DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mgl and vldlr

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:XP_002934223.1 Gene:vldlr / 733485 XenbaseID:XB-GENE-971958 Length:868 Species:Xenopus tropicalis


Alignment Length:901 Identity:318/901 - (35%)
Similarity:431/901 - (47%) Gaps:186/901 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly  2826 CEASKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFKSWKCDHEN 2890
            ||.|:|.|.||.||:.:|.||||:||.|.|||  :.|...:|:..:|.||||.|:.:.|:||.:.
 Frog    31 CEGSQFQCANGHCITSLWKCDGDEDCSDGSDE--SSCVKKTCAETDFVCNNGLCVPRRWECDGDP 93

  Fly  2891 DCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPANHL 2955
            ||:||                                         ||||.|.|.|.|       
 Frog    94 DCEDG-----------------------------------------SDETAELCHMRT------- 110

  Fly  2956 KCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYCDGDDDCGDG 3020
             |..|.|                       .||.|:.          :|||.:|.|||:.||.:.
 Frog   111 -CRATEI-----------------------SCGARST----------QCIPLSWKCDGESDCPNA 141

  Fly  3021 ADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNRHQCNDRKCDEETEFTC 3085
            .||  :.|.:  .||....|||.:|.||...::|:|.|||.|.|||:|   |....|... ||.|
 Frog   142 EDE--ENCGN--ITCSPAEFTCSSGRCISSTFVCNGQNDCSDGSDEEN---CVPPTCGAH-EFQC 198

  Fly  3086 VENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQ----QPCGEDMFTCGNGRCINKGWI 3146
                  :.:.|||..|:||.|.||.|.:||  :|..|..|    |.|..:...||:|.||:|.|.
 Frog   199 ------KNSSCIPLNWVCDDDSDCADHSDE--SLEQCGRQPIAPQKCSANEMPCGSGECIHKKWR 255

  Fly  3147 CDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRNQSRCDGEDDCGDHSDEVGCAKENITC 3211
            ||.|.||.|.:||   .|...:||...:|.|::..||....:|||..||.|.:||:.|...|...
 Frog   256 CDGDPDCKDKSDE---MNCPSRTCQPDQFKCEDGNCIHGSRQCDGVRDCLDGTDEIRCKNVNQCS 317

  Fly  3212 PQGQFACTNGQCIDYNLVCNKYPDCADESDEP-AHCNVDECAKVEINQ--CGHKCVDTLTGYYCD 3273
            ..|:|.|.:|:|||...||||..||.|.|||| ..|.|:||   |:|.  |.|.|.:.:.||.||
 Frog   318 GPGKFKCRSGECIDIAKVCNKQKDCKDWSDEPIKECYVNEC---EVNNGGCSHLCHNLVIGYECD 379

  Fly  3274 CNEGYKLLADGKACADVDECLEQPGACSQHCSNTPGGFYCKCDETYYERQNDEHT--CKRKDKIP 3336
            |..|:||: |.|.|.|:||| :.|..|||.|.|..||:.|:|.:.|   |.|..|  ||...: .
 Frog   380 CTAGFKLI-DRKTCGDIDEC-QNPEICSQICVNLKGGYKCECSKGY---QMDPSTGVCKAVGR-E 438

  Fly  3337 PWLIFTNKYYVRNMSVDGHQYNLMHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEM 3401
            |.|||||:..:|.:.::..:|..:.:.|.|.||||.||:|:.:::.|...|.||||.:       
 Frog   439 PCLIFTNRRDIRKVGLERKEYIQLVEQLRNTVALDADIKEQSLFWADTIQKAIFRAPF------- 496

  Fly  3402 PPEREAVIRH-----DSHGLEGIAIDWVGRKLYWLDRHSKNLDVSELDGSKRKTL-RSGVVDPRA 3460
             ..||.|..|     |.|....|||||:.:.:||:|...|.:.||..|||||||| .||:.||.:
 Frog   497 -DTREKVGTHIKVVEDVHSPSAIAIDWIYKNIYWMDTGLKTISVSNFDGSKRKTLFNSGLQDPTS 560

  Fly  3461 IVVHPGIGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDY 3525
            |.|.|..|::|::.|...|.|.|.||:|.:..:.:..:  :..|:.::||....|:||.|:.|..
 Frog   561 IAVDPISGFIYWSDWGEPAKIEKAGMNGIDRQQFVTAD--VQRPSGIAIDVVKSRLYWVDSKLHT 623

  Fly  3526 IAYADLEGRHRHTVLSGSK-VPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRP 3589
            ::..||.|..|..:|...: :.|..||::|:|.:||.|...:||..||||.|.....|.|..:..
 Frog   624 LSSVDLNGLDRRVILKSHEFLAHPLALTIFEDRVYWIDGENEAIYGANKFSGQELETLVNNLNEA 688

  Fly  3590 YDLHINHPLRQLPYTNPCGTN-------NGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACP 3647
            .|:.:.|.|.|     |.|.|       ||||.:|||.||           .|.:.:|.:.|.||
 Frog   689 QDVIVYHELVQ-----PLGRNWCNEQIENGGCKYLCLPAP-----------QISDNSPKYTCVCP 737

  Fly  3648 NQFYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAPR 3703
            :.|                 .|.|||  .|.|      |.|...|.:.:|....|:
 Frog   738 DGF-----------------ELNGGR--SCRP------GSKATMDHTVKPTGILPK 768

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1728 CDD:278487
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060 14/33 (42%)
LDLa 2906..2941 CDD:238060 3/34 (9%)
LDLa 2950..2983 CDD:238060 3/32 (9%)
LDLa 3034..3066 CDD:197566 15/31 (48%)
LDLa 3080..3115 CDD:197566 13/34 (38%)
LDLa 3128..3159 CDD:238060 14/30 (47%)
LDLa 3170..3204 CDD:238060 13/33 (39%)
LDLa 3210..3242 CDD:197566 15/31 (48%)
cEGF 3269..3292 CDD:289433 12/22 (55%)
vWFA <3284..3324 CDD:294047 17/39 (44%)
LY 3362..3394 CDD:214531 15/31 (48%)
LY 3406..3448 CDD:214531 19/46 (41%)
LY 3498..3536 CDD:214531 11/37 (30%)
LY 3536..3578 CDD:214531 17/42 (40%)
FXa_inhibition 3607..3659 CDD:291342 17/58 (29%)
LDLa 3663..3696 CDD:238060 9/32 (28%)
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
vldlrXP_002934223.1 LDLa 31..65 CDD:238060 20/35 (57%)
Ldl_recept_a 68..101 CDD:365841 15/73 (21%)
Ldl_recept_a 109..147 CDD:365841 18/80 (23%)
Ldl_recept_a 151..186 CDD:365841 18/37 (49%)
LDLa 190..222 CDD:197566 14/38 (37%)
Ldl_recept_a 236..271 CDD:365841 16/37 (43%)
Ldl_recept_a 274..310 CDD:365841 14/35 (40%)
LDLa 316..348 CDD:197566 15/31 (48%)
FXa_inhibition 358..392 CDD:373209 16/37 (43%)
EGF_CA 394..424 CDD:214542 15/33 (45%)
LY 505..547 CDD:214531 17/41 (41%)
LY 548..591 CDD:214531 19/42 (45%)
LY 592..634 CDD:214531 11/43 (26%)
Ldl_recept_b 655..694 CDD:393440 14/38 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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