DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OtopLa and Otop3

DIOPT Version :9

Sequence 1:	NP_001162676.1	Gene:	OtopLa / 8674066	FlyBaseID:	FBgn0259994	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_081408.2	Gene:	Otop3 / 69602	MGIID:	1916852	Length:	596	Species:	Mus musculus

Alignment Length:	375	Identity:	99/375 - (26%)
Similarity:	149/375 - (39%)	Gaps:	112/375 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   675 PAALSSNIGT-----LNSTACGRIDIMGTIVYDSAPYLYPFIIEYSLIGAVVLYVMWK------- 727
            |..||.| ||     ||:|.| .:...|.::      ||||..||.||...||:||||
Mouse   264 PYLLSGN-GTNTCMCLNTTVC-EVFRKGYLM------LYPFSTEYCLICCAVLFVMWKNVSRSLA 320

  Fly   728 -HIGRYPGRMNDEDLEHRLEVMLSRRAVAMAQQARSGRVDCVGSSKGLFFGLLLLVGALICLILF 791
             |.|.:|.|.     ..||.                      |:..|...|||.|| |.:|:.:.
Mouse   321 AHTGAHPNRS-----PFRLH----------------------GTIFGPLLGLLALV-AGVCVFVL 357

  Fly   792 FVL------VRHQQFSL-LAIYLADASHCIL--MAFAILA-IIVGFIRVKNLKFRCEEQSNLNDI 846
            |.:      :..|.|:| .|.|:|     :|  |:.|.|| ..:..:..:.|........:|:.:
Mouse   358 FQIEASGPDIARQYFTLYYAFYVA-----VLPTMSLACLAGTAIHGLEERELDTLKNPTRSLDVV 417

  Fly   847 LLRISAFGLFTYSVFSIIAGSLKVLESEP----SLLVTTTGGVAVFQVILQLLFIADVSRRR--- 904
            ||..:|.|....:.|||:|    ::.::|    :.|:.....:.:.|.|.|.|||.:...||
Mouse   418 LLMGAALGQMGIAYFSIVA----IVATQPHELLNQLILAYSLLLILQHITQNLFIIEGLHRRPLW 478

  Fly   905 ------------VHLPE--------HDRSKPGR-----------------QIVTFLLICNVAMFA 932
                        |.||.        .|..:..|                 :|..||::||:.::.
Mouse   479 EPAVSGVMEKQDVELPRRGSLRELGQDLRRASRAYIHSFSHLNWKRRMLKEISLFLILCNITLWM 543

  Fly   933 IYTFEAQKVFANPVQLEFYGFVPWSIIQRITLPLCIFHRFHSAVTLAEIW 982
            :..|.....|.|.::.:|||:..|..|....|||.:|:|.||...|.|::
Mouse   544 MPAFGIHPEFENGLEKDFYGYRTWFTIVNFGLPLGVFYRMHSVGGLVEVY 593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>405	CDD:281218
OtopLa	NP_001162676.1	Otopetrin	<679..972	CDD:281218	92/359 (26%)
Otop3	NP_081408.2	Otopetrin	143..582	CDD:281218	94/362 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4117
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8758
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.930