DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and si:dkey-88l16.3

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:XP_021335179.1 Gene:si:dkey-88l16.3 / 796880 ZFINID:ZDB-GENE-030131-6015 Length:2335 Species:Danio rerio


Alignment Length:2036 Identity:578/2036 - (28%)
Similarity:799/2036 - (39%) Gaps:567/2036 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly  2801 KAECKCDDSTKVVNEGRMCAPRN-------------------NTCEASKFYCKNGR-CISRMWSC 2845
            |...||...:|..|:||.|...:                   |.|:|.:|.|.:|| ||.:...|
Zfish    12 KVPLKCRVGSKPCNDGRQCVLHDHVCDGEKDCKDGSDERGCPNRCKADQFRCAHGRMCIDKKQVC 76

  Fly  2846 DGDDDCGDNSDEDPNYCAYHSCSPNEFRCNN-GRCIFKSWKCDHENDCKDGSDELGC-------- 2901
            ||...|.|.|||...:...|.|   ..:|:| .|||.:|:.||.|.||.|.:||..|        
Zfish    77 DGTPQCQDRSDELNCFTRSHDC---RHQCDNKTRCIPESFLCDGERDCVDATDEANCSEIKGEED 138

  Fly  2902 -----------VYPP---CVDGEFTC-ANGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCP 2951
                       :.||   |......| ....||.|.|:|:|..||.|.  |||.  .| ::....
Zfish   139 KSVTPNKDTSGLQPPPPVCRSPSRLCPVTSLCITQTQICDGRIDCPDG--SDEV--SC-IDVCSK 198

  Fly  2952 ANHLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCG---------QRTCPTNSFRCPNHR-CIP 3006
            ..|..|:....|:|...:|||.:||.|:|||  |.|.         ...|...|..|.:.| |:|
Zfish   199 PGHFLCKDRRKCIEGNLVCDGHSDCLDDSDE--LDCSIPAKTTTRPALACRVGSKPCKDGRGCVP 261

  Fly  3007 ATWYCDGDDDCGDGADEPPDYCKSEGRTCFGDLFTC-DNGNCIPRIYICDGDNDCLDNSDEDNRH 3070
            .:..||||:||.||:||  :.|   |..|....|.| ..|.||....:|||...|||||||..  
Zfish   262 QSHLCDGDEDCKDGSDE--EDC---GHQCQEGQFQCVSGGRCIKMNQVCDGTPQCLDNSDEAG-- 319

  Fly  3071 QCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQP----CGED 3131
             |  ||........|    .|.. .|:|:.:||:|..||.||.||:    |||..:|    |...
Zfish   320 -C--RKPSRSCSLRC----DWDH-HCVPEAFICNGIRDCRDGTDED----NCAASRPDQTSCESP 372

  Fly  3132 MFTCGN-GRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQ-EFTCQN-FKCIRNQSRCDGED 3193
            ...|.: ..|:::..:||...||.||:||.    |....|:.. :|.|:: .|||.....|||:.
Zfish   373 SVLCPDMSVCVSQAQLCDGRRDCPDGSDEA----SCLDACAVPGDFLCEDRRKCIAEALVCDGQS 433

  Fly  3194 DCGDHSDEVGCAKENIT---CPQGQFACTNG-QCIDYNLVCNKYPDCADESDEPAHCNVDECAKV 3254
            .|.|.|||||| |..:|   |..|...|.|| :|:.||.:|:...||.|.|||      ::|   
Zfish   434 HCFDGSDEVGC-KTKMTPFKCRVGSKPCKNGRECVRYNHLCDGDRDCRDGSDE------EDC--- 488

  Fly  3255 EIN------QC--GHKCVDTLTGYYCDCNEGYKLLADG-KACAD-VDE--CLEQPGACSQHC-SN 3306
            |:.      ||  |.||:|            ::.:.|| ..|.| .||  |.:....||..| .|
Zfish   489 ELQCDPGMFQCIQGKKCID------------FRQVCDGTPQCPDHSDEANCWKPTKTCSIRCDGN 541

  Fly  3307 T---PGGFYCK--------CDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNLM 3360
            |   |..|.|.        .||...........||     .|:           ::..|....::
Zfish   542 TRCIPEVFVCNGMRDCWDGADEADCAMPTPPSPCK-----SPY-----------VACQGTSLCIL 590

  Fly  3361 HQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAIDWVG 3425
            .|                 |.||      .|....:..||.|..|....|.|             
Zfish   591 KQ-----------------YLCD------GRKDCPDGSDERPCLRNCPYRSD------------- 619

  Fly  3426 RKLYWLDRHSKNLDVSEL-DG--------------------SKRKTLRSGV-----VDPRAIVVH 3464
               :.....:|.:|..:: ||                    :.:.:||..|     .|.|..|:|
Zfish   620 ---FMCKDRTKCIDRKQVCDGRFHCIDHSDEIGCATTAPTTTTKASLRCRVGSKPCRDGRECVLH 681

  Fly  3465 PGIGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYA 3529
            ..:                  .||.:     :..||   .:.:..|:..:...:..||......|
Zfish   682 SHV------------------CDGES-----DCKDG---SDEIDCDFNCEAGQFQCAHGRKCIDA 720

  Fly  3530 DL--EGRHRHTVLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDL 3592
            .|  :|:.:....|..|                                ..:|..::.:||    
Zfish   721 KLVCDGKPQCQDFSDEK--------------------------------DCFTRSKSCSHR---- 749

  Fly  3593 HINHPLRQLPYTNPC--------GTNNGGCSH------------LC---LIAPPPESTYLN---- 3630
             .::..|.:|....|        ||:...|.:            ||   |:..||.|....    
Zfish   750 -CDNKTRCIPENFLCDGETDCVDGTDESDCGYPTKVVKCESPSVLCRDGLLCVPPTSLCDGKKDC 813

  Fly  3631 IEGYIEEGAPIFKC--ACPNQ-FYLARDMKTCVAN---CTAGQHLCGGRDE-------------- 3675
            .:||.|.     .|  .|||. .:|.:|.:.||..   |....|...|.||              
Zfish   814 PDGYDET-----FCFDRCPNSGDFLCKDRRKCVDKDLVCDGRSHCTDGSDEHGCPTKAAENSNSG 873

  Fly  3676 ---------------KCIPWFWKCDGEKDCKDGSDEPATCAPRHCRAGTFQCKNTN-CTPSATIC 3724
                           :|:.....|||||||.|||||..  .|..|:|..|:|.:.. |.....:|
Zfish   874 PLKCRVGSKPCNDGRQCVLHTHVCDGEKDCDDGSDEQG--CPNRCKADQFRCAHGRMCIDKKQVC 936

  Fly  3725 DGVDDCGDRSDEQNCDLPCPLSDFKCKSSGRCILDSWRCDGDADCKDGSDED--PAVCFKRTCDP 3787
            ||...|.|||||.||.........:|.:..|||.:|:.|||:.||.|.:||.  |::......||
Zfish   937 DGTPQCQDRSDELNCFTRSHDCKHQCDNKTRCIPESFLCDGEKDCVDATDEANCPSIPDASNADP 1001

  Fly  3788 KTEFSCKN--------GRCIPQLWMCDFDNDC--GDD--------SDEPAYMCR-QRNCT----- 3828
            .....|::        .:|:|:..:||...||  |.|        ||...::|: :|.|.     
Zfish  1002 LKTLGCRSPSMFCKETSKCMPESQLCDGKVDCPSGADEQFCIYSCSDPDHFLCKDKRKCVHKAVV 1066

  Fly  3829 -TGWQRC-PGQSNYR-------------CIPKWLFCDGKDDCRDNSDE-------------LPEN 3865
             .|:..| .|...|:             |:.|...||||.||||.|||             ||..
Zfish  1067 CDGYSHCADGSDEYQCPTCALQCDQKTVCLTKQQRCDGKPDCRDGSDEKDCYTGGVIASTSLPLR 1131

  Fly  3866 CP-----------------KCNPETD------------------FKCGNNR-CIPKQWMCDFADD 3894
            ||                 .|:.|.|                  |:|.:.| ||..:::||....
Zfish  1132 CPLGSKPCMDGKECVLLDHLCDGEKDCKDGSDERTCERKCKKGQFQCSHGRKCIDMKFVCDGTPQ 1196

  Fly  3895 CGDASDENEAVCKGRYRECSESEFRCGN-GKCISSRWQCDHEDDCGDNSDEMHCEGYQCKNGTFQ 3958
            |.|.||  ||.|.....||   ..:|.| .:|:...:.||.|.||.|.:||.:|....|....||
Zfish  1197 CQDRSD--EANCMKLSDEC---RHQCDNKTRCVPETFLCDGEKDCVDGTDEANCVVEPCSGDRFQ 1256

  Fly  3959 CASGHCIASYFRCDGDRDCRDMSDEVGC--PPRFPGGRYCPESRFQCNNNLCVSLSDLCDGTDDC 4021
            |::|.|:|...||||..||||.:||.||  ||..|....||      :.:.|:....||||..||
Zfish  1257 CSNGQCVALSLRCDGYADCRDHTDEKGCPQPPHCPLDHRCP------HTHECLLKEWLCDGDKDC 1315

  Fly  4022 GDGSDE-----DPSVCSDFNCDTLRRFQC-SNERCVARYQICDGVDNCGDGSDENNMTLCASKQK 4080
            .|||||     .|..|.:|      ::.| |..:|:|:...|||:.:|.|.|||:.   |...:.
Zfish  1316 SDGSDERNCKATPLKCGEF------QWSCASRTQCIAKTWRCDGMKDCQDESDESG---CGQTKC 1371

  Fly  4081 PCDLYTQYQCANKHCIERSQVCDFSDDCGDASDE-LGCHHTSSCSEANRGGCQQHCHNLTDGG-- 4142
            |..|   :||.:..|::...||:.:.||.|.||| :|| ..::||......||.:|.|...|.  
Zfish  1372 PTHL---FQCGSGECMDPDLVCNKASDCADGSDEGVGC-LKNNCSSPGSPSCQHYCINTPHGAVK 1432

  Fly  4143 -----YI--------------CTCYPGYIIAADNKKKCSDVDECLTRQ-HTCSHQCHNLNGTYSC 4187
                 ||              |.|..|:.:.:|. ..|.|:|||...| ..|||:|.|..|:|.|
Zfish  1433 HLFKFYISQLHVQKCCLCFQRCGCKTGFKLHSDG-LSCVDIDECKEIQPAACSHKCFNRLGSYIC 1496

  Fly  4188 SCREGFHL-TDGASGVCRAEKEDVILLFVNGQEIR-GLNWHKSEEFAVIAA--EKRIEALDYDAQ 4248
            .|...|.| .||.|  |:...|..:|:....:.:. ||   :|.....:.|  .|.|.:||||.:
Zfish  1497 QCHPEFLLEPDGHS--CKTADEPSLLVSEQDELLNMGL---RSFSIQTLTAPGRKPIFSLDYDLR 1556

  Fly  4249 QQIVFWADSYDKTIKRSYMVNAIDGRAKIGFAQDLNMKG----GSKPTAVAVDWLASNLYWTE-- 4307
            ::.|:||...|::|             |..|..:.:..|    |.|...:|:||:..||||.:  
Zfish  1557 ERRVYWASLEDESI-------------KYAFHGEKDNTGTIVKGVKSDCIAIDWMGRNLYWVDGV 1608

  Fly  4308 --------MDRTGSKPRGRVMVAKTDGRYRRSIVNAGLEVPTSIAVNPQLGRIYWSDAGSAPKIE 4364
                    :..:...|:..|:|...|           |:.|.|:.:.||.|.:.||..|...:|.
Zfish  1609 AGQILAVRLTNSVVHPQNYVVVLDED-----------LKQPNSLVLLPQKGIMLWSQVGGQAQIG 1662

  Fly  4365 VSWMDGSKRRPLITEMIRHPAGLTIDYSQDHIIYWVDTKLNAIESMRADGSRRKAIVRGDQLRH- 4428
            .|.||||.||.:|...:..|..:|:|...|. :||.|.||..|.|...||..    :|..||.| 
Zfish  1663 RSSMDGSDRRAVIRRGLNWPVSVTVDILTDR-LYWTDKKLGCIGSATLDGEN----IRFLQLSHM 1722

  Fly  4429 --PVSLDLFESNMFWMTRDTGELVRQDKF-GRGVQVVLHRYIVNPSGLKVYHDKRYNTSLPNPCD 4490
              |:|:.:|...::|.......:...:|. |:..:|.|.| ...|..|||.|..: ..::||||.
Zfish  1723 PSPLSMAVFNDMIYWSDTQRRSVQGANKLTGKNRKVFLKR-PGQPFALKVVHPLQ-QPNVPNPCQ 1785

  Fly  4491 NSTCSHLCLLVPGGHR-CACP 4510
            :..|||:|||.||... |.||
Zfish  1786 SLHCSHVCLLAPGLKAVCRCP 1806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1728 CDD:278487
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060 15/34 (44%)
LDLa 2906..2941 CDD:238060 14/35 (40%)
LDLa 2950..2983 CDD:238060 12/32 (38%)
LDLa 3034..3066 CDD:197566 14/32 (44%)
LDLa 3080..3115 CDD:197566 11/34 (32%)
LDLa 3128..3159 CDD:238060 9/31 (29%)
LDLa 3170..3204 CDD:238060 15/35 (43%)
LDLa 3210..3242 CDD:197566 14/35 (40%)
cEGF 3269..3292 CDD:289433 4/24 (17%)
vWFA <3284..3324 CDD:294047 16/55 (29%)
LY 3362..3394 CDD:214531 5/31 (16%)
LY 3406..3448 CDD:214531 6/62 (10%)
LY 3498..3536 CDD:214531 8/39 (21%)
LY 3536..3578 CDD:214531 2/41 (5%)
FXa_inhibition 3607..3659 CDD:291342 19/81 (23%)
LDLa 3663..3696 CDD:238060 16/61 (26%)
LDLa 3705..3739 CDD:238060 14/34 (41%)
LDLa 3743..3775 CDD:197566 11/31 (35%)
LDLa 3784..3817 CDD:197566 12/50 (24%)
LDLa 3827..3861 CDD:197566 16/53 (30%)
LDLa 3871..3901 CDD:197566 12/48 (25%)
LDLa 3913..3947 CDD:238060 12/34 (35%)
LDLa 3952..3986 CDD:238060 17/33 (52%)
LDLa 3996..4027 CDD:197566 12/30 (40%)
LDLa 4043..4071 CDD:238060 12/28 (43%)
LDLa 4086..4117 CDD:238060 11/31 (35%)
EGF_CA 4163..4194 CDD:214542 14/31 (45%)
NHL 4276..>4426 CDD:302697 48/163 (29%)
NHL repeat 4291..4336 CDD:271320 11/54 (20%)
Ldl_recept_b 4350..4390 CDD:278487 15/39 (38%)
NHL repeat 4376..4422 CDD:271320 14/45 (31%)
si:dkey-88l16.3XP_021335179.1 LDLa 17..52 CDD:238060 6/34 (18%)
LDLa 56..91 CDD:238060 16/34 (47%)
LDLa 100..130 CDD:238060 14/29 (48%)
LDLa <170..192 CDD:238060 12/25 (48%)
LDLa 199..232 CDD:238060 14/34 (41%)
LDLa 246..281 CDD:238060 16/36 (44%)
LDLa 285..320 CDD:238060 16/37 (43%)
LDLa <334..359 CDD:238060 11/29 (38%)
LDLa 369..404 CDD:238060 11/38 (29%)
LDLa 411..444 CDD:238060 14/32 (44%)
LDLa 453..488 CDD:238060 15/40 (38%)
LDLa 492..527 CDD:238060 12/46 (26%)
LDLa 575..610 CDD:238060 11/73 (15%)
LDLa 620..650 CDD:238060 4/29 (14%)
LDLa 665..700 CDD:238060 9/60 (15%)
LDLa 704..739 CDD:238060 7/66 (11%)
LDLa 748..778 CDD:238060 7/34 (21%)
LDLa 787..822 CDD:238060 9/39 (23%)
LDLa 829..862 CDD:238060 9/32 (28%)
LDLa 877..912 CDD:238060 13/36 (36%)
LDLa 916..951 CDD:238060 14/34 (41%)
LDLa 959..990 CDD:238060 13/30 (43%)
LDLa 1048..1082 CDD:238060 8/33 (24%)
LDLa <1095..1117 CDD:238060 13/21 (62%)
LDLa 1132..1167 CDD:238060 5/34 (15%)
LDLa 1171..1206 CDD:238060 13/36 (36%)
LDLa 1215..1245 CDD:238060 11/29 (38%)
LDLa 1250..1284 CDD:238060 17/33 (52%)
LDLa 1290..1324 CDD:238060 15/39 (38%)
LDLa 1331..1366 CDD:238060 14/43 (33%)
LDLa 1371..1402 CDD:238060 11/33 (33%)
cEGF 1453..1474 CDD:315355 6/21 (29%)
EGF_CA 1471..1512 CDD:214542 19/42 (45%)
LY <1593..1620 CDD:214531 7/26 (27%)
Ldl_recept_b 1650..1688 CDD:278487 14/37 (38%)
LY 1672..1713 CDD:214531 15/41 (37%)
LY 1721..1756 CDD:214531 7/34 (21%)
LY <2004..2036 CDD:214531
FXa_inhibition 2105..2139 CDD:317114
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - O PTHR22722
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.910

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