back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mgl and FBN3

DIOPT Version :10

Sequence 1:	NP_572563.3	Gene:	mgl / 8674055	FlyBaseID:	FBgn0261260	Length:	4769	Species:	Drosophila melanogaster
Sequence 2:	XP_016882868.1	Gene:	FBN3 / 84467	HGNCID:	18794	Length:	2851	Species:	Homo sapiens

Alignment Length:	3548	Identity:	674/3548 - (18%)
Similarity:	945/3548 - (26%)	Gaps:	1605/3548 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly  1076 ADTQPCHR------NNGGCQKI--CFAVPIGASNGTDGVTTSSPSFGRLQSRCSCPYGERLADDQ 1132
            |...||.|      :.|.||.:  |.||| |...|...|.... ||     .|.||.|.||:|..
Human   227 AQPHPCRRGFIPNIHTGACQDVDECQAVP-GLCQGGSCVNMVG-SF-----HCRCPVGHRLSDSS 284

  Fly  1133 VSCIPDPSAEPPVQPCPNSWDFTCNNQRCIPKSWLCDGDDDCLDNSDEEQNCTKPTCGSNEFQCR 1197
            .:|.                    :...|:..|.||.|.|           ||. |.||....|.
Human   285 AACE--------------------DVNECLSLSGLCSGGD-----------CTN-TVGSYVCTCS 317

  Fly  1198 SGRCIPQNFRCDQENDCGDNSDEQECGNVTCGTSQFACANGRCIPNMWKCDSENDCGDSSDEGDF 1262
            .|              ...:.|...|.|...|........|||            .||.:  |.:
Human   318 QG--------------FASSLDGTHCLNYRAGACFSVLFGGRC------------AGDLA--GHY 354

  Fly  1263 CAEKTCAYFQFTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPPISCLANQFKCADLRQCVEESYK 1327
            ...:.|      |.| |.|    |......:.        |||..  :|:|:    :.|.:....
Human   355 TRRQCC------CDR-GRC----WAAGPVPEL--------CPPRG--SNEFQ----QLCAQRLPL 394

  Fly  1328 CDGIPDC----------------------NDGSDEVGCPSMGPNQCNLE-----------KHFRC 1359
            ..|.|..                      ..|||..|.||:||...|:.           :||
Human   395 LPGHPGLFPGLLGFGSNGMGPPLGPARLNPHGSDARGIPSLGPGNSNIGTATLNQTIDICRHF-- 457

  Fly  1360 KSTGFCI-------PIAWHCDGSNDCSDHSDEQDCGQITCAQNFFKCNNTNCVFKAYICDGKDDC 1417
              |..|:       |.::.|:                         ||      ..|..|.:.:|
Human   458 --TNLCLNGRCLPTPSSYRCE-------------------------CN------VGYTQDVRGEC 489

  Fly  1418 GDNSDEGAEHACVPPPFKCPHGQWQCPGVSERCVNI--TSVCDDTPDCPNGSDEGEGC-DLAECE 1479
            .| .||     |...|  |.||.         ||||  |..|...|.. ..:...:.| |:.||.
Human   490 ID-VDE-----CTSSP--CHHGD---------CVNIPGTYHCRCYPGF-QATPTRQACVDVDECI 536

  Fly  1480 HQAGQCS-SFCQKTPNGALCVCPPGSEIGEDGYTCIDSNECDPPGLC-SQQCTNTKGSYFCSCTD 1542
            ...|.|. ..|..|.....|||..|.|:..||..|:|.|||....:| :..|.|..||:.|.|..
Human   537 VSGGLCHLGRCVNTEGSFQCVCNAGFELSPDGKNCVDHNECATSTMCVNGVCLNEDGSFSCLCKP 601

  Fly  1543 GYVLEPNKHTCKAVNHTAAFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGTIFWSD 1607
            |::|.|..|.|..::......|..|.|.                             |.|  ...
Human   602 GFLLAPGGHYCMDIDECQTPGICVNGHC-----------------------------TNT--EGS 635

  Fly  1608 MKLKKISRLDRGMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVREN 1672
            .:.:.:..|..|.:.:..::|.   |....|              ..||
Human   636 FRCQCLGGLAVGTDGRVCVDTH---VRSTCY--------------GAIE---------------- 667

  Fly  1673 ITQPRGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRVYFA 1737
                :|.|..|.|                      ||:.|:
Human   668 ----KGSCARPFP----------------------GTVTKS------------------------ 682

  Fly  1738 DSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGKNQTVVS 1802
                   :.|..|
Human   683 -------ECCCAN---------------------------------------------------- 688

  Fly  1803 HLISQPLSIHVHHASLQPMTPNPCAGSRCQHLCLLSPSAPEGYSCKCRPGFKLLSEGRCIEEENP 1867
                                |:...|..|| ||....||.  :...|..|..:.::||.|.|
Human   689 --------------------PDHGFGEPCQ-LCPAKDSAE--FQALCSSGLGITTDGRDINE--- 727

  Fly  1868 FLMVVKGTQIVDLPLNGGDARAGALAPVIGIESSTGLDFDRKGETLYWVQGREDDDENCTIYTTP 1932
                                  .||                             |.|.|
Human   728 ----------------------CAL-----------------------------DPEVC------ 735

  Fly  1933 YGGGNKTLFLGIENGIVGAPYTIAFDWLGRNLYIGNRVASNIEAVRVDGKQKYRTIILANDGYPN 1997
                                              .|.|..|:       :..||.:  .|.||..
Human   736 ----------------------------------ANGVCENL-------RGSYRCV--CNLGYEA 757

  Fly  1998 SVSRPKQIALDPTEGKLFWIDEGVLEVPIKIGRVDMNGQNPIVVFQEFAHPESLAVDT---EKKM 2059
            ..|     ..|.|:     :||..|                          .||..|.   :...
Human   758 GAS-----GKDCTD-----VDECAL--------------------------NSLLCDNGWCQNSP 786

  Fly  2060 VYYSASNPAVIGVMDYNGDDHTLILMKDSHPMAKPRSLGILDHRLYYLDPLYERIVRIDLPHGDN 2124
            ..||.|.|.  |...:...:    :.||
Human   787 GSYSCSCPP--GFHFWQDTE----ICKD------------------------------------- 808

  Fly  2125 PKTIVDNESDLRSMMIYKKRALMQHPCQTNNGGCKHLCIPGPGATRTCACGIGYRKENEINCVAY 2189
                ||.              .:..||.  :|.|::|     ..:.||.||.|
Human   809 ----VDE--------------CLSSPCV--SGVCRNL-----AGSYTCKCGPG------------ 836

  Fly  2190 KIFAVVSQLDMIRGYSLSDSSEAMVPISGPGHHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPN 2254
                  |:||                                                     |:
Human   837 ------SRLD-----------------------------------------------------PS 842

  Fly  2255 GTDLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTDAPREL 2319
            ||                 ..:|...|               .|||     |:
Human   843 GT-----------------FCLDSTKG---------------TCWL-----KI------------ 858

  Fly  2320 AVNPIKRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHDIYWVDSKLDTIQK 2384
                           |..|.                                            :
Human   859 ---------------QESRC--------------------------------------------E 864

  Fly  2385 ISYNGANRKIIRRDLPNPMGIAVYLNDVYWVDRNLMTVFKASKHSANETATSVRTNLEKLRDIAI 2449
            ::..||:   :|.:....:|.|       |          .|.....|...:......::..:..
Human   865 VNLQGAS---LRSECCATLGAA-------W----------GSPCERCEIDPACARGFARMTGVTC 909

  Fly  2450 YNINNQPQDDTNPCAHLGNGGCDQLCFSFP---PDGGASGTSGGRNFRCEC-------ATGKLSA 2504
                    ||.|.|.            |||   |:|....|:|  :|||||       |:|:|..
Human   910 --------DDVNECE------------SFPGVCPNGRCVNTAG--SFRCECPEGLMLDASGRLCV 952

  Fly  2505 -----------DERKCEVV--NEYLVFATRTEIRAV-------NLDPHSTEVPFTPLTNLTNVVG 2549
                       ||.:|.|.  .:|.:......|.||       ..||.|.|  |..|...    |
Human   953 DVRLEPCFLRWDEDECGVTLPGKYRMDVCCCSIGAVWGVECEACPDPESLE--FASLCPR----G 1011

  Fly  2550 LDF---DFAHNRMLYTQIRPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQQKIYWTDSS 2611
            |.|   ||...|..|                           |.:|         :.|::
Human  1012 LGFASRDFLSGRPFY---------------------------KDVN---------ECKVF----- 1035

  Fly  2612 NNSIYAMNLDGSELVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIVDK 2676
                                  |.......|..|:        |:    |....||
Human  1036 ----------------------PGLCTHGTCRNTV--------GS----FHCACAG--------- 1057

  Fly  2677 DLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATIYPFAITVFRNYIYWTDLQLR 2741
                  |.|:|..||..  ||....:|. .||.||.                       |.:...
Human  1058 ------GFALDAQERNC--TDIDECRIS-PDLCGQG-----------------------TCVNTP 1090

  Fly  2742 GVYRAEKHTGANMVEMVKRLEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGKAECKC 2806
            |.:..|...|.....|:.:          ...|..:|..:|.....|.|..:     :|..:|:|
Human  1091 GSFECECFPGYESGFMLMK----------NCMDVDECARDPLLCRGGTCTNT-----DGSYKCQC 1140

  Fly  2807 DDSTKVVNEGRMCAPRNNTCEASKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNE 2871
            ....::..:|..|...:. |..|...|.:|:|::.:.:.......|..|..|...|.    ..||
Human  1141 PPGHELTAKGTACEDIDE-CSLSDGLCPHGQCVNVIGAFQCSCHAGFQSTPDRQGCV----DINE 1200

  Fly  2872 FRCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGR---CIPQAQVCNGVNDCKD 2933
            .|..||.|                  ::.|:.   .:|.:.|:.|:   .:|..:.|..|::|::
Human  1201 CRVQNGGC------------------DVHCIN---TEGSYRCSCGQGYSLMPDGRACADVDECEE 1244

  Fly  2934 N-ATSDETH-------ERC----------PMNT-----TCPAN-----HLKCEKTN-----ICVE 2965
            | ...|:.|       .||          .|.|     .|..|     |..||.|.     .|..
Human  1245 NPRVCDQGHCTNMPGGHRCLCYDGFMATPDMRTCVDVDECDLNPHICLHGDCENTKGSFVCHCQL 1309

  Fly  2966 PYWLCDGDNDCGDNSDEDPLHCGQRTCPTN--------SFRCPNHRCIPATWYCDGD-----DDC 3017
            .|.:..|...|   ||.|....|...|.::        ||.|   ||:|. |..||.     |:|
Human  1310 GYMVRKGATGC---SDVDECEVGGHNCDSHASCLNIPGSFSC---RCLPG-WVGDGFECHDLDEC 1367

  Fly  3018 ----------GDGADEPPDY-CKSEGRTC----FGDLFTC-DNGNCIPRIYICDGDNDCLDNSDE 3066
                      ||..:.|..| |     ||    .||.|.| |...|...:.:|| :..|| |:..
Human  1368 VSQEHRCSPRGDCLNVPGSYRC-----TCRQGFAGDGFFCEDRDECAENVDLCD-NGQCL-NAPG 1425

  Fly  3067 DNRHQC--------NDRKCDEETEFTCVENKSWQRAQC--IPK--KWICDGDPDCVDGADENTTL 3119
            ..|.:|        :.|.|.:..|  |.:........|  :|.  :.||:|..:...|....|.:
Human  1426 GYRCECEMGFDPTEDHRACQDVDE--CAQGNLCAFGSCENLPGMFRCICNGGYELDRGGGNCTDI 1488

  Fly  3120 HNCATQQPCGEDMFTCGNGRCINK--GWICDHDNDCGDGTDEGKFC-NSKYKTCSAQEFTCQNFK 3181
            :.||       |...|.||.|||.  .::|....|. :....|..| :::...|
Human  1489 NECA-------DPVNCINGVCINTPGSYLCSCPQDF-ELNPSGVGCVDTRAGNC----------- 1534

  Fly  3182 CIRNQSRCDGEDDCGDHSDE--VGCAKENITCPQGQF------ACTNGQCIDYNLVCNKYPDCAD 3238
            .:....|.|....|   |.|  ||..:.:..|..|:.      .|......:|..:|.     ..
Human  1535 FLETHDRGDSGISC---SAEIGVGVTRASCCCSLGRAWGNPCELCPMANTTEYRTLCP-----GG 1591

  Fly  3239 ESDEPAHC-----NVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPG 3298
            |..:|...     ::|||.::.....|..||:|...:.|:|..||.|....:.|.|:|||....|
Human  1592 EGFQPNRITVILEDIDECQELPGLCQGGDCVNTFGSFQCECPPGYHLSEHTRICEDIDECSTHSG 1656

  Fly  3299 ACSQ-HCSNTPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNLMHQ 3362
            .|.. .|.||.|.:.|.|...|.: .|..:.|....|                ||....||...|
Human  1657 ICGPGTCYNTLGNYTCVCPAEYLQ-VNGGNNCMDMRK----------------SVCFRHYNGTCQ 1704

  Fly  3363 DLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAIDWVGRK 3427
            :     .|.|::..: |..|.......:..........:.|:.:.:..:.:.|
Human  1705 N-----ELAFNVTRK-MCCCSYNIGQAWNRPCEACPTPISPDYQILCGNQAPG------------ 1751

  Fly  3428 LYWLDRHS-KNLDVSELDGSKRKTLRSGVVDPRAIVVHPGIGYLYFTSWHLQAYIAKMGM----- 3486
             :..|.|: |.||:.|. |.......:|:.                        |.::|.
Human  1752 -FLTDIHTGKPLDIDEC-GEIPAICANGIC------------------------INQIGSFRCEC 1790

  Fly  3487 -DGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVLSGSK------ 3544
             .|.|::.||     :|..:   :|....|......:.|.|   ::.|.:|.....|.|
Human  1791 PAGFNYNSIL-----LACED---VDECGSRESPCQQNADCI---NIPGSYRCKCTRGYKLSPGGA 1844

  Fly  3545 ---------VPHVFALSLFDDYIYWSDWNLKAIVRANKFHG------ANYTVLRNTTHRPYDLHI 3594
                     :|:|.:                        ||      .:|..|   .||.:....
Human  1845 CVGRNECREIPNVCS------------------------HGDCMDTEGSYMCL---CHRGFQASA 1882

  Fly  3595 NHPL--------RQLPYTNPCGTNNGGC-----SHLCLIAPP------------PESTYLNIE-- 3632
            :..|        ||     |||  ||.|     |:.||..|.            .|.|.|..:
Human  1883 DQTLCMDIDECDRQ-----PCG--NGTCKNIIGSYNCLCFPGFVVTHNGDCVDFDECTTLVGQVC 1940

  Fly  3633 --GYIEEGAPIFKCACPNQFYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSD 3695
              |:....|..|.|.|.:.|.|..|.|.||                            |..:...
Human  1941 RFGHCLNTAGSFHCLCQDGFELTADGKNCV----------------------------DTNECLS 1977

  Fly  3696 EPATCAPRHCR--AGTFQCKNTNCTPSATI----CDGVDDCGDRSDEQNCDL--PCPLS--DFKC 3750
            ...||.|..|:  .|:|:|   .|.|...:    |..:|:|   |:|.|..|  .|..|  .|:|
Human  1978 LAGTCLPGTCQNLEGSFRC---ICPPGFQVQSDHCIDIDEC---SEEPNLCLFGTCTNSPGSFQC 2036

  Fly  3751 KSSGRCIL--DSWRCDGDADCKDGSDEDPAVCFKR----TCDPKTEFSCKNGRCIPQLWMCDFDN 3809
            ......:|  :..||         .|...:.||.|    .|.....|:....||      |
Human  2037 LCPPGFVLSDNGHRC---------FDTRQSFCFTRFEAGKCSVPKAFNTTKTRC------C---- 2082

  Fly  3810 DC----GDDSDEPAYMCRQRNCTTGWQRCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENCPKC- 3869
             |    |:...:|..:|.|.......:.||  ..:..:|      |.||.|::.:|..||...|
Human  2083 -CSKRPGEGWGDPCELCPQEGSAAFQELCP--FGHGAVP------GPDDSREDVNECAENPGVCT 2138

  Fly  3870 -----NPETDFKC-----------GNNRCIPKQWMCDFADDCGDASDEN-----EAVCKGRYR-- 3911
                 |.:..|:|           |.| |:... .|.....||..:..|     |..|...:.
Human  2139 NGVCVNTDGSFRCECPFGYSLDFTGIN-CVDTD-ECSVGHPCGQGTCTNVIGGFECACADGFEPG 2201

  Fly  3912 ---------ECSES----EFRCGNGK----CI--------SSRWQCDHEDDCGDNSDEMHCEGYQ 3951
                     |||.:    .|||.|.:    |.        .....|...|:|.|...:.|..|.:
Human  2202 LMMTCEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDGAMCRDVDECADGQQDCHARGME 2266

  Fly  3952 CKN--GTFQ-----------------------------CASGHCI--ASYFRCDGDRD------- 3976
            |||  |||.                             |.:|.|:  |..||||.|..
Human  2267 CKNLIGTFACVCPPGMRPLPGSGEGCTDDNECHAQPDLCVNGRCVNTAGSFRCDCDEGFQPSPTL 2331

  Fly  3977 -------------------CRDMSDEVGCPPRFP----GGR-------YCPESRFQCNNNLCVSL 4011
                               ||.:|.......|..    |||       .||.........||.
Human  2332 TECHDIRQGPCFAEVLQTMCRSLSSSSEAVTRAECCCGGGRGWGPRCELCPLPGTSAYRKLCP-- 2394

  Fly  4012 SDLCDGTDDCGDGSDED-----PSVCSDFNC-DTLRRFQCSNERCVARY------QICDGVDNCG 4064
                .|:....:|.|.|     ..:|:...| ::|..|:|   .|.|.|      ..|..:|.|.
Human  2395 ----HGSGYTAEGRDVDECRMLAHLCAHGECINSLGSFRC---HCQAGYTPDATATTCLDMDECS 2452

  Fly  4065 -----------------------------DGSDENNMTLCASKQKPCDLYTQYQCANK------H 4094
                                         ||....::..|.|:|..|    |:.|.|.      .
Human  2453 QVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRTCKDLDECTSRQHNC----QFLCVNTVGAFTCR 2513

  Fly  4095 C----IERSQVCDFSDDCGDASDELGCHHTSSCSEANRGGCQQHCHNLTDGGYICTCYPGYIIAA 4155
            |    .:..|.|..:|:|.......|.|              .|||| |.|.:.|.|:.|:.:.:
Human  2514 CPPGFTQHHQACFDNDECSAQPGPCGAH--------------GHCHN-TPGSFRCECHQGFTLVS 2563

  Fly  4156 DNKKKCSDVDECLTRQHTCSHQCHNLNGTYSCSCREGF 4193
            .. ..|.||:|| ...|.|.|.|.|..|.|.|||.:||
Human  2564 SG-HGCEDVNEC-DGPHRCQHGCQNQLGGYRCSCPQGF 2599

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.