Protein Alignment mgl and si:dkey-258f14.3

DIOPT Version :10

• Sequence 1: NP_572563.3
• Gene: mgl / 8674055
• FlyBaseID: FBgn0261260
• Length: 4769
• Species: Drosophila melanogaster
• Sequence 2: XP_021334056.3
• Gene: si:dkey-258f14.3 / 571152
• ZFINID: ZDB-GENE-050809-43
• Length: 526
• Species: Danio rerio
• Alignment Length: 619
• Identity: 170/619 - (27%)
• Similarity: 248/619 - (40%)
• Gaps: 170/619 - (27%)

  Fly  1228 CGTSQFACANGRCIPNMWKCDSENDCGDSSDEGDFCAEKTCAYFQFTCPRTGHCIPQSWVCDGDD 1292
            |...||.|||.||:....:||:.|||||.|||             .:|          |
Zfish    38 CTVLQFVCANSRCVSLSSRCDAVNDCGDGSDE-------------ISC----------W------ 73

  Fly  1293 DCFDKQDEKDCPPISCLANQFKCADLRQCVEESYKCDGIPDCNDGSDEV--GCPSMGPNQCNLEK 1355
                          :|....|.|.....||..|..|||.|||.||:||.  .|.|....|.....
Zfish    74 --------------NCTNGSFHCVASESCVSSSSVCDGRPDCADGADEQLDTCTSFSQAQPCARS 124

  Fly  1356 HFRCKSTGFCIPIAWHCDGSNDCSDHSDEQDCGQITCAQNFFKCNNTNCVFKAYICDGKDDCGDN 1420
            .|.| :.|.|:|.:|.||.|:||.|.|||:||....||.|
Zfish   125 EFTC-TNGQCVPNSWRCDHSSDCKDGSDEEDCDHNECAVN------------------------- 163

  Fly  1421 SDEGAEHACVPPPFKCPHGQWQCPGVSERCVNITSVCDDTPDCPNGSDEGEGCDLAECEHQAGQC 1485
             :.|..|.|:..||
Zfish   164 -NGGCSHTCIDLPF--------------------------------------------------- 176

  Fly  1486 SSFCQKTPNGALCVCPPGSEIGEDGY-----TCIDSNECDPPGLCSQQCTNTKGSYFCSCTDGYV 1545
                     |..|.||.|..:.:|.:     .|:|::.||      |.|.::.||..|.|.|||.
Zfish   177 ---------GFRCDCPKGMRLVQDTHCEVVDQCLDADVCD------QICVHSNGSVVCDCQDGYQ 226

  Fly  1546 LEPNKHTCKAVNHTAAFLIISNRHSILVADLK--------EQGLERVPIIVENVVATASNMHTGT 1602
            |......|:|.. ..|.:.:|.:..|.:.||.        ::.|...|:       :|.|.| .|
Zfish   227 LTAGTGQCRATG-GLAHVAVSTQEGIKMMDLSGSEERNITDKRLSPGPV-------SALNAH-NT 282

  Fly  1603 IFWSDMKLKKISR--LDRG-MEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEV-SAENGS 1663
            ::||..:...|.|  ||.| ..|...:.....:| |||.|||.::|||:.:....:.: |.:|..
Zfish   283 LYWSSPENDIIYRMSLDSGDHRPAVWLKASKGIV-GLAVDWIHESLYWISTSTRALHMASLKNTK 346

  Fly  1664 NRLVLVRENITQPRGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLD 1728
            .||::  ..:::|..:.:.|..|  ::||.:.||:.|:||:|:||..|..::.:.:..|..::||
Zfish   347 QRLLI--SGLSKPTAVAVQPLLG--YVFWAEGGESARIERVGLDGESRFALVVSFVRNPVAISLD 407

  Fly  1729 IATKRVYFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKF 1793
            |....:|:|||.|..|....::|..|:.|:.|:.||..|..|::||..:||:|:..|.:.||:|.
Zfish   408 IPRGLLYWADSGLRSISRVLFDGQYRKTVVESNGYLDQPFGLAIFESRVYWSDQLTNSICSADKH 472

  Fly  1794 RGKNQTVVSHLIS-QPLSIHVHHASLQPMTPNPC 1826
            .|....|...|.| .|..:.:.|..|||.....|
Zfish   473 NGTMLRVPQRLGSASPAGLVILHPLLQPAAALSC 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mgl	NP_572563.3	LDLa	157..189	CDD:238060
		LDLa	204..236	CDD:238060
		LDLa	292..327	CDD:238060
		LDLa	332..366	CDD:238060
		LDLa	371..412	CDD:238060
		vWFA	<447..488	CDD:469594
		YncE	<492..634	CDD:442618
		NHL	573..>716	CDD:302697
		NHL repeat	573..610	CDD:271320
		NHL repeat	616..654	CDD:271320
		NHL repeat	657..693	CDD:271320
		FXa_inhibition	763..805	CDD:464251
		YvrE	854..>992	CDD:442613
		LY	922..964	CDD:214531
		LY	973..1007	CDD:214531
		Ldl_recept_a	1188..1223	CDD:395011
		LDLa	1227..1259	CDD:197566	16/30 (53%)
		LDLa	1268..1303	CDD:238060	2/34 (6%)
		LDLa	1308..1343	CDD:238060	16/36 (44%)
		LDLa	1356..1387	CDD:238060	15/30 (50%)
		LDLa	1391..1423	CDD:197566	3/31 (10%)
		LDLa	1435..1469	CDD:197566	0/33 (0%)
		FXa_inhibition	1522..1553	CDD:464251	10/30 (33%)
		LY	1625..1665	CDD:214531	12/40 (30%)
		LY	1667..1711	CDD:214531	13/43 (30%)
		Ldl_recept_b	1690..1729	CDD:459654	13/38 (34%)
		LY	1712..1754	CDD:214531	11/41 (27%)
		LY	1986..2037	CDD:214531
		FXa_inhibition	2151..>2179	CDD:464251
		LY	2259..2305	CDD:214531
		Ldl_recept_b	2326..2366	CDD:459654
		LY	2352..2392	CDD:214531
		NHL	2579..>2711	CDD:302697
		NHL repeat	2593..2622	CDD:271320
		NHL repeat	2634..2678	CDD:271320
		LY	2671..2713	CDD:214531
		LDLa	2867..2901	CDD:238060
		LDLa	2906..2941	CDD:238060
		LDLa	2950..2983	CDD:238060
		LDLa	3034..3066	CDD:197566
		LDLa	3080..3115	CDD:197566
		LDLa	3128..3159	CDD:238060
		LDLa	3170..3204	CDD:238060
		LDLa	3210..3242	CDD:197566
		FXa_inhibition	3259..3287	CDD:464251
		FXa_inhibition	3293..3329	CDD:464251
		LY	3362..3394	CDD:214531
		LY	3406..3448	CDD:214531
		Ldl_recept_b	3468..3511	CDD:459654
		LY	3498..3536	CDD:214531
		LY	3536..3578	CDD:214531
		FXa_inhibition	3607..3659	CDD:464251
		LDLa	3663..3696	CDD:238060
		LDLa	3705..3739	CDD:238060
		LDLa	3743..3775	CDD:197566
		LDLa	3784..3817	CDD:197566
		LDLa	3827..3861	CDD:197566
		LDLa	3871..3901	CDD:197566
		LDLa	3913..3947	CDD:238060
		LDLa	3952..3986	CDD:238060
		LDLa	3996..4027	CDD:197566
		LDLa	4043..4071	CDD:238060
		LDLa	4086..4117	CDD:238060
		EGF_CA	4163..4194	CDD:214542
NHL	4276..>4426	CDD:302697
NHL repeat	4291..4336	CDD:271320
Ldl_recept_b	4350..4391	CDD:459654
LY	4374..4417	CDD:214531
NHL repeat	4376..4422	CDD:271320
si:dkey-258f14.3	XP_021334056.3	None