     ..|.|
Human   242 -----------------YLYPFNIEYSLFASTMLYVMWKNVGRFLASTPGHSHTP-----TPVSL 284

  Fly   750 SRRAVAMAQQARSGRVDCVGSSKGLFFGLLLLVGALICLILFFVLV-----RHQQFSLLAIYLAD 809
            .|...                ..|...||||.|..|...|::.|.|     |.:|  .|.||.
Human   285 FRETF----------------FAGPVLGLLLFVVGLAVFIIYEVQVSGDGSRTRQ--ALVIYY-- 329

  Fly   810 ASHCILMAFAILAIIVGFIRVKNLKFRCEEQSN----LNDILLRISAFGLFTYSVFSIIAGSLKV 870
            :.:.:.:....|..:.|.|..:..:...:...|    |:..||..:|.|.:..|.:||:|    |
Human   330 SFNIVCLGLTTLVSLSGSIIYRFDRRAMDHHKNPTRTLDVALLMGAALGQYAISYYSIVA----V 390

  Fly   871 LESEPSLLVT----TTGGVAVFQVILQLLFIAD-------------------------------- 899
            :...|..|:.    |...:.:.|...|.:||.:
Human   391 VAGTPQDLLAGLNLTHALLMIAQHTFQNMFIIESLHRGPPGAEPHSTHPKEPCQDLTFTNLDALH 455

  Fly   900 -----------VS------RRRVHLPEHDRSKPGRQ----IVTFLLICNVAMFAIYTFEAQKVFA 943
                       ||      |..|.:....||:..||    |..|||:|||.::.:..|.|:..|:
Human   456 TLSACPPNPGLVSPSPSDQREAVAIVSTPRSQWRRQCLKDISLFLLLCNVILWIMPAFGARPHFS 520

  Fly   944 NPVQLEFYGFVPWSIIQRITLPLCIFHRFHSAVTLAEIW 982
            |.|:::|||:..|::|..|.||..||:|.|:..:|.|::
Human   521 NTVEVDFYGYSLWAVIVNICLPFGIFYRMHAVSSLLEVY 559

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>405	CDD:281218	37/129 (29%)
		Otopetrin	<679..972	CDD:281218	89/362 (25%)
OTOP2	NP_835454.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		4/12 (33%)
		Otopetrin	103..548	CDD:367383	141/764 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	137	1.000	Inparanoid score	I4547
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8528
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	8.050