Protein Alignment OtopLa and otpl-6

DIOPT Version :9

• Sequence 1: NP_001162676.1
• Gene: OtopLa / 8674066
• FlyBaseID: FBgn0259994
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_505195.1
• Gene: otpl-6 / 185807
• WormBaseID: WBGene00018479
• Length: 581
• Species: Caenorhabditis elegans
• Alignment Length: 899
• Identity: 175/899 - (19%)
• Similarity: 292/899 - (32%)
• Gaps: 371/899 - (41%)

  Fly   108 ITVQGTYETNPITGPIELWT-----SLFIVTSL--VYAILLIVVCIAYVISDVTTHRLPVLYYET 165
            :||...| ::.|...:..||     ..|.:.||  :|.::|.:|.....||.........:.|..
 Worm    20 VTVLTDY-SSTIPENLPAWTKNTKAQSFGLKSLTALYTLILTIVAFIIEISPTWQSESMNIEYTI 83

  Fly   166 FFTYLYGVSILFLLYVFCFLLQESSCCNGGNGGSKPKPQPKEKKSKKAKNADPADSKDAKGSKDS 230
            |...:|.::||:.:|::.::|
 Worm    84 FCVLMYSIAILYFIYLYAYIL-------------------------------------------- 104

  Fly   231 GKAAKGAAYQ---HTLAKFLEAPVDAEVAVTPKNVRKRKTTHSDLTHGSFFLRVGAIAFG-LGAM 291
                    |.   :|:..:||......|....:.|:.......: ..|:.:||:|.:.|| ||::
 Worm   105 --------YPIVFNTILLYLERMRVLNVHTVKRWVQPEPVFTGE-GAGTLYLRLGTVLFGTLGSV 160

  Fly   292 IYIGLEFGSFFEIPFDSPCHHILIGVNPLLQMIFTFMQMYFIFMNARLNIHRFKVIARFGLMHVV 356
            :: |.|....|   |....|:|.: |..:|..:||::||:|:..|:::::.:...:|.||:||.|
 Worm   161 LW-GCEIFLCF---FTETRHNIYV-VKYILAFLFTYLQMHFLCCNSKIDLPKNNFLASFGMMHCV 220

  Fly   357 ATNICVWIRTLVKESLLEITIYHQKNEPEAGASSIAHSIRQHALRHAGTVLRTHAGPNSEFEVLD 421
            |.|:.||.      ||
 Worm   221 AVNLWVWF------SL------------------------------------------------- 230

  Fly   422 GEDILPKDVYKSDNVLSKLVRNTVDGISKSLGMGGDQALDSSTTSSSTTTTTRAPFTTPNYQWHS 486
               .|.|.|||||....||.:                                   ....|:
 Worm   231 ---CLAKAVYKSDKKTLKLQK-----------------------------------AEEKYK--- 254

  Fly   487 TTMARKLKKFITSATTAATTAAGSSSTASSTTTISPTISSTTIPSTTISSTTISSSTTFSPFSPS 551
                   ||.:|.....|.|.         ||||:..:||             .||:.|
 Worm   255 -------KKNMTITEAVAETI---------TTTIASIVSS-------------ESSSGF------ 284

  Fly   552 TTTTTTTTAAALNLETSGSESPFGGLQRILSSAAPPSLAPVDGFGSASAATPTSGSGAGSFVDSF 616
                            ...|.....|.::               |||:               :|
 Worm   285 ----------------RADEKQLRSLYKL---------------GSAA---------------NF 303

  Fly   617 LASTLSPASSTEGSASIMNNLFGQGPMENSFQTYTDLGHEEATGLVSFENLESLDNIYPAALSSN 681
            |.:|:
 Worm   304 LLTTM------------------------------------------------------------ 308

  Fly   682 IGTLNSTACGRIDIMGTIVYDSAPYLYPFIIEYSLIGAVVLYVMWKHIGRYPGRMNDEDLEHRLE 746
                                          :|:|||.|.|.:::|||.|.
 Worm   309 ------------------------------VEFSLIAAAVYFIVWKHEGE--------------- 328

  Fly   747 VMLSRRAVAMAQQARSG--RVDCVGSSKGLFFGLLLLVGALICLILFFVLVRHQQFSLLAIYLAD 809
                    ...|.||..  |.||..:|.|:|..::||:|:.|.:.:.:: ..:......|..:..
 Worm   329 --------QTPQDARKKHVRFDCKSTSVGIFAAIVLLIGSFISIAMHYI-YNNSDMPRTADEVIG 384

  Fly   810 ASHCILMAFAILAIIVGFIRVKNLKFRCEEQSN-LNDILLRISAFGLFTYSVFSIIAGSLKVLES 873
            .:..:|....:||:...|||::.|::|...... :::|||.:...|...|....:.......||:
 Worm   385 IAETVLFCVCLLAVFGAFIRMRKLQYRLHAHGQVVDEILLIVGLAGEIVYCSTGLDLYLNGRLEN 449

  Fly   874 EP--SLLVTTTGGVAVFQVILQLLFIADVSRRRVHLPEHDRSKPGRQIVTFLLICNVAMFAIYTF 936
            .|  |.|......:.:.||::|.:||...||.|.....:..::||:||||||::||:.:|..:||
 Worm   450 TPGTSCLTVVAFVMRIVQVVVQSVFILVASRLRSLSASNISNQPGKQIVTFLVVCNINLFIYHTF 514

  Fly   937 EA-QKVFANPVQLEFYGFVPWSIIQRITLPLCIFHRFHSAVTLAEIWKTTYKAR 989
            |. :..|..|.::...    :|.:..|:.||.:|:||||:..||||||..|..:
 Worm   515 ETIESNFGFPHKMSSV----YSALLNISSPLVVFYRFHSSACLAEIWKHAYSKK 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>405	CDD:281218	33/127 (26%)
		Otopetrin	<679..972	CDD:281218	71/298 (24%)
otpl-6	NP_505195.1	Otopetrin	146..547	CDD:281218	136/700 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	175	1.000	Domainoid score	I2171
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	229	1.000	Inparanoid score	I2203
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	1	1.000	-	-		FOG0001932
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.930