DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OtopLa and otop2

DIOPT Version :9

Sequence 1:	NP_001162676.1	Gene:	OtopLa / 8674066	FlyBaseID:	FBgn0259994	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_001338079.4	Gene:	otop2 / 494472	ZFINID:	ZDB-GENE-050104-2	Length:	572	Species:	Danio rerio

Alignment Length:	374	Identity:	95/374 - (25%)
Similarity:	150/374 - (40%)	Gaps:	86/374 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   668 ESL-DNIYPAALSSNIGTLNSTACGR------------IDIMGTIVYDSAPYLYPFIIEYSLIGA 719
            ||| ..:.|....:|..:.|.|..||            .|:.....|    |||||.|||||..:
Zfish   221 ESLHQTVAPVKPPTNNNSYNDTLDGRAAASECECLHNMCDLFEKAYY----YLYPFNIEYSLFAS 281

  Fly   720 VVLYVMWKHIGRYPGRMNDEDLEHRLEVMLSRRAVAMAQQARSGRVDCVGSSKGLFFGLLLLVGA 784
            .:.|||||::||   :|:|.. .|:|...|....|                  |...||::||..
Zfish   282 AMTYVMWKNVGR---KMDDHH-SHKLHFSLWDVLV------------------GPLAGLIVLVAG 324

  Fly   785 LICLILFFVLV-----RHQQFSLLAIYLADASHCILMAFAILAIIVGFIRVKNLKFRCEEQSNLN 844
            |...:::.|.|     :.::.:|:..|:.:....:||:.:.||..:.|...|..:...:..:...
Zfish   325 LATFVVYEVDVSKDDPKKKEEALIMHYIMNIVAVLLMSSSALAGCILFRMDKREQVSGKNPTRSL 389

  Fly   845 DILLRISA-FGLFTYSVFSIIAGSLKVLESEPSLLVTTTGGVAVFQVILQLLFI----------- 897
            |:.|.:.| .|.|....|:|:|.....::...:.|......:.|.::.:|..|:
Zfish   390 DVGLLVGASLGQFLICYFTIVAVLASGVQGHTNGLNLACAMLTVIELCIQNAFLIKGLHREPFKE 454

  Fly   898 ---------------ADVSRRRVHL-PEHDRSKP-----GR---------QIVTFLLICNVAMFA 932
                           .|..||...: |.|....|     ||         :|..|||:|||.::.
Zfish   455 TEVATVFANVMAVKERDPERRSSSIVPAHTLPIPLTLLQGRMSWKRRVLKEICAFLLLCNVTLWI 519

  Fly   933 IYTFEAQKVFANPVQLEFYGFVPWSIIQRITLPLCIFHRFHSAVTLAEI 981
            |..|.|:..|.|.|..:.|.|..|:.:..|.:|..||:|.||..:|.|:
Zfish   520 IPAFGARPQFDNTVGPDVYEFQTWAAVVNIGMPFGIFYRMHSVASLFEV 568

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>405	CDD:281218
OtopLa	NP_001162676.1	Otopetrin	<679..972	CDD:281218	86/351 (25%)
otop2	XP_001338079.4	Otopetrin	133..558	CDD:281218	90/362 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4607
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6364
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.190