Protein Alignment OtopLa and otpl-7

DIOPT Version :9

• Sequence 1: NP_001162676.1
• Gene: OtopLa / 8674066
• FlyBaseID: FBgn0259994
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_505194.2
• Gene: otpl-7 / 185808
• WormBaseID: WBGene00018480
• Length: 627
• Species: Caenorhabditis elegans
• Alignment Length: 895
• Identity: 186/895 - (20%)
• Similarity: 313/895 - (34%)
• Gaps: 369/895 - (41%)

  Fly   119 ITGPIELWTSLFIVTSLVYAILLIVVCIAYVISDVTTHRLPVLYY-ETFFTYL-YGVSILFLLYV 181
            |..|..|...:.::||:...:|.||.|:   ||..:....|.|:. ||.|:.| |.::|||.:|.
 Worm    57 IRNPKALRFLVGLLTSMYVLLLTIVSCL---ISISSAWSSPDLWLAETIFSLLMYLIAILFFMYT 118

  Fly   182 FCFLLQESSCCNGGNGGSKPKPQPKEKKSKKAKNADPADSKDAKGSKDSGKAAKGAAYQHTLAKF 246
            :..::.             |||                                        ...
 Worm   119 YLMIIY-------------PKP----------------------------------------INM 130

  Fly   247 LEAPVDAEVAVTPKNVRKRKTTHSDLTH-----GSFFLRVGAIAFG-LGAMIYIGLEFGSFFEIP 305
            |...::.:.::.|   |..:...||..|     |:.:||:|||.|| ||::::     |....:.
 Worm   131 LIMILNRKTSLVP---RPDRWLLSDPIHNGEGAGTLYLRLGAIFFGTLGSVLW-----GCEIFLC 187

  Fly   306 FDSPCHHILIGVNPLLQMIFTFMQMYFIFMNARLNIHRFKVIARFGLMHVVATNICVWI-RTLVK 369
            |...|.|.|:....:..:||||:||:||..|:::..||..::|.||:||.||.|:..|. ..|||
 Worm   188 FSGECVHRLVVAKHIAAIIFTFLQMHFIVCNSKITFHRSNILASFGMMHCVAVNLWTWFSMCLVK 252

  Fly   370 ESLLEITIYHQKNEPEAGASSIAHSIRQHALRHAGTVLRTHAGPNSEFEVLDGEDILPKDVYKSD 434
            ..:.::.  .||.|.|..:||.:.|               .:..:|| |:|:.|.
 Worm   253 AQVKKLK--KQKKELEYHSSSSSSS---------------DSSSSSE-EILEPES---------- 289

  Fly   435 NVLSKLVRNTVDGISKSLGMGGDQALDSSTTSSSTTTTTRAPFTTPNYQWHSTTMARKLKKFITS 499
               |.|:.|.::.:.:.|..|          ..:|.|:|..|:|.
 Worm   290 ---STLLENLIEVVLEKLKPG----------KGTTYTSTPYPYTN-------------------- 321

  Fly   500 ATTAATTAAGSSSTASSTTTISPTISSTTIPSTTISSTTISSSTTFSPFSPSTTTTTTTTAAALN 564
                                                    ||:||
 Worm   322 ----------------------------------------SSNTT-------------------- 326

  Fly   565 LETSGSESPFGGLQRILSSAAPPSLAPVDGFGSASAATPTSGSGAGSFVDSFLASTLSPASSTEG 629
                                                                             
 Worm   327 ----------------------------------------------------------------- 326

  Fly   630 SASIMNNLFGQGPMENSFQTYTDLGHEEATGLVSFENLESLDNIYPAALSSNIGTLNSTACGRID 694
              |::.           .|:...||
 Worm   327 --SLLR-----------MQSMVRLG---------------------------------------- 338

  Fly   695 IMGTIVYDSAPYLYPFIIEYSLIGAVVLYVMWKHIGRYPGRMNDEDLEHRLEVMLSRRAVAMAQQ 759
                   |.:.:|...::|||||||.:.:::||::|.       .::|.:::           ::
 Worm   339 -------DFSSFLLTCLVEYSLIGAAICFIIWKYMGA-------TNIEMKVD-----------KK 378

  Fly   760 ARSGRVDCVGSSKGLFFGLLLLVGALICLILFFVLV--RHQQFSLLAIYLADASHCILMAFAILA 822
            .:..|:||..::.|||.|:..:..|.:.:.::.:|.  :..|.:.|.|.:.   :.||....:||
 Worm   379 KKKLRMDCHNTTIGLFLGIFFMTAAFVTIGIYTMLYNKKKTQSADLVIGIV---NLILFCVTLLA 440

  Fly   823 IIVGFIRVKNLKFRCEEQSN-LNDILLRISAFGLFTY-SV-FSIIAGSLKVLESEPSLLVTTTGG 884
            .|.|..|::.|::|...... :::|||.|...|...| |: |.:|....:.....|:|      .
 Worm   441 TIFGAWRMRVLQYRLHAHGEVIDEILLIIGLVGELIYCSIGFDMIVNGNRTGSHVPNL------P 499

  Fly   885 VAVF-----QVILQLLFIADVSRRRVHLPEHDRSKPGRQIVTFLLICNVAMFAIYTFEAQKVFAN 944
            :|||     |||:|.::|...||.|.....:.|::||:|.:|||::.|:.:|..:|||..|
 Worm   500 IAVFTFRIIQVIIQAMYILIASRLRCLSEVNARTQPGKQTLTFLVLINITLFVYHTFEGMK---- 560

  Fly   945 PVQLEFYGF-----VPWSIIQRITLPLCIFHRFHSAVTLAEIWKTTYKAR 989
                ..|||     ..:..:..|:.||.:|:||||:..||||||..|..:
 Worm   561 ----STYGFPALMETKYFELLNISSPLVVFYRFHSSACLAEIWKHAYSTK 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>405	CDD:281218	44/128 (34%)
		Otopetrin	<679..972	CDD:281218	76/307 (25%)
otpl-7	NP_505194.2	Otopetrin	164..589	CDD:281218	143/710 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I2171
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I2203
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	1	1.000	-	-		FOG0001932
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.930