Protein Alignment OtopLa and otpl-4

DIOPT Version :9

• Sequence 1: NP_001162676.1
• Gene: OtopLa / 8674066
• FlyBaseID: FBgn0259994
• Length: 991
• Species: Drosophila melanogaster
• Sequence 2: NP_505202.2
• Gene: otpl-4 / 185805
• WormBaseID: WBGene00018477
• Length: 558
• Species: Caenorhabditis elegans
• Alignment Length: 731
• Identity: 133/731 - (18%)
• Similarity: 201/731 - (27%)
• Gaps: 340/731 - (46%)

  Fly   277 FFLRVGAIAFGLGAMIYIGLE-FGSFFEIPFDSPCHHILIGVNP-------LLQMIFTFMQMYFI 333
            ||||:|||.|.:||::...:| |.:|.:            .|.|       .|.:||...|:.|:
 Worm    86 FFLRLGAIFFSIGAIVLWSIELFLAFAQ------------SVRPWICILRTCLYIIFHVTQVVFV 138

  Fly   334 FMNARLNIHRFKVIARFGLMHVVATNICVWIRTLVKESLLEITIYHQKNEPEAGASSIAHSIRQH 398
            .::.|:..|..::|..|||.|.:|.|:.:|....:.:|    .|.:.:||       ..|.:..|
 Worm   139 SISHRVEFHYHRMIVYFGLSHTIAVNLWIWASLCIAKS----GIGNNQNE-------TYHIVFDH 192

  Fly   399 ALRHAGTVLRTHAGP---NSEFEVLDGEDILPKDVYKSDNVLSKLVRNTVDGISKSLGMGGDQAL 460
               |:..|:.:...|   |..||             |.:..|     .||    |..|
 Worm   193 ---HSPWVMHSTDQPIVVNLTFE-------------KYEYTL-----RTV----KYFG------- 225

  Fly   461 DSSTTSSSTTTTTRAPFTTPNYQWHSTTMARKLKKFITSATTAATTAAGSSSTASSTTTISPTIS 525
                       :|...|.|.|.::........|..|.|.|
 Worm   226 -----------STSIIFLTLNVEFCLIAFGACLCLFYTIA------------------------- 254

  Fly   526 STTIPSTTISSTTISSSTTFSPFSPSTTTTTTTTAAALNLETSGSESPFGGLQRILSSAAPPSLA 590
                                  :.||............:...:|.....|....|||..:
 Worm   255 ----------------------WEPSLHDHKKNHYIGFDYRNTGIGMLLGFCMLILSCLS----- 292

  Fly   591 PVDGFGSASAATPTSGSGAGSFVDSFLASTLSPASSTEGSASIMNNLFGQGPMENSFQTYTDLGH 655
                                                                             
 Worm   293 ----------------------------------------------------------------- 292

  Fly   656 EEATGLVSFENLESLDNIYPAALSSNIGTLNSTACGRIDIMGTIVYDSAPYLYPFIIEYSLIGAV 720
                  |:|.|: ..||.|..|....:|                ::..|.||...     |...:
 Worm   293 ------VAFGNI-LRDNDYQKAAGEVVG----------------IFQLAYYLISI-----LTCGI 329

  Fly   721 VLYVMWKHIGRYPGRMNDEDLEHRLEVMLSRRAVAMAQQARSGRVDCVGSSKGLFFGLLLLVG-- 783
            |...::|||                  :|::..|.      |...|.:...|.:.. :.||||
 Worm   330 VFQCLFKHI------------------ILNQEFVI------SPNRDLMPHEKNINI-IFLLVGVC 369

  Fly   784 --ALICLILFFVLVRHQQFSLLAIYLADASHCILMAFAILAIIVGFIRVKNLKFRCEEQSNLNDI 846
              .:.|.:....::|..|       |.|....::.:|...||                     ::
 Worm   370 GEVMYCCMGLLGVIRGDQ-------LLDTKGIVIASFLTRAI---------------------EV 406

  Fly   847 LLRISAFGLFTYSVFSIIAGSLKVLESEPSLLVTTTGGVAVFQVILQLLFIADVSRRRVHLPEHD 911
            |  |.|..||                    .|:...|.|.....|
 Worm   407 L--IQAILLF--------------------YLLKKGGSVEPCDTI-------------------- 429

  Fly   912 RSKPGRQIVTFLLICNVAMFAIYTFEAQKVFANPVQLEFYGFVPWSI------IQRITLPLCIFH 970
                |:|.:|||:..|:.:|..:..|.        .:..||| |..|      ..:|.|||.:|.
 Worm   430 ----GKQSITFLIALNMILFGFHAIEG--------SIRTYGF-PTKIDDTSKMFLKICLPLVVFF 481

  Fly   971 RFHSAVTLAEIWKTTY 986
            |||.:|..|||||..|
 Worm   482 RFHCSVCFAEIWKVYY 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>405	CDD:281218	36/134 (27%)
		Otopetrin	<679..972	CDD:281218	53/302 (18%)
otpl-4	NP_505202.2	Otopetrin	87..483	CDD:281218	122/714 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4740
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	1	1.000	-	-		FOG0001932
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR21522
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.970