Protein Alignment OtopLa and otpl-8

DIOPT Version :9

• Sequence 1: NP_001162676.1
• Gene: OtopLa / 8674066
• FlyBaseID: FBgn0259994
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_510045.2
• Gene: otpl-8 / 186752
• WormBaseID: WBGene00010403
• Length: 619
• Species: Caenorhabditis elegans
• Alignment Length: 890
• Identity: 177/890 - (19%)
• Similarity: 303/890 - (34%)
• Gaps: 394/890 - (44%)

  Fly   127 TSLFI--VTSLVYAILLIVVCIAYVISDVTTHRLPVLYYET-FFTYLYGVSILFLLYVFCFLLQE 188
            |:.|:  :||| ||::|.::.:...:|  .|.|..:...|| |:..:|||.|||..|.:.|::.
 Worm    61 TNFFVRLITSL-YALILTIISLVVEVS--PTWRTDMWLAETIFYISMYGVGILFFAYCYIFIIY- 121

  Fly   189 SSCCNGGNGGSKPKPQPKE------KKSKKAKNADPADSKDAKGSKDSGKAAKGAAYQHTLAKFL 247
                          |.|..      :|.|..||::                          ..|:
 Worm   122 --------------PGPYNQLISVLRKYKIIKNSE--------------------------VWFI 146

  Fly   248 EAPVDAEVAVTPKNVRKRKTTHSDLTHGSFFLRVGAIAFGLGAMIYIGLEFGSFFEIPFDSPCHH 312
                             .::.|:....|:.:||:||:.||...::..|||.....|   :..|..
 Worm   147 -----------------MQSQHNGEGAGTLYLRLGALFFGSVGIVLFGLELFLCIE---NVACKK 191

  Fly   313 ILIGVNPLLQMIFTFMQMYFIFMNARLNIHRFKVIARFGLMHVVATNICVWIRTLVKESLLEITI 377
            :.| ...::.::|||:||:|||.|:::.::..:.|..||:||:::.|:..|.|.::
 Worm   192 VAI-AKMIVAIVFTFIQMHFIFCNSKITVNSSRKIVAFGMMHLISVNLWTWFRFVL--------- 246

  Fly   378 YHQKNEPEAGASSIAHSIRQHALRHAGTVLRTHAGPNSEFEVLDGEDILPKDVYKSDNVLSKLVR 442
                             .:|.|..|....|:
 Worm   247 -----------------AKQEAKAHKKAQLK---------------------------------- 260

  Fly   443 NTVDGISKSLGMGGDQALDSSTTSSSTTTTTRAPFTTPNYQWHSTTMARKLKKFITSATTAATTA 507
                                                            :..:|:.
 Worm   261 ------------------------------------------------QTFRKYY---------- 267

  Fly   508 AGSSSTASSTTTISPTISSTTIPSTTISSTTISSSTTFSPFSPSTTTTTTTTAAALNLETSGSES 572
              |||::||:..|...||:  :.::|:::|            |:|.|.....:....||..|
 Worm   268 --SSSSSSSSEEIHELISA--VLNSTLNNT------------PATKTMEPVASRLFALEHFG--- 313

  Fly   573 PFGGLQRILSSAAPPSLAPVDGFGSASAATPTSGSGAGSFVDSFLASTLSPASSTEGSASIMNNL 637
                                                                             
 Worm   314 ----------------------------------------------------------------- 313

  Fly   638 FGQGPMENSFQTYTDLGHEEATGLVSFENLESLDNIYPAALSSNIGTLNSTACGRIDIMGTIVYD 702
                                                                            |
 Worm   314 ----------------------------------------------------------------D 314

  Fly   703 SAPYLYPFIIEYSLIGAVVLYVMWKHIGRYPGRMNDEDLEHRLEVMLSRRAVAMAQQARSG---- 763
            .|.:|...|:|||||||.:::::||.||:     |:.                  ||:.||
 Worm   315 VATFLTTCIVEYSLIGAAIMFILWKSIGQ-----NNH------------------QQSNSGKRKV 356

  Fly   764 --RVDCVGSSKGLFFGLLLLVGALICLILF--FVLVRHQQFSLLAIYLADASHCILMAFAILAII 824
              |:||..||.|||.|::.|:|:|:.:.::  |..:|:...:.|...:.|.|   |.:.|:.|.|
 Worm   357 KMRIDCSSSSTGLFAGIIFLIGSLVSMGMYTIFESLRNSSGAQLVFGIVDLS---LFSIALGACI 418

  Fly   825 VGFIRVKNLKFRCEEQSN-LNDILLRISAFGLFTY-----SVFSIIAGSLKVLESE-PSLLVTTT 882
            :|..|:::|::|...... :::|||.|...|...|     .||.....|..:..|. |:.:..
 Worm   419 IGLWRMRHLQYRLHAHGEVIDEILLIIGLIGEILYCAVGIDVFITCRRSADLTVSALPAFVFV-- 481

  Fly   883 GGVAVFQVILQLLFIADVSRRRVHLPEHDRSKPGRQIVTFLLICNVAMFAIYTFEAQKV---FAN 944
              :.:.||::|..||...||.|.......:.|||::|:||||:.||.:|..:|||..|.   |::
 Worm   482 --IRMIQVVVQAAFILTTSRLRCLSKYSMKYKPGKEIITFLLVSNVTLFVFHTFEGMKSSFGFSS 544

  Fly   945 PVQLEFYGFVPWSIIQRITLPLCIFHRFHSAVTLAEIWKTTYKAR 989
            ....: |.::.:::     .||.:|:||||:..||||||.||..:
 Worm   545 KAATQ-YNYIIYAV-----GPLLVFYRFHSSACLAEIWKHTYSTK 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>405	CDD:281218	32/126 (25%)
		Otopetrin	<679..972	CDD:281218	84/310 (27%)
otpl-8	NP_510045.2	Otopetrin	160..566	CDD:281218	134/711 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I2171
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I2203
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	1	1.000	-	-		FOG0001932
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.960