Protein Alignment OtopLa and Otop1

DIOPT Version :10

• Sequence 1: NP_001162676.1
• Gene: OtopLa / 8674066
• FlyBaseID: FBgn0259994
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_766297.2
• Gene: Otop1 / 21906
• MGIID: 2388363
• Length: 600
• Species: Mus musculus
• Alignment Length: 934
• Identity: 151/934 - (16%)
• Similarity: 252/934 - (26%)
• Gaps: 485/934 - (51%)

  Fly   195 GNGGSKPKPQPKEKKSKKAKN---ADPADSKD-AKGSKDSGKAAKGAAYQHTLAKFLEAPVDAEV 255
            |..|:...|......|:.|.:   |.|..... |:||..:....:||:....||:.|.:.....|
Mouse     3 GGPGAPSSPAASSGSSRAAPSGIAACPLSPPPLARGSPQASGPRRGASVPQKLAETLSSQYGLNV 67

  Fly   256 AVT--------------------------------------------PKNVRKRKTTHSDLTHGS 276
            .|.                                            .:.:.:.|.||:    |:
Mouse    68 FVAGLLFLLAWAVHATGVGKSDLLCVLTALMLLQLLWMLWYVGRSYMQRRLIRPKDTHA----GA 128

  Fly   277 FFLRVGAIAFGLGAMIYIGLEFGSFFEIPFDSPCHHILIGVNPLLQMIFTFMQMYFIFMNARLNI 341
            .:|| |:|.......:.:|....::| |.| |.|.....||.|:...:.|.:|:||::.:|:..|
Mouse   129 RWLR-GSITLFAFITVVLGCLKVAYF-IGF-SECLSATEGVFPVTHAVHTLLQVYFLWGHAKDII 190

  Fly   342 HRFKVIARFGLMHVVATNICVWIRTLVKESLLEITIYHQKNEPEAGASSIAHSIRQHALRHAGTV 406
            ..||.:.|||::|.|.||:.:|..:::.||      .||.||.:
Mouse   191 MSFKTLERFGVIHSVFTNLLLWANSVLNES------KHQLNEHK--------------------- 228

  Fly   407 LRTHAGPNSEFEVLDGEDILPKDVYKSDNVLSKLVRNTVDGISKSLGMGG-DQALDSSTTSSSTT 470
                                           .:|:         :||.|. ...||..|...:.|
Mouse   229 -------------------------------ERLI---------TLGFGNITIVLDDHTPQCNCT 253

  Fly   471 TTTRAPFTTPNYQWHSTTMARKLKKFITSATTAATTAAGSSSTASSTTTISPTISSTTIPSTTIS 535
                                                                             
Mouse   254 ----------------------------------------------------------------- 253

  Fly   536 STTISSSTTFSPFSPSTTTTTTTTAAALNLETSGSESPFGGLQRILSSAAPPSLAPVDGFGSASA 600
                                                              ||:|.
Mouse   254 --------------------------------------------------PPALC---------- 258

  Fly   601 ATPTSGSGAGSFVDSFLASTLSPASSTEGSASIMNNLFGQGPMENSFQTYTDLGHEEATGLVSFE 665
                                                                             
Mouse   259 ----------------------------------------------------------------- 258

  Fly   666 NLESLDNIYPAALSSNIGTLNSTACGRIDIMGTIVYDSAPYLYPFIIEYSLIGAVVLYVMWKHIG 730
                      :|||..|                  |    |||||.|||.::.:.:|||:||:||
Mouse   259 ----------SALSHGI------------------Y----YLYPFNIEYQILASTMLYVLWKNIG 291

  Fly   731 RYPGRMNDEDLEHRLEVMLSRRAVAMAQQARSGRVDCVGSSKGLFFGLLLLVGALICLILFFVLV 795
            |.......:.::.|.:.:|                  |||    ..||.:|...:..::::.:.:
Mouse   292 RRVDSSQHQKMQCRFDGVL------------------VGS----VLGLTVLAATIAVVVVYMIHI 334

  Fly   796 ----RHQQFSLLAIYLADASHCILMAFAILAIIVGFIRVKNLKFRCEEQS---------NLNDIL 847
                ...:.:|:..||...:..:||..|.|        |.:..:|.:|:|         .|:..|
Mouse   335 GRSKSKSESALIMFYLYAITVLLLMGAAGL--------VGSWIYRVDEKSLDESKNPARKLDVDL 391

  Fly   848 LRISAFGLFTYSVFSIIAGSLKVLESEP---------SLLVTTTGGVAVFQVILQLLFIADVSRR 903
            |..:..|.:..|..||:|  :...|:.|         |:||       :.:..:|.:||.:
Mouse   392 LVATGSGSWLLSWGSILA--IACAETRPPYTWYNLPYSVLV-------IVEKYVQNIFIIE---- 443

  Fly   904 RVHL-----PEHDRS----------------------------KPG------------------- 916
            .|||     ||..|:                            .|.
Mouse   444 SVHLEPEGVPEDVRTLRVVTVCSSEAAALAASTLGSQGMAQDGSPAVNGNLCLQQRCGKEDQESG 508

  Fly   917 -----------------------RQIVTFLLICNVAMFAIYTFEAQKVFANPVQLEFYGFVPWSI 958
                                   |.|..||.:||::::....|..:..:.|.::...:||.||.|
Mouse   509 WEGATGTTRCLDFLQGGMKRRLLRNITAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWII 573

  Fly   959 IQRITLPLCIFHRFHSAVTLAEIW 982
            :..:.:|..||:|.|:|..|.|::
Mouse   574 VVNLAMPFSIFYRMHAAAALFEVY 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>425	CDD:460840	35/146 (24%)
		Otopetrin	<673..972	CDD:460840	79/395 (20%)
Otop1	NP_766297.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..50		11/46 (24%)
		Otopetrin	131..586	CDD:460840	125/789 (16%)