Protein Alignment OtopLa and Otop2

DIOPT Version :9

• Sequence 1: NP_001162676.1
• Gene: OtopLa / 8674066
• FlyBaseID: FBgn0259994
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_001349329.1
• Gene: Otop2 / 237987
• MGIID: 2388365
• Length: 563
• Species: Mus musculus
• Alignment Length: 964
• Identity: 174/964 - (18%)
• Similarity: 276/964 - (28%)
• Gaps: 487/964 - (50%)

  Fly    96 PNPNKYSFMPAKITVQGTYETNPITGPIELWTSLFIVTSLVYAI-LLIVVCIAYVISDVTTHRLP 159
            |:||:  .:|           .|...|.|:|.....:.|::.|: :|::.|.  :||....:::.
Mouse     7 PHPNE--SLP-----------GPRASPREVWKKGGRLLSVLLAVNVLLLACT--LISGGAFNKVA 56

  Fly   160 VLYYET-FFTYLYGVSILFLLYVFCFLLQESSCCNGGNGGSKPKPQPKEKKSKKAKNADPADSKD 223
            |  |:| .|..|..:.:|..|::..:||:.:.|                        .|....:|
Mouse    57 V--YDTDVFALLTTMMLLAALWIVFYLLRTARC------------------------PDAVPYRD 95

  Fly   224 AKGSKDSGKAAKGAAYQHTLAKFLEAPVDAEVAVTPKNVRKRKTTHSDLTHGSFFLRVGAIAFGL 288
            |                                            |:    |..:||.|.:.||:
Mouse    96 A--------------------------------------------HA----GPIWLRGGLVLFGI 112

  Fly   289 GAMIYIGLEFG---SFFEIPFDSPCHHILIGVNPLLQMIFTFMQMYFIFMNARLNIHRFKVIARF 350
            ..::....:.|   ||||      |...:..::|::|.:|..:|.||::::|:..||....:.|.
Mouse   113 CTLVMDVFKTGYYSSFFE------CQSAIKILHPIIQAVFVIVQTYFLWISAKDCIHTHLDLTRC 171

  Fly   351 GLMHVVATNICVWIRTLVKESLLEITIYHQKNEPEAGASSIAHSIRQHALRHAGTVLRTHAGPNS 415
            |||..:|||:.:|:..:|.||:      ||           |||               ::|
Mouse   172 GLMFTLATNLAIWMAAVVDESV------HQ-----------AHS---------------YSG--- 201

  Fly   416 EFEVLDGEDILPKDVYKSDNVLSKLVRNTVDGISKSLGMGGDQALDSSTTSSSTTTTTRAPFTTP 480
                                                              |...|:.||
Mouse   202 --------------------------------------------------SHGNTSHTR------ 210

  Fly   481 NYQWHSTTMARKLKKFITSATTAATTAAGSSSTASSTTTISPTISSTTIPSTTISSTTISSSTTF 545
                                                                             
Mouse   211 ----------------------------------------------------------------- 210

  Fly   546 SPFSPSTTTTTTTTAAALNLETSGSESPFGGLQRILSSAAPPSLAPVDGFGSASAATPTSGSGAG 610
                                                                             
Mouse   211 ----------------------------------------------------------------- 210

  Fly   611 SFVDSFLASTLSPASSTEGSASIMNNLFGQGPMENSFQTYTDLGHEEATGLVSFENLESLDNIYP 675
                      |:|.|...|.|:                       ||..
Mouse   211 ----------LNPDSKRAGGAA-----------------------EEDP---------------- 226

  Fly   676 AALSSNIGTLNSTACGRIDIMGTIVYDSAPYLYPFIIEYSLIGAVVLYVMWKHIGRY-------- 732
                    .|.|||..:|...|..      |||||.|||||..:.:||||||::||.
Mouse   227 --------CLCSTAICQIFQQGYF------YLYPFNIEYSLFASTMLYVMWKNVGRLLASTHGHG 277

  Fly   733 --PGRMNDEDLEHRLEVMLSRRAVAMAQQARSGRVDCVGSSKGLFFGLLLLVGALICLILFFVLV 795
              |.|           |.|.|...                ..|...||||.|..|...||:.|.|
Mouse   278 HTPSR-----------VSLFRETF----------------FAGPVLGLLLFVVGLAVFILYEVQV 315

  Fly   796 ---RHQQFSLLAIYLADASHCI-LMAFAIL--AIIVGFIRVKNLKFRCEEQSNLNDILLRISAFG 854
               |......|.||.:....|: ||....|  ::|..|.| :.:.........|:..||..:|.|
Mouse   316 SGERGHTRQALVIYYSFNIVCLGLMTLVSLSGSVIYRFDR-RAMDHHKNPTRTLDVALLMGAALG 379

  Fly   855 LFT---YSVFSIIAGSLKVLESEPSLLVTTTGGVAVFQVILQLLFIADVSRR------------- 903
            .:.   ||:.:::.||.:.|:...:|   :...:.:.|...|.:||.:...|
Mouse   380 QYAISYYSIVAVVVGSPRDLQGALNL---SHALLMIAQHTFQNVFIIESLHRGPPGAEPREMPPK 441

  Fly   904 ------------------------RVHLPE----------------HDRSKPGRQIVTFLLICNV 928
                                    |:.:|.                |.|.:..:.|..|||:|||
Mouse   442 EPCQGITFANLDAIRTLPSCPPTPRLVIPNLESPQEAVAIISAPRCHWRRRCLKDISLFLLLCNV 506

  Fly   929 AMFAIYTFEAQKVFANPVQLEFYGFVPWSIIQRITLPLCIFHRFHSAVTLAEIW 982
            .::.:..|.|:..|:|.|:::|||:..|:.|..|.||..||:|.|:..:|.|::
Mouse   507 ILWIMPAFGARPHFSNTVEVDFYGYSLWAAIVNICLPFGIFYRMHAVSSLLEVY 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>405	CDD:281218	36/129 (28%)
		Otopetrin	<679..972	CDD:281218	93/364 (26%)
Otop2	NP_001349329.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		5/25 (20%)
		Otopetrin	103..549	CDD:397346	141/766 (18%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I4117
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8758
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	9.050