Protein Alignment OtopLa and OtopLb

DIOPT Version :10

• Sequence 1: NP_001162676.1
• Gene: OtopLa / 8674066
• FlyBaseID: FBgn0259994
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_608758.1
• Gene: OtopLb / 33539
• FlyBaseID: FBgn0031514
• Length: 797
• Species: Drosophila melanogaster
• Alignment Length: 883
• Identity: 214/883 - (24%)
• Similarity: 326/883 - (36%)
• Gaps: 326/883 - (36%)

  Fly   115 ETNPITGPIELWTSLFIVTSLVYAILLIVVCIAYVISDVTTHRLPVLYYETFFTYLYGVSILFLL 179
            :.|..||...:.::|    |..|..||:::.:...|::|.:.::|...|:.|:.|||..||||::
  Fly   231 DKNRRTGNDAISSAL----SATYCKLLVLLGVCLPITEVISDQIPTYVYQGFYVYLYVGSILFVI 291

  Fly   180 YVFCFLLQESSCCNGGNGGSKPKPQPKEKKSKKAKNADPADSKDAKGSKDSGKAAKGAAYQHTLA 244
            :::....:..|..|.             .|....||:
  Fly   292 FLYISAFRNRSLFNA-------------LKDYHEKNS---------------------------- 315

  Fly   245 KFLEAPVDAEVAVTPKNVR-KRKTTHSDLTHGSFFLRVGAIAFGLGAMIYIGLEFGSFFEIPFDS 308
                            ||. |.|.||    .|||:||||||||.:|.|:|.|||||.|||:....
  Fly   316 ----------------NVHLKHKVTH----FGSFYLRVGAIAFAIGTMVYSGLEFGQFFELNGHP 360

  Fly   309 PCHHILIGVNPLLQMIFTFMQMYFIFMNAR-LNIHRFKVIARFGLMHVVATNICVWIRTLVKESL 372
            .|..:.:.:.|:.:|:....|:.|||:|.. :::.|.||.:||||||:||||:|.|:..||:|:.
  Fly   361 GCRDVFVAITPICRMVLCIAQVQFIFLNTTYMDMARHKVTSRFGLMHMVATNLCEWLYVLVEETK 425

  Fly   373 LEITIYHQKNEPEAGASSIAHSIRQHALRHAGTVLRTHAGPNSEFEVLDGEDILPKDVYKSDNVL 437
            .|  |:|               |.||.:
  Fly   426 HE--IFH---------------ISQHEV------------------------------------- 436

  Fly   438 SKLVRNTVDGISKSLGMGGDQALDSSTTSSSTTTTTRAPFTTPNYQWHSTTMARKLKKFITSATT 502
                               |.|.|....:||.:.|..|......:|.|.
  Fly   437 -------------------DPAHDLVIHNSSMSRTDWAAVNESLHQHHH---------------- 466

  Fly   503 AATTAAGSSSTASSTTTISPTISSTTIPSTTISSTTISSSTTFSPFSPSTTTTTTTTAAALNLET 567
                              ...:::|.:  ..:||..::.:.|.||
  Fly   467 ------------------HHALNNTLV--ANVSSVIVNMTITPSP-------------------- 491

  Fly   568 SGSESPFGGLQRILSSAAPPSLAPVDGFGSASAATPTSGSGAGSFVDSFLASTLSPASSTEGSAS 632
                                              ||.:.||
  Fly   492 ----------------------------------TPAAFSG------------------------ 498

  Fly   633 IMNNLFGQGPMENSFQTYTDLGHEEATGLVSFENLESLDNIYPAALSSNIGTLNSTACGRIDIMG 697
                                                                     |.|..|||
  Fly   499 ---------------------------------------------------------CSRTTIMG 506

  Fly   698 TIVYDSAPYLYPFIIEYSLIGAVVLYVMWKHIGRYPGRMNDEDLEHRLEVMLSRRAVAMAQQARS 762
            .:|...:|:|:|..||||||.||:|:.|||.:...|    |.|...:..|     ..|.|:.|..
  Fly   507 ALVQQLSPFLFPCTIEYSLICAVILFEMWKTVKSIP----DIDKTRKNSV-----KPAAAKPAHH 562

  Fly   763 GRVDCVGSSKGLFFGLLLLVGALICLILFFVLVRHQQFSLLAIYLADASHCILMAFAILAIIVGF 827
            ..|||..|.||||||:|::|..:|.:|::|||.....:.|:|..........:......|:|.|.
  Fly   563 FSVDCSQSHKGLFFGILIIVMTIISMIMYFVLYTQPGYELVATQEVTLWETFMYFMCAAAVITGM 627

  Fly   828 IRVKNLKF----RCEEQS-NLNDILLRISAFGLFTYSVFSIIAGSLKVLESEPSLLVTTTGGV-A 886
            |.:::|::    ..|..| :|:::||.::..|::.|.:|||:.......::.|..:......| .
  Fly   628 ILMRDLRYIKNTSDEHHSMDLDNLLLIVAQTGVYLYGMFSILGSYFAKWDTVPDRVEGIIAEVFG 692

  Fly   887 VFQVILQLLFIADVSRRRVHLPEHDRSKPGRQIVTFLLICNVAMFAIYTFEAQKVFANPVQLEFY 951
            |.|..||.:||...|.||.......|.||||:|:||||:.|:|::.:.|....:.......|||:
  Fly   693 VVQTSLQTMFILHSSHRRCRGTNQVRRKPGREIITFLLVANIAIWFVNTLIKGRAVFRESHLEFF 757

  Fly   952 GFVPWSIIQRITLPLCIFHRFHSAVTLAEIWKTTYKAR 989
            |...|:||..|::||.||:||||.:.|.|:||.||||:
  Fly   758 GVWGWTIITHISMPLAIFYRFHSTICLFEVWKITYKAK 795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>425	CDD:460840	51/147 (35%)
		Otopetrin	<673..972	CDD:460840	98/304 (32%)
OtopLb	NP_608758.1	Otopetrin	330..778	CDD:460840	168/700 (24%)