DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment OtopLa and LOC100496487

DIOPT Version :9

Sequence 1:	NP_001162676.1	Gene:	OtopLa / 8674066	FlyBaseID:	FBgn0259994	Length:	991	Species:	Drosophila melanogaster
Sequence 2:	XP_017953313.2	Gene:	LOC100496487 / 100496487	-ID:	-	Length:	655	Species:	Xenopus tropicalis

Alignment Length:	1054	Identity:	175/1054 - (16%)
Similarity:	296/1054 - (28%)	Gaps:	505/1054 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 PRETLQLENMERANL------LDNRQSASESN---QLQGDGYHTSPAHQRTPLVPHDLGEDFNLD 73
            |.|.:::..:.:.:|      .|:::.|:..|   ::........|..:....|||...:|
Frog    17 PSEVMEMPQISKKDLDAPHTNSDDQEEANMPNREQEMPNKALEMPPTAKEGMNVPHINNKD---- 77

  Fly    74 FDDDFPIDARRPKNAKVCYTFKPNPNKYSFMPAKI------------TVQGTYETNPITGPIELW 126
                  .|..:|          |......::||::            ::|.....:| :|..|:|
Frog    78 ------SDMSQP----------PYEGALPYLPAQVMNPESSEAQMDLSLQNQTTASP-SGHSEVW 125

  Fly   127 TSLFIVTSLVYAILLIVVCIAYVISDVTTHRLPVLYYETFFTYLYGVSILFLLYVFCFLLQESSC 191
            .....:.|.:.||.:.:.....|.|....|  .|:..:....:|.   :|.||.||..:.|....
Frog   126 KKGGRLLSALMAINIALFGSVLVSSGSLEH--VVVQDKEVLAFLV---VLMLLSVFWMIFQFYFS 185

  Fly   192 CNGGNGGSKPKPQPKEKKSKKAKNADPADSKDAKGSKDSGKAAKGAAYQHTLAKFLEAPVDAEVA 256
            |.
Frog   186 CQ--------------------------------------------------------------- 187

  Fly   257 VTPKNVRKRKTTHSDLTHGSFFLRVGAIAFGLGAMIYIGLEFGSFFE-IPFDSPCHHILIGVNPL 320
               ||....|.:|:    |..:||.|.:.||:.:::....:.|.:.. |..:||...|    :|:
Frog   188 ---KNAVLYKDSHA----GPVWLRGGLVFFGICSLVMDVFKIGYYISYIDCESPIKLI----HPM 241

  Fly   321 LQMIFTFMQMYFIFMNARLNIHRFKVIARFGLMHVVATNICVWIRTLVKESLLEITIYHQKNEPE 385
            :|..|..||.||::::::..:.....|:|:|||.::.||:.:|:..:..||:      ||..:.|
Frog   242 VQSAFIIMQTYFLWVSSKHCVQIHTNISRYGLMLILITNLSIWMAAVTDESV------HQTRDLE 300

  Fly   386 AGASSIAHSIRQHALRHAGTVLRTHAGPNSEFEVLDGEDILPKDVYKSDNVLSKLVRNTVDGISK 450
            ..     |.|             .|:.|
Frog   301 DD-----HKI-------------VHSSP------------------------------------- 310

  Fly   451 SLGMGGDQALDSSTTSSSTTTTTRAPFTTPNYQWHSTTMARKLKKFITSATTAATTAAGSSSTAS 515
                                                                     |||..
Frog   311 ---------------------------------------------------------AGSHD--- 315

  Fly   516 STTTISPTISSTTIPSTTISSTTISSSTTFSPFSPSTTTTTTTTAAALNLETSGSESPFGGLQRI 580
                                                            :.|..|:.
Frog   316 ------------------------------------------------HKEVGGAH--------- 323

  Fly   581 LSSAAPPSLAPVDGFGSASAATPTSGSGAGSFVDSFLASTLSPASSTEGSASIMNNLFGQGPMEN 645
                                                                           |:
Frog   324 ---------------------------------------------------------------EH 325

  Fly   646 SFQTYTDLGHEEATGLVSFENLESLDNIYPAALSSNIGTLNSTACGRIDIMGTIVYDSAPYLYPF 710
            :.|....|.|...||..                                           |||||
Frog   326 TCQCSNHLCHIFQTGYY-------------------------------------------YLYPF 347

  Fly   711 IIEYSLIGAVVLYVMWKHIGRYPGRMNDEDLEHRLEVMLSRRAVAMAQQARSGRVDCVGSSKGLF 775
            .|||||..:.:.|||||::||   .|:|                   |.|...|:......|.:|
Frog   348 NIEYSLFASAMTYVMWKNVGR---EMDD-------------------QVAHHSRLSLCFYFKNMF 390

  Fly   776 FGLLLLVGALICLILFFVLVRHQQFSLLAIYLAD---ASHCILMAFAILAI-------IVGFIRV 830
            .|.|:....|:|.::..|:.:      :.|.|.|   .:|.:..:|.|||:       :.|.|..
Frog   391 AGFLIGGAVLLCGVVVLVIYK------VKINLPDKLYRAHILFYSFNILALALMSLGSLAGSIIY 449

  Fly   831 KNLKFRCEEQSN----LNDILLRISAFGLFTYSVFSIIAGSLKVLESEPSLLVTTTGGV----AV 887
            :..|...:...|    |:..||..:|.|.:..|.:||:|    ::.:.|..|:.....|    .:
Frog   450 RFDKRHMDAHKNPTRTLDVTLLLGAALGQYCISYYSIVA----MVATSPGELINALNLVYSILMI 510

  Fly   888 FQVILQLLFIADVSRRR-----VHLPE---------------HDRSKPG---------------- 916
            .|:.||..||.:...|.     ...||               |:.: ||
Frog   511 VQLTLQNTFIIEGLHREPFQDAAPQPEKGLIFANEAVAPSLAHNET-PGFSAPAPEFPAKPKQSI 574

  Fly   917 ------------RQIVTFLLICNVAMFAIYTFEAQKVFANPVQLEFYGFVPWSIIQRITLPLCIF 969
                        ::|..|||:||:.::.:..|.|:....|.::..|||...|:||..|.||..||
Frog   575 TEPPWNLKRRMVQEISLFLLLCNIILWLMPAFGARPQLKNNLERNFYGLYVWTIITNICLPFGIF 639

  Fly   970 HRFHSAVTLAEIWK 983
            :|.|:|.:|.|:::
Frog   640 YRMHAAASLLEVFR 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
OtopLa	NP_001162676.1	Otopetrin	278..>405	CDD:281218	32/127 (25%)
OtopLa	NP_001162676.1	Otopetrin	<679..972	CDD:281218	84/358 (23%)
LOC100496487	XP_017953313.2	Otopetrin	203..641	CDD:397346	129/758 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	169	1.000	Inparanoid score	I4017
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D243107at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9424
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3542
SonicParanoid	1	1.000	-	-		X278
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.000