DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment OtopLa and otop1

DIOPT Version :9

Sequence 1:	NP_001162676.1	Gene:	OtopLa / 8674066	FlyBaseID:	FBgn0259994	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	NP_942098.1	Gene:	otop1 / 322893	ZFINID:	ZDB-GENE-030131-1613	Length:	586	Species:	Danio rerio

Alignment Length:	405	Identity:	91/405 - (22%)
Similarity:	152/405 - (37%)	Gaps:	133/405 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   662 VSFENLESLDNIYPAALSSNIGTLNSTACGRIDIMGTIVYDSAPYLYPFIIEYSLIGAVVLYVMW 726
            :.:.||.::|.......::::..:.||              |..|||||.|||.:..:.:|:|||
Zfish   230 MGYANLSTVDVQPHCNCTTSVWLMFST--------------SLYYLYPFNIEYHIFVSAMLFVMW 280

  Fly   727 KHIGRYPGRMNDEDLEHRLEVMLSRRAVAMAQQARSGRVDCVGSSKGLFFGLLLLVGALICLILF 791
            |:|||...|.::.          .||:.               .|.||..|.|   |.|:.|.
Zfish   281 KNIGRTLDRHSNR----------KRRST---------------GSTGLLLGPL---GGLVALA-- 315

  Fly   792 FVLVRHQQFSLLAIYL-----------ADASHCILMAFAILAIIVGFIRVKNLKFRCEEQ----- 840
                  ...|:|.:||           |..|.......|::|.:........|.:|.|.:
Zfish   316 ------SSVSVLVVYLIHLEKTEEMHEAAVSMFYYYGVAMMACMCVGSGTGLLVYRMENRPMDTG 374

  Fly   841 SN----LNDILLRISAFGLFTYSVFSIIAGSLKVLESEPSLLVT--TTGGVAVFQVILQLLFIAD 899
            ||    |:..||..|:.|.:..|..|::|...:..:..||...|  |...:.|.:..:|.|||.:
Zfish   375 SNPARTLDTELLLASSLGSWLMSWCSVVASVAEAGQKSPSFSWTSLTYSLLLVLEKCIQNLFIVE 439

  Fly   900 VSRRR---------------VHLP-----------EHDRSK------------------------ 914
            ...||               |.:|           .||:.:
Zfish   440 SLYRRHSEEEEDAAAPQVFSVAVPPYDGILNHGYEAHDKHREAEPAAGSHALSRKQPDAPLPAGQ 504

  Fly   915 -----PGRQ------IVTFLLICNVAMFAIYTFEAQKVFANPVQLEFYGFVPWSIIQRITLPLCI 968
                 |||:      |..||.:||::::.:..|..:..:.||::.|.:|...|:.:..:.:||.:
Zfish   505 RLDVTPGRKRQILKNICMFLFMCNISLWILPAFGCRPQYDNPLENETFGTSVWTTVLNVAIPLNL 569

  Fly   969 FHRFHSAVTLAEIWK 983
            |:|.||..:|.|:::
Zfish   570 FYRMHSVASLFEVFR 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>405	CDD:281218
OtopLa	NP_001162676.1	Otopetrin	<679..972	CDD:281218	83/375 (22%)
otop1	NP_942098.1	Otopetrin	127..572	CDD:281218	86/391 (22%)
		FYR-box	163..167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	484..505		0/20 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	131	1.000	Inparanoid score	I4607
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6364
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.100