DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mgl and DGCR2

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_005128.1 Gene:DGCR2 / 9993 HGNCID:2845 Length:550 Species:Homo sapiens


Alignment Length:638 Identity:129/638 - (20%)
Similarity:190/638 - (29%) Gaps:224/638 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1189 CGSNEFQCRSG--RCIPQNFRCDQENDCGDNSDEQECGNVTCGTSQFACANGRCIPNMWK--CDS 1249
            |...:|.||||  :|||..::||....|.|.|||..|..||          |...|:..|  .|.
Human    30 CNPGQFACRSGTIQCIPLPWQCDGWATCEDESDEANCPEVT----------GEVRPHHGKEAVDP 84

  Fly  1250 ENDCGDSSDEGDFCAEKTCAYFQFT-----CPRTGHCIPQSWVC-----------DGDDDC---- 1294
            ........|...|.|.......:|:     ||...|....:..|           |....|    
Human    85 RQGRARGGDPSHFHAVNVAQPVRFSSFLGKCPTGWHHYEGTASCYRVYLSGENYWDAAQTCQRLN 149

  Fly  1295 -------------FDKQDEKDCPPISCLANQFKCADLRQC-VEESYKCDGIPDCNDGSDEVGCPS 1345
                         |....|.|.|..|     |...|.|:. |...|...|.....:|..||.   
Human   150 GSLATFSTDQELRFVLAQEWDQPERS-----FGWKDQRKLWVGYQYVITGRNRSLEGRWEVA--- 206

  Fly  1346 MGPNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSDHSDEQDCGQITC-------AQNFFKCNNTN 1403
                       |:..|..|..|........::    :|...|.|:.|       ..:....:..:
Human   207 -----------FKGSSEVFLPPDPIFASAMSE----NDNVFCAQLQCFHFPTLRHHDLHSWHAES 256

  Fly  1404 CVFK-AYICDGKDDCGDNSDEGAEHACVPPPFKCPHGQWQCPGVSERCVNITSVCDDTPDCPNGS 1467
            |..| :::|.....|.|..|...:           .|.:..|...:.|::.|        |..| 
Human   257 CYEKSSFLCKRSQTCVDIKDNVVD-----------EGFYFTPKGDDPCLSCT--------CHGG- 301

  Fly  1468 DEGEGCDLAECEHQAGQCSSFCQKTPNGALCVCPPGSEIGEDGYTCIDSNECDPPGLCSQQCTNT 1532
             |.|.|..|.||...|     ||:...                    |..||     |...|.:.
Human   302 -EPEMCVAALCERPQG-----CQQYRK--------------------DPKEC-----CKFMCLDP 335

  Fly  1533 KG-SYFCSCTDGYVLEPNKHTCKAVNHTAAFLIISNRHSILVADLKEQGLERVPIIVENVVATAS 1596
            .| |.|.|...|..|        .|:..::|||:| ....:|..|:::..||:..::      .:
Human   336 DGNSLFDSMASGMRL--------VVSCISSFLILS-LLLFMVHRLRQRRRERIESLI------GA 385

  Fly  1597 NMHTGTIFWSDMKLKKISRLDRGMEPQEIINTGL------DLVEG------------LAYDW--I 1641
            |:|...:.      ::|...|.|.:.   ..|||      |..||            .||.:  |
Human   386 NLHHFNLG------RRIPGFDYGPDG---FGTGLTPLHLSDDGEGGTFHFHDPPPPYTAYKYPDI 441

  Fly  1642 AQ---------------NLYW---LDSKLNTIEVS----AENGSNRLVLVRENITQP-------- 1676
            .|               ::::   .|.....:|||    .:.||...:|.|  :.||        
Human   442 GQPDDPPPPYEASIHPDSVFYDPADDDAFEPVEVSLPAPGDGGSEGALLRR--LEQPLPTAGASL 504

  Fly  1677 ----------RGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKI 1719
                      ..:.:.|.|...       |..|..|.:...|...::.:||.:
Human   505 ADLEDSADSSSALLVPPDPAQS-------GSTPAAEALPGGGRHSRSSLNTVV 550

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486 16/35 (46%)
LDLa 1227..1259 CDD:197566 5/33 (15%)
LDLa 1268..1303 CDD:238060 9/67 (13%)
LDLa 1308..1343 CDD:238060 9/35 (26%)
LDLa 1356..1387 CDD:238060 5/30 (17%)
LDLa 1391..1423 CDD:197566 6/39 (15%)
LDLa 1435..1469 CDD:197566 6/33 (18%)
FXa_inhibition 1478..1513 CDD:291342 5/34 (15%)
FXa_inhibition 1522..1553 CDD:291342 8/31 (26%)
LY 1625..1665 CDD:214531 16/81 (20%)
LY 1667..1711 CDD:214531 10/61 (16%)
Ldl_recept_b 1690..1728 CDD:278487 6/30 (20%)
LY 1712..1754 CDD:214531 2/8 (25%)
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
cEGF 3269..3292 CDD:289433
vWFA <3284..3324 CDD:294047
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:291342
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
DGCR2NP_005128.1 LDLa 30..66 CDD:238060 16/35 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 69..92 6/32 (19%)
CLECT_DGCR2_like 115..267 CDD:153069 31/174 (18%)
VWC 271..329 CDD:214564 21/108 (19%)
Atrophin-1 <428..537 CDD:331285 19/117 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 500..550 8/56 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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