Protein Alignment OtopLa and otpl-3

DIOPT Version :10

• Sequence 1: NP_001162676.1
• Gene: OtopLa / 8674066
• FlyBaseID: FBgn0259994
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_509170.1
• Gene: otpl-3 / 259710
• WormBaseID: WBGene00017449
• Length: 566
• Species: Caenorhabditis elegans
• Alignment Length: 904
• Identity: 152/904 - (16%)
• Similarity: 269/904 - (29%)
• Gaps: 433/904 - (47%)

  Fly   124 ELWTSLFI--VTSLVYAILLIVVCIAYVISDV-----TTHRLPVLYYETFFTYLYGVSILFLLYV 181
            :.|:..::  :.:..|||.:::..|...:|::     .|.::.:... ...|:|.|.||||:.|.
 Worm    41 DAWSRAYVFRLFTCFYAIFIVIAGIVIELSNIIAAEENTGKISIKDL-VLGTWLLGGSILFIAYC 104

  Fly   182 --------FCFLLQESSCCNGGNGGSKPKPQPKEKKSKKAKNADPADSKDAKGSKDSGKAAKGAA 238
                    |....|..|..|.|...::|
 Worm   105 SYLVHDMHFTIKRQRISLRNSGISATEP------------------------------------- 132

  Fly   239 YQHTLAKFLEAPVDAEVAVTPKNVRKRKTTHSDLTHGSFFLRVGAIAFGLGAMIYIGLEFGSFFE 303
                           ||.             ::.:.||.:||:|.:.||:..::|..|    .|.
 Worm   133 ---------------EVL-------------ANTSTGSLYLRLGCVVFGIIGVVYYLL----IFV 165

  Fly   304 IPF------DSPCHHILIGVNPLLQMIFTFMQMYFIFMNARLNIHRFKVIARFGLMHVVATNICV 362
            |..      :..| .::..|..::..:|.|:||:|::.|.::.......:|||||||:..||:.:
 Worm   166 ICLLGWSSNEGEC-SVISDVLNVMAAVFIFVQMWFVYCNGKIIFTGDGNLARFGLMHLTGTNLWM 229

  Fly   363 WIRTLVKESLLEI-TIYHQKNEPEAGASSIAHSIRQHALRHAGTVLRTHAGPNSEFEVLDGEDIL 426
            |:|.::.|.:..: .|.|.::...:.||:..|.:.:.|.:
 Worm   230 WLRYILYEEVETVKEIRHVQHANLSKASAHHHEVHEEACK------------------------- 269

  Fly   427 PKDVYKSDNVLSKLVRNTVDGISKSLGMGGDQALDSSTTSSSTTTTTRAPFTTPNYQWHSTTMAR 491
                                                                             
 Worm   270 ----------------------------------------------------------------- 269

  Fly   492 KLKKFITSATTAATTAAGSSSTASSTTTISPTISSTTIPSTTISSTTISSSTTFSPFSPSTTTTT 556
                                                                             
 Worm   270 ----------------------------------------------------------------- 269

  Fly   557 TTTAAALNLETSGSESPFGGLQRILSSAAPPSLAPVDGFGSASAATPTSGSGAGSFVDSFLASTL 621
                                                                             
 Worm   270 ----------------------------------------------------------------- 269

  Fly   622 SPASSTEGSASIMNNLFGQGPMENSFQTYTDLGHEEATGLVSFENLESLDNIYPAALSSNIGTLN 686
                   |...|.|                  |:.|
 Worm   270 -------GVLCIFN------------------GYNE----------------------------- 280

  Fly   687 STACGRIDIMGTIVYDSAPYLYPFIIEYSLIGAVVLYVMWKHIGRYPGRMNDEDLEHRLEVMLSR 751
                               ::|..::|||||.|.|.:|.|.::    .|:..|.:|.:::    :
 Worm   281 -------------------FMYTCVVEYSLICAGVAFVFWANL----ERLKREQMEKKMK----K 318

  Fly   752 RAVAMAQQARSGRVDCVGSSKGLFFGLLLLVGALICLILFFVLVRHQQFSLLAIYLADAS----- 811
            |::.        ::||..:::|||.|...::..:|.:.||            ..|.:|.:
 Worm   319 RSIL--------KIDCSRTAEGLFAGFACIIVTIIAIALF------------NAYSSDKNVAQWI 363

  Fly   812 -HCILMAFAILA---IIVGFIRVKNLKFRCEEQSNLND-------ILLRISAFGLFTYSVFSIIA 865
             .|..|:|.:::   ::..|.|::.|||..|:....:|       |||.:...|...:|:..|::
 Worm   364 FSCTNMSFFLVSTFLVVFAFWRMRYLKFLMEDDDEEDDNAELLDRILLVVGLIGELIFSIGGILS 428

  Fly   866 GSLKVLESEPSLLVTTTGGVAVFQVILQLLFIADVSRRRVHLPEHD--RSKPGRQIVTFLLICNV 928
            ....:....| |::.||..:.:.||..|...:...||.|:......  |.|||:|::|.||:.|.
 Worm   429 FINNMTIGLP-LIIFTTNVLRLIQVTFQSCLLMVASRLRIEESNQHMLRYKPGKQVITMLLMMNC 492

  Fly   929 AMFAIYTFEAQKVFANPVQLEFYGFVPWSIIQRITLPLCIFHRFHSAVTLAEIWKTTYK 987
            |.|.:..|||||...|...:..||...|:|:.|...||.||:||||:...|||||.|::
 Worm   493 AQFMMNVFEAQKAGINDEMIHMYGSYYWAIVVRGCSPLTIFYRFHSSACFAEIWKKTFR 551

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>425	CDD:460840	35/153 (23%)
		Otopetrin	<673..972	CDD:460840	77/316 (24%)
otpl-3	NP_509170.1	Otopetrin	144..536	CDD:460840	117/718 (16%)