DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and lrp5

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:XP_009296098.1 Gene:lrp5 / 568518 ZFINID:ZDB-GENE-050518-2 Length:1615 Species:Danio rerio


Alignment Length:1435 Identity:448/1435 - (31%)
Similarity:710/1435 - (49%) Gaps:150/1435 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly  1563 LIISNRHSILVADLKEQGLERVPIIV---ENVVATASNMHTGTIFWSDMKLKKISR--------- 1615
            |:.:||..:.:.|: |.|.....::|   |:..|.......|.|||:|:..:.|.:         
Zfish    32 LLFANRRDVRLVDV-EVGRSESAVVVSDLEDAAAVDFLFSEGLIFWTDVSEEAIKQTYYNLSTNS 95

  Fly  1616 -----LDRGMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQ 1675
                 |.:|   |.::.:|||..:|||.||:...|||.||:.|.|||:..:|::|.||..:::.|
Zfish    96 MKEATLGKG---QTVVVSGLDSPDGLACDWLGHKLYWTDSETNRIEVANLDGTSRKVLFWQDLDQ 157

  Fly  1676 PRGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRVYFADSK 1740
            ||.:.::||  .|:::||||||.||:||.||||:.|:.|:..:||||||||:|:..:::|:||:|
Zfish   158 PRAIALNPS--HRYMYWTDWGEEPRIERAGMDGSNRQIIVQKQIYWPNGLTIDLDEQKLYWADAK 220

  Fly  1741 LDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGKNQTVVSHLI 1805
            |.||.....:||.|:.|:..|  |.||.:|:|:::||||||.|...:.:.||..|:....:.:.|
Zfish   221 LSFIHRANLDGTSREAVVEGS--LTHPFALTLYDETLYWTDWQTRSIHACNKHSGEKHREILNGI 283

  Fly  1806 SQPLSIHVHHASLQPMTPNPCA--GSRCQHLCLLSPSAPEGYSCKCRPGFKLLSEGR-CIEEENP 1867
            ..|:.|.|.....||....||:  ...|.||||||| .|..|||.|..|.||..:|: |......
Zfish   284 YSPMDIQVLGQERQPNIQTPCSERNGGCSHLCLLSP-IPPFYSCACPTGVKLKEDGKTCRPGAEQ 347

  Fly  1868 FLMVVKGTQI----VDLPLNGGDARAGALAPVIGIESSTGLDFDRKGETLYWVQGREDDDENCTI 1928
            .|::.:.|.:    :|||     .....:..|..|..:..:|:|.....:||.     |||...|
Zfish   348 VLLLARRTDLRRISLDLP-----DFTDIVLQVNDIRHAIAIDYDPVEGYVYWT-----DDELRAI 402

  Fly  1929 YTTPYGGGNKTLFLGIENGIVGAPYTIAFDWLGRNLYIGNRVASNIEAVRVDGKQKYRTIILAND 1993
            ......|.:....:..|   :..|..||.||:.||||..:.....||..|::|..: |.:|..| 
Zfish   403 RRARIDGSDAQTLITNE---INHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR-RVLISEN- 462

  Fly  1994 GYPNSVSRPKQIALDPTEGKLFWIDEGVLEVPIKIGRVDMNGQNPIVVFQ-EFAHPESLAVDTEK 2057
                 :..|:.|.|||..|.::|.|.|  |:| ||.|.:::|.:.:|:.. ....|..||:|...
Zfish   463 -----LDEPRAIVLDPINGYMYWTDWG--ELP-KIERANLDGTDRVVLLNTSLGWPNGLAIDYIA 519

  Fly  2058 KMVYYSASNPAVIGVMDYNGDDHTLILMKDSHPMAKPRSLG--ILDHRLYYLDPLYERIVRIDLP 2120
            ..:|:..:....|.|::.:|.:...|| :|.    .|...|  :|...:|:.|.....|.|:.:.
Zfish   520 GKLYWGDAKTDKIEVINVDGTNRMTIL-EDK----LPHIFGFTLLGEYIYWTDWQRRSIERVHIA 579

  Fly  2121 HGDNPKTIVDNESDLRSMMIYKKRALMQ----HPCQTNNGGCKHLCIPGPGATRTCACGIGYRKE 2181
            :... :.||:...||..:   |...:|:    :.|..|||||.|||...|... :|||.:|....
Zfish   580 NSTR-EVIVEQLPDLMGL---KATKVMEAEGTNGCAENNGGCSHLCFHRPQGL-SCACPMGLELL 639

  Fly  2182 NEI-NCVAYKIFAVVSQLDMIRGYSL-SDSSEAMVPISGPGH-HILHVDVMYREQWIYWAEYNRG 2243
            ::: .||..:.|.:.:....||..|| ::|::..:|::|... ..|..||:  |..|||.:.:. 
Zfish   640 SDLRTCVVPEAFLLFTNRADIRSISLGTNSNDVPIPLTGVKEASALDFDVL--ENRIYWTDVST- 701

  Fly  2244 YWNGIFRSRPNGTDLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVL 2308
              ..|.|:..||:.::.|::.|:  :...|:.:||:..|:|:.:.  ..|.:||..|||..|:||
Zfish   702 --KTISRAFMNGSSVEPVIEFGL--DYPEGMAVDWMGRNLYWADT--GTNRIEVARLDGQYRQVL 760

  Fly  2309 VKTTTDAPRELAVNPIKRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHDIY 2373
            |....|.||.||::|....:||.::|..|||.:|.:|||....||.. :.....||||.....:|
Zfish   761 VCKDLDNPRSLALDPANGYMYWTEWGGRPRIARAHMDGSNIVTLVDK-VGRANGLTIDYIDQRLY 824

  Fly  2374 WVDSKLDT--IQKISYNGANRKIIRRDLPNPMGIAVYLNDVYWVDRNLMTVFKASKHSA-NETAT 2435
            |.|  |||  |:..:..|..|:|:..|||:|.|:..|.:.:||.|.||.::.:|.|.|. |.|. 
Zfish   825 WTD--LDTCMIESTNMQGLQREIVADDLPHPFGLTQYRDYIYWTDWNLRSIERADKRSGLNRTV- 886

  Fly  2436 SVRTNLEKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPPDGGASGTSGGRNFRCECATG 2500
             |:.:||.:.||.::  ::..||..|.|:. .||.|..||.:.|        ||.   :|.||:.
Zfish   887 -VQGHLEYVMDILVF--HSSRQDGANDCSQ-NNGQCAHLCLASP--------SGA---QCRCASH 936

  Fly  2501 -KLSADERKCEVVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNLTNVVGLDFDFAHNRMLYTQI 2564
             .|.|:.|.|...:.:|:|:.::.|..:.|...|.:: ..|:..:.|:..:.||           
Zfish   937 YTLEANGRNCSSPSSFLLFSQKSSISRMVLGEQSPDM-ILPIHVMKNLRAISFD----------- 989

  Fly  2565 RPWAKIAY--------TKANKPGHDDITVVLNKGINPE---GIAYDWTQQKIYWTDSSNNSIYAM 2618
             |..::.|        .::...|....||:.....:|:   .::.|...:.:|||..:.|:|...
Zfish   990 -PLERLVYWVDGRQNIRRSRDDGTQASTVMTPNSDHPKQPHDLSLDPYSRTVYWTCETTNTINIH 1053

  Fly  2619 NLDGSEL--VMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIVDKDLSQP 2681
            .:||..:  |:...|::|||||::...|.::||....  .|.||...::.|:.:.::....|.:|
Zfish  1054 RMDGHIIGEVLKDDVDKPRAIVVNAEKGYMYFTTVQE--RSAKIEGASLDGTERESLFTTSLIRP 1116

  Fly  2682 SGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATI-YPFAITVFRNYIYWTDLQLRGVYR 2745
            ..||:|....:|:|.||..::||.|||.|.||.:|..:.| .|..:||..:::||.|.|.:.:.|
Zfish  1117 VALALDNKLGKLFWVDADLKRIESSDLSGANRIVLQDSNILQPVGLTVLGDHLYWIDKQQQMIER 1181

  Fly  2746 AEKHTGANMVEMVKRLEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGKAECKCDDST 2810
            .:|.||.....:..||:.......:...:..:...:||..:||||:..|....:|...|.|....
Zfish  1182 VDKLTGEKRTRIQGRLQYLTGIHAVQYMETDEFATHPCSRDNGGCSHICIAKGDGTPRCSCPMHL 1246

  Fly  2811 KVVNEGRMCAPRNNTCEASKFYCKNGR--CISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFR 2873
            .::.....|. ...||.:.:|.|..|.  ||...|.|||..:|.|||||  ..|..  ||..:|:
Zfish  1247 VLLQNLLSCG-EPPTCSSEQFTCATGEIDCIPMAWRCDGIAECADNSDE--MNCPI--CSKLQFQ 1306

  Fly  2874 CNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATSD 2938
            |:.|:|:....:|:.|.||.|||||..| ...|:..:|.|.|.:||.:.|.|:...||     :|
Zfish  1307 CDKGQCVDIQVRCNGEPDCADGSDEQDC-ETICLSNQFRCGNSQCILKKQQCDSFPDC-----TD 1365

  Fly  2939 ETHER 2943
            |:.||
Zfish  1366 ESDER 1370

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531 18/39 (46%)
LY 1667..1711 CDD:214531 22/43 (51%)
Ldl_recept_b 1690..1728 CDD:278487 24/37 (65%)
LY 1712..1754 CDD:214531 19/41 (46%)
LY 1986..2037 CDD:214531 18/50 (36%)
FXa_inhibition 2151..>2179 CDD:291342 14/27 (52%)
LY 2259..2305 CDD:214531 13/45 (29%)
Ldl_recept_b 2326..2366 CDD:278487 14/39 (36%)
LY 2352..2392 CDD:214531 14/41 (34%)
NHL 2579..>2711 CDD:302697 40/136 (29%)
NHL repeat 2593..2622 CDD:271320 7/31 (23%)
NHL repeat 2634..2678 CDD:271320 12/43 (28%)
LY 2671..2713 CDD:214531 15/41 (37%)
LDLa 2867..2901 CDD:238060 15/33 (45%)
LDLa 2906..2941 CDD:238060 12/34 (35%)
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
cEGF 3269..3292 CDD:289433
vWFA <3284..3324 CDD:294047
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:291342
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
lrp5XP_009296098.1 LY 105..147 CDD:214531 19/41 (46%)
Ldl_recept_b 168..208 CDD:278487 25/39 (64%)
LY 192..234 CDD:214531 19/41 (46%)
LY 235..269 CDD:214531 14/35 (40%)
FXa_inhibition 304..341 CDD:291342 18/37 (49%)
Ldl_recept_b 390..429 CDD:278487 11/46 (24%)
LY 413..455 CDD:214531 14/44 (32%)
LY 456..499 CDD:214531 18/51 (35%)
LY 501..542 CDD:214531 9/40 (23%)
LY 544..583 CDD:214531 10/43 (23%)
FXa_inhibition 610..645 CDD:291342 14/35 (40%)
LY 674..714 CDD:214531 13/44 (30%)
LY 717..757 CDD:214531 13/43 (30%)
LY 758..800 CDD:214531 18/41 (44%)
LY 802..843 CDD:214531 14/43 (33%)
LY 845..884 CDD:214531 15/38 (39%)
FXa_inhibition 911..946 CDD:291342 15/46 (33%)
LY 974..1013 CDD:214531 7/50 (14%)
LY 1106..1148 CDD:214531 15/41 (37%)
FXa_inhibition 1219..1255 CDD:291342 9/35 (26%)
LDLa 1261..1297 CDD:238060 16/37 (43%)
LDLa 1300..1334 CDD:238060 15/33 (45%)
LDLa 1338..1372 CDD:238060 14/38 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.710

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