DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and LRP1B

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_061027.2 Gene:LRP1B / 53353 HGNCID:6693 Length:4599 Species:Homo sapiens


Alignment Length:4470 Identity:1566/4470 - (35%)
Similarity:2263/4470 - (50%) Gaps:457/4470 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   319 GDNSDEQGCNFPPCHHAQFRC-TNALCIPYNFHCDGYHDCADKSDEANCTA-----IACPDNKHL 377
            |.:.|:|.|:     ..:|.| .:..|:..::.|||..||.|.|||:..|.     |.||.|...
Human    24 GADRDQQLCD-----PGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIA 83

  Fly   378 CPRGGASGTPKCILKSQLCDGKRDCEDGSDEETNCS--IASCPALSCEFKCGPSLTGGVCYCKPG 440
            |     .||.||:..||||:|..||.||.||..:|.  :::|..|:|::||........|||:.|
Human    84 C-----LGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDG 143

  Fly   441 QSLAPDNRTCVDLDECAEWGHCDQLCTNTLGSYTCQCAQGYTLINDSK-C---IAPDANNLQLIF 501
            ..:..|.|:|.|.||||.:|.|.|.|.||.|||||.|.:||.:..|:: |   |.|......|:.
Human   144 FEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLI 208

  Fly   502 AHDRAIMRMLPHGSEPKILA--NATAAAGVTFHYARNTLYWSDIKTRKVQS-LPLDAQNKAVSPF 563
            |:...|.....:||:...|:  |......:.|.|..:.:.|  |::|:..: |......||....
Human   209 ANFETIEVFYLNGSKMATLSSVNGNEIHTLDFIYNEDMICW--IESRESSNQLKCIQITKAGGLT 271

  Fly   564 DQTLPGTWA---------PVALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADL 619
            |:     |.         ...:|:||:...:|..|.||.:|.|...:|.....::...|.:|..:
Human   272 DE-----WTINILQSFHNVQQMAIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAI 331

  Fly   620 ALDPTAGLMFVADGGQVL---RAHMDGTHARSIVSEAAYKASGVTVDIISKRVFWCDSLLDYIES 681
            |:||.||.:|..|.|.|.   |..|||.:...|:.....:.:.:.:|:::|.|:|.|..|||:..
Human   332 AVDPIAGKLFFTDYGNVAKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGV 396

  Fly   682 VDYEGAHRVMVLRGQQVPSPSRLALFENRIYWTDATKQGIMSVDKFEGPTSIQVTYKAKDIREPK 746
            |||:|.:|..|::|:||.....:.:||:.:|.|::....|:.:::|.| |.|....|   |....
Human   397 VDYQGKNRHTVIQGRQVRHLYGITVFEDYLYATNSDNYNIVRINRFNG-TDIHSLIK---IENAW 457

  Fly   747 GIIAVHALSQPRV-SNPCG----NNNGGCNHMCIVTAVKGAPTGLGFRCACSTGYQLETDLKLCK 806
            ||......:||.| |:.|.    ...|||:|:|::::.....|     |.|.||:.|.:|.:.||
Human   458 GIRIYQKRTQPTVRSHACEVDPYGMPGGCSHICLLSSSYKTRT-----CRCRTGFNLGSDGRSCK 517

  Fly   807 -PVSE-FLMYSQQR--FIKGKVLEPVIEGFSDAIMPV---VSRRARFVGLDFDARDEFIYYSDVL 864
             |.:| ||.|.:.|  .::|..|...|.  .:.::|:   |:.||    |||.|...:||::|..
Human   518 RPKNELFLFYGKGRPGIVRGMDLNTKIA--DEYMIPIENLVNPRA----LDFHAETNYIYFADTT 576

  Fly   865 QDVIYRVHRNGTGREIVLASQNEGVEGLAVDWASKNLYYI-DSRKGTLNVLSTRNVTH-RRTLLK 927
            ..:|.|...:||.||.:|....:.|||:||||...|||:. |..:.|:||......:. |:|||:
Human   577 SFLIGRQKIDGTERETILKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLE 641

  Fly   928 -NLKRPRAIVVHPNRGFIFFSEW------DRPANITRANTDGSGLLVFKNVTLGWPNGLSIDFKE 985
             .:..||.|||.|..|::::::|      |....|.:|..||....:|....:.|||||::||..
Human   642 GEMSHPRGIVVDPVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHT 706

  Fly   986 DRVYWCDALLDHVQHANLDGTDIKTVNS-RLVRHPFSIVIHNDWMYITDWRLDAIIRLHKLTGEQ 1049
            :.:|||||..||::...|:||..|.|.| |.:.|||.:..|.::::.||:...:|.:|..:|.|.
Human   707 NTLYWCDAYYDHIEKVFLNGTHRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLITSEV 771

  Fly  1050 EEMMVREPQTNRLYGVKVYSHEVQRIADTQPCHRNNGGCQKICFAVPIGASNGTDGVTTSSPSFG 1114
            ..:....|.   |:|:::|....|: .|.. |..|||||..:|.|:|                .|
Human   772 TLLRHERPP---LFGLQIYDPRKQQ-GDNM-CRVNNGGCSTLCLAIP----------------GG 815

  Fly  1115 RLQSRCSCPYGERLADDQVSCIPDPSAEPPVQPCPNSWDFTCNNQRCIPKSWLCDGDDDCLDNSD 1179
            |:   |:|...:.|.::..:|..:|....| ..| .:.:|.|.|:.||...|.|||||||||.||
Human   816 RV---CACADNQLLDENGTTCTFNPGEALP-HIC-KAGEFRCKNRHCIQARWKCDGDDDCLDGSD 875

  Fly  1180 EEQ-NCTKPTCGSNEFQCRSGRCIPQNFRCDQENDCGDNSDE--QECGNVTCGTSQFACANGRCI 1241
            |:. ||...:|..::|:|::.||||:.:.||..||||.|.||  |.|...||...||:|.|||||
Human   876 EDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCI 940

  Fly  1242 PNMWKCDSENDCGDSSDEGDFCAEKTC-AYFQFTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPP 1305
            |..|.||.|:||||.:||...|...|| ...||.| ::|.||...|.||.||||.|..||..|..
Human   941 PRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVC-KSGRCISSKWHCDSDDDCGDGSDEVGCVH 1004

  Fly  1306 ISCLANQFKCADLRQCVEESYKCDGIPDCNDGSDE--VGCPS---MGPNQCNLEKHFRCKSTGFC 1365
             ||..|||:|:..| |:...:.|||..||.|.|||  :.|..   ..|..|| ...|:|...|.|
Human  1005 -SCFDNQFRCSSGR-CIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCN-GNEFQCHPDGNC 1066

  Fly  1366 IPIAWHCDGSNDCSDHSDEQDC-GQITCA--QNFFKCNNT-NCVFKAYICDGKDDCGDNSDEG-- 1424
            :|..|.|||..||.|.|||:.| |.|...  :..|.|.:| .|:.||::|||..||.|.|||.  
Human  1067 VPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDC 1131

  Fly  1425 AEHACVPPPFKCPHGQWQCPGVSERCVNITSVCDDTPDCPNGSDEGEGCDLAECEHQAGQCSSFC 1489
            ....|.||...|.:.       :..|:....:|:...|||:|||||..||  ||....|.||:.|
Human  1132 DSFLCGPPKHPCAND-------TSVCLQPEKLCNGKKDCPDGSDEGYLCD--ECSLNNGGCSNHC 1187

  Fly  1490 QKTP-NGALCVCPPGSEIGEDGYTCIDSNECDPPGLCSQQCTNTKGSYFCSCTDGYVLEPNKHTC 1553
            ...| .|.:|.||.|.::.:|..||...:.|.....|||.|...|.:..|||.:|:.|:.:..:|
Human  1188 SVVPGRGIVCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESC 1252

  Fly  1554 KAVNHTAAFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGTIFWSDMKLKKISR--- 1615
            .:|:...||:|.|.||.|...||.::....:...:.|.:|...:.:...::|:|:...:|.|   
Human  1253 TSVDPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKL 1317

  Fly  1616 -LDRGMEPQE-IINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQPRG 1678
             ...|:...| ::..||...|||..||||.|:||:||.|:.|||:..:||.|..|:...:..||.
Human  1318 SESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAGAMEHPRA 1382

  Fly  1679 MCIDPSPGARWIFWTDWGEN-PRVERIGMDGTMRKTI---INTKIYWPNGLTLDIATKRVYFADS 1739
            :.:||..|.  :|||||..| ||:|...|.|..||||   :.|.. ||||||:|...||:.:.|:
Human  1383 IALDPRYGI--LFWTDWDANFPRIESASMSGAGRKTIYKDMKTGA-WPNGLTVDHFEKRIVWTDA 1444

  Fly  1740 KLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGKNQTVVSHL 1804
            :.|.|....|:||...:::....||.||.::||:...:||||.:.|.:..|||:.|:|.:|:...
Human  1445 RSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANKWTGQNVSVIQKT 1509

  Fly  1805 ISQPLSIHVHHASLQPMTPNPCAGS----RCQHLCLLSPSAPEGYSCKCRPGFKLLSEGRCIEEE 1865
            .:||..:.::|.|.||..|||||.:    .|.|:||::.:  ...:|.|....||.|:.:...|.
Human  1510 SAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHN--RSAACACPHLMKLSSDKKTCYEM 1572

  Fly  1866 NPFLMVVKGTQIVDLPLNGGDARAGALAPVIGIESSTGLDFDRKGETLYWVQGREDDDENCTIYT 1930
            ..||:..:.::|..:.::...........|..|:..|.:|||...|.|||.     |.:..||  
Human  1573 KKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWT-----DIKTQTI-- 1630

  Fly  1931 TPYGGGNKTLFL---GIENGI---VGAPYTIAFDWLGRNLY-IGNRV-ASNIEAVRVDGKQKYRT 1987
                   |..|:   |:|..|   :.:...:|.||:.|||| |.:.. .:.|...|:||..|...
Human  1631 -------KRAFINGTGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSI 1688

  Fly  1988 IILANDGYPNSVSRPKQIALDPTEGKLFWIDEGVLEVPIKIGRVDMNGQNPIVVFQEFAHPESLA 2052
            |        :.:.:|:.:|..|..|||:|.|...      |...:|:|.|..::||....|..|:
Human  1689 I--------HGIDKPQCLAAHPVRGKLYWTDGNT------INMANMDGSNSKILFQNQKEPVGLS 1739

  Fly  2053 VDTEKKMVYYSASNPAVIGVMDYNGDDHTLI-LMKDSHPMAKPRSLGILDHRLYYLDPLYERIVR 2116
            :|..:..:|:.:|....|...:.:|.:..:| .||:.  :.|..:|.|:|.:|::.|....::..
Human  1740 IDYVENKLYWISSGNGTINRCNLDGGNLEVIESMKEE--LTKATALTIMDKKLWWADQNLAQLGT 1802

  Fly  2117 IDLPHGDNPKTIVDNESDLRSMMIYKKRALM-QHPCQTNNGGCKHLCIPGPGATRTCACGIG-YR 2179
            .....|.||..:.:..|.:..|.:|.|.|.. .:.||.|||||..||:|....||||.|.:| |.
Human  1803 CSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMCTVGYYL 1867

  Fly  2180 KENEINCVAYKIFAVVSQLDMIRGYSL--SDSSEAMVPISGPGHHILHVDVMYREQWIYWAEYNR 2242
            ::|.::|...:.|.:.|..:.|||..|  ||..:|::||||....: .:|.......|||.:.. 
Human  1868 QKNRMSCQGIESFLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAV-GIDFHAENDTIYWTDMG- 1930

  Fly  2243 GYWNGIFRSRPNGTDLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHE-NYVEVCWLDGSNRK 2306
              :|.|.|::.:.|..:.::.:|:|.  :.|:.:||:|||:|:|:   |. |.:||..|:||.|.
Human  1931 --FNKISRAKRDQTWKEDIITNGLGR--VEGIAVDWIAGNIYWTD---HGFNLIEVARLNGSFRY 1988

  Fly  2307 VLVKTTTDAPRELAVNPIKRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHD 2371
            |::....|.||.:||:|.|.||:|.::||.|.||||.||||:...||:.||:.|..::||.:.:.
Human  1989 VIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENK 2053

  Fly  2372 IYWVDSKLDTIQKISY-NGANRKIIRRDLPNPM-GIAVYLNDVYWVDRNLM--TVFKASKHSANE 2432
            :||.|::.|.|::|.. .|.||:::.......| .:||:...:||.||...  :|.:..|:.|.|
Human  2054 LYWCDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATE 2118

  Fly  2433 TATSVRTNL-EKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPPDGGASGTSGGRNFRCE 2496
            |.| :||.| ..|:::.|:  |...:..||.||. .||||.|||.          ..|.....|.
Human  2119 TIT-MRTGLGVNLKEVKIF--NRVREKGTNVCAR-DNGGCKQLCL----------YRGNSRRTCA 2169

  Fly  2497 CATGKLSADERKCEVVNEYLVFATRTEIRAVNL-DPHSTEVPFTPLTN---LTNVVGLDFDF--- 2554
            ||.|.|:.|...|.....||:::.||.:::::| |..:...|..|..|   ..||:.|.||:   
Human  2170 CAHGYLAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNLNSPIRPYENPRYFKNVIALAFDYNQR 2234

  Fly  2555 --AHNRMLYTQIRPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQQKIYWTDSSNNSIYA 2617
              ..||:.|:.    |.....:..|...:|..|::....:.||:||......:|||.|:.:||..
Human  2235 RKGTNRIFYSD----AHFGNIQLIKDNWEDRQVIVENVGSVEGLAYHRAWDTLYWTSSTTSSITR 2295

  Fly  2618 MNLDGSE--------LVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIV 2674
            ..:|.:.        ::.::..:.|..:.||.|...:|:|:|.....|  |.|:|:.|...:.:|
Human  2296 HTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHPS--IMRSTLTGKNAQVVV 2358

  Fly  2675 DKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATIYPF-AITVFRNYIYWTDL 2738
            ..|:..|:||.|||...:||::|....||||.:.||..|.::|.:....| ::.|:.|||:|:|.
Human  2359 STDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVKSGPGTFLSLAVYDNYIFWSDW 2423

  Fly  2739 QLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGKAE 2803
            ..|.:.|:.|:||.:...:...:...|..|...::|...|.::||.:.||||...|...|||:..
Human  2424 GRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVANDTNSCELSPCALLNGGCHDLCLLTPNGRVN 2488

  Fly  2804 CKCDDSTKVVNEGRMCAPRNNTCEA-SKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSC 2867
            |.| ...:::.|...|..:|::|.| |:|.|.||.||....:|||...|.|.|||...||...||
Human  2489 CSC-RGDRILLEDNRCVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSC 2552

  Fly  2868 SPNEFRCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCK 2932
            ......|.|.|||.....||.||||.|.||||.|....|...||.||:|.|||::..||...||.
Human  2553 RRGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCA 2617

  Fly  2933 DNATSDETHERCPMNTTC---------PANHLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHC- 2987
            |  .|||  :.| .||.|         ....::|..|::||.|.|:|||.|||||.|||  |.| 
Human  2618 D--ASDE--KNC-NNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDE--LKCP 2675

  Fly  2988 --GQRTCPTNSFRCPNHRCIPATWYCDGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPR 3050
              .:..|..|.|.||:.|||..||.|||..||.||.||  .:|.|   :|..:.|.|....||.:
Human  2676 VQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDE--FHCDS---SCSWNQFACSAQKCISK 2735

  Fly  3051 IYICDGDNDCLDNSDEDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADE 3115
            .:||||::||.|..||.: ..|....|..:. |:|..:::     |:|:.|:|||:.||.||:||
Human  2736 HWICDGEDDCGDGLDESD-SICGAITCAADM-FSCQGSRA-----CVPRHWLCDGERDCPDGSDE 2793

  Fly  3116 NTTLHNCATQQPCGEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNF 3180
            .:|. .||....|.|:.|.|.|..||.|.::||||:|||||:||...|.  |:.|..:||:|.:.
Human  2794 LSTA-GCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCG--YRQCGTEEFSCADG 2855

  Fly  3181 KCIRN-QSRCDGEDDCGDHSDEV----GCAKENITCPQGQFACTNGQCIDYNLVCNKYPDCADES 3240
            :|:.| |.:|||:.||.|||||.    .|.....:|....|.|.||:||....:|:...||.|.|
Human  2856 RCLLNTQWQCDGDFDCPDHSDEAPLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGS 2920

  Fly  3241 DEPAHCNVDECAKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACSQHCS 3305
            || .:|:::||...:::.|...|.|....|.|.|..|::|..|||.|.|:||| .....|||.|.
Human  2921 DE-RNCHINECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDIDEC-SSGFPCSQQCI 2983

  Fly  3306 NTPGGFYCKCDETYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNLMHQDLMNVVAL 3370
            ||.|.:.|.|.:.|..:.::.:.||......|:||..:.:.:|.:|.||..|.|:.|.|.||:|:
Human  2984 NTYGTYKCLCTDGYEIQPDNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAI 3048

  Fly  3371 DFDIREEYMYFCDVT---AKTIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAIDWVGRKLYWLD 3432
            |||.|||::|:.|.:   ...|.|.....:|.:        :.|::.....:|:||:|:.|||.|
Human  3049 DFDYREEFIYWIDSSRPNGSRINRMCLNGSDIK--------VVHNTAVPNALAVDWIGKNLYWSD 3105

  Fly  3433 RHSKNLDVSELDG-------SKRKTLRSGVVDPRAIVVHPGIGYLYFTSWHLQAYIAKMGMDGSN 3490
            ...:.::||:|:|       |||...      ||.:.:.|..||||:.......:|.::||||:|
Human  3106 TEKRIIEVSKLNGLYPTILVSKRLKF------PRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTN 3164

  Fly  3491 FSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVLSGSKVPHVFALSLFD 3555
            .|.::...  |:.|.||:|||...|:||||.  ::|.:::::|.|||.| ....:|.|.||:||:
Human  3165 QSVVIETK--ISRPMALTIDYVNRRLYWADE--NHIEFSNMDGSHRHKV-PNQDIPGVIALTLFE 3224

  Fly  3556 DYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHINHPLRQLPYT-NPCGTNNGGCSHLCL 3619
            |||||:|...|::.||:|..||:...|..:.|...|:.:.|..||...: :.|..||||||||||
Human  3225 DYIYWTDGKTKSLSRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCL 3289

  Fly  3620 IAPPPESTYLNIEGYIEEGAPIFKCACPNQFYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKC 3684
            :||....|                ||||..||||.|.:||::||||.|..|  :.:||||::|||
Human  3290 LAPGKTHT----------------CACPTNFYLAADNRTCLSNCTASQFRC--KTDKCIPFWWKC 3336

  Fly  3685 DGEKDCKDGSDEPATCAPRHCRAGTFQCKNTNCTPSATICDGVDDCGDRSDEQNCD--------- 3740
            |...||.||||||..|....|:.|.|||....|...|.||||.:||||.|||.|||         
Human  3337 DTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQF 3401

  Fly  3741 --------LP-------------------CPLSD-----FKCKSSGRCILDSWRCDGDADCKDGS 3773
                    :|                   ||.:.     |:||::..||...|.||.|.||.|.|
Human  3402 KCTKNQKCIPVNLRCNGQDDCGDEEDERDCPENSCSPDYFQCKTTKHCISKLWVCDEDPDCADAS 3466

  Fly  3774 DEDPAVCFKRTCDPKTEFSCKNGRCIPQLWMCDFDNDCGDDSDEPAYMCRQRNCTTGWQRCPGQS 3838
            ||  |.|.|:||.|. ||.|||..|||..|.||..|||.|:|||.  .|:.:.||.....|   :
Human  3467 DE--ANCDKKTCGPH-EFQCKNNNCIPDHWRCDSQNDCSDNSDEE--NCKPQTCTLKDFLC---A 3523

  Fly  3839 NYRCIPKWLFCDGKDDCRDNSDELPENCPKCNPETDFKCGNNRCIPKQWMCDFADDCGDASDENE 3903
            |..|:....:|||..||.|.|||  .||.....:..|:|.|.:|||.:|.||..:||....||..
Human  3524 NGDCVSSRFWCDGDFDCADGSDE--RNCETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKS 3586

  Fly  3904 AVCKGRYRECSESEFRCGNGKCISSRWQCDHEDDCGDNSDEMHCEGYQCKNGTFQCAS-GHCIAS 3967
              |:.....||..|:.|.:..|||:..:|:.|.||.|.||||.|. .:||...|:|.: .|||..
Human  3587 --CEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCV-TECKEDQFRCKNKAHCIPI 3648

  Fly  3968 YFRCDGDRDCRDMSDEVGCPPRFPGGRYCPESRFQCNNNLCVSLSDLCDGTDDCGDGSDEDPSVC 4032
            .:.|||..||.|.|||..|.   .||..|....|.|||:||.....:|||.|||||.|||.|.:|
Human  3649 RWLCDGIHDCVDGSDEENCE---RGGNICRADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMC 3710

  Fly  4033 SDFNCDTLRRFQCSNER-CVARYQICDGVDNCGDGSDENNMTLCAS----KQKPCDLYTQYQCAN 4092
            ..|.|.:.|..:|.|.| |:...|:|:|:|.|||.|||::   |..    |.:||. ..::.|:|
Human  3711 VKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDH---CGGKLTYKARPCK-KDEFACSN 3771

  Fly  4093 KHCIERSQVCDFSDDCGDASDELGCHHTS---SCSE-ANRGGCQQHCHNLTDGGYICTCYPGYII 4153
            |.||.....||..|||||.|||.||....   :|.: .|..|...:|:.:....: |.|.||:..
Human  3772 KKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVF-CRCKPGFQR 3835

  Fly  4154 AADNKKKCSDVDECLTRQHTCSHQCHNLNGTYSCSCREGFHLTDGASGVCRAE-KEDVILLFVNG 4217
            ...| ::|.|::|||. ..||||||.|:.|:|.|.|.:.|   ...:..|.|| .||.:|...|.
Human  3836 NMKN-RQCEDLNECLV-FGTCSHQCINVEGSYKCVCDQNF---QERNNTCIAEGSEDQVLYIAND 3895

  Fly  4218 QEIRG----LNWH-KSEEFAVIAAEKRIEALDYDAQQQIVFWADSYDKTIKRSYMVNAIDGRAKI 4277
            .:|.|    .|:. ..::.:.|....||..:|...|:.::.|:..::   ........|.||.|.
Human  3896 TDILGFIYPFNYSGDHQQISHIEHNSRITGMDVYYQRDMIIWSTQFN---PGGIFYKRIHGREKR 3957

  Fly  4278 GFAQDLNMKGGSKPTAVAVDWLASNLYWTEMDRT---------GSKPRGRVMVAKTDG-RYRRSI 4332
            .....|......:|..:||||:|.|:|||:..|.         .:..|..:.|.:.:| ...|.:
Human  3958 QANSGLICPEFKRPRDIAVDWVAGNIYWTDHSRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLL 4022

  Fly  4333 VNAGLEVPTSIAVNPQLGRIYWSDAGSAPKIEVSWMDGSKRRPLITEMIRHPAGLTIDYSQDHII 4397
            .|...| |.:|||||:.|.:||:..|....||.:.|||:.||.|:.:.::.|.||.:||..:. |
Human  4023 TNMAGE-PYAIAVNPKRGMMYWTVVGDHSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSER-I 4085

  Fly  4398 YWVDTKLNAIESMRADGSRRKAIVRGDQ-LRHPVSLDLFESNMFWMTRDTGELVRQDKFGRGVQV 4461
            ||.|.:|:.|.|:..|||.....|...| |.||..:|:||..::......| :.|..|||.|...
Human  4086 YWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIYGAGPKNG-VFRVQKFGHGSVE 4149

  Fly  4462 VLHRYIVNPSGLKVYHDKRY-NTSLPNPCDNSTCSHLCLLVPGGHRCACPDASGPPPSHRSTAEV 4525
            .|...|....|:.:.|  || ...|||||.:..|..||||.|.|..|.||:           .:.
Human  4150 YLALNIDKTKGVLISH--RYKQLDLPNPCLDLACEFLCLLNPSGATCVCPE-----------GKY 4201

  Fly  4526 ICNAAAEHPRPAPRIC--PCQNGGLCKEDAQGELLCECRTQFVGEHCETS 4573
            :.|............|  .|:|||.|..:.:|:|.|.|...:.||.||.:
Human  4202 LINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCEVN 4251

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060 3/7 (43%)
LDLa 332..366 CDD:238060 12/34 (35%)
LDLa 371..412 CDD:238060 19/40 (48%)
vWFA <447..488 CDD:294047 22/40 (55%)
NHL 573..>716 CDD:302697 47/145 (32%)
NHL repeat 573..610 CDD:271320 10/36 (28%)
NHL repeat 616..654 CDD:271320 15/40 (38%)
NHL repeat 657..693 CDD:271320 13/35 (37%)
FXa_inhibition 763..805 CDD:291342 13/45 (29%)
LY 922..964 CDD:214531 17/48 (35%)
LY 973..1007 CDD:214531 16/33 (48%)
Ldl_recept_a 1188..1223 CDD:278486 17/36 (47%)
LDLa 1227..1259 CDD:197566 19/31 (61%)
LDLa 1268..1303 CDD:238060 17/35 (49%)
LDLa 1308..1343 CDD:238060 16/36 (44%)
LDLa 1356..1387 CDD:238060 15/30 (50%)
LDLa 1391..1423 CDD:197566 13/34 (38%)
LDLa 1435..1469 CDD:197566 8/33 (24%)
FXa_inhibition 1478..1513 CDD:291342 12/35 (34%)
FXa_inhibition 1522..1553 CDD:291342 10/30 (33%)
LY 1625..1665 CDD:214531 20/39 (51%)
LY 1667..1711 CDD:214531 17/44 (39%)
Ldl_recept_b 1690..1728 CDD:278487 22/41 (54%)
LY 1712..1754 CDD:214531 19/44 (43%)
LY 1986..2037 CDD:214531 12/50 (24%)
FXa_inhibition 2151..>2179 CDD:291342 16/28 (57%)
LY 2259..2305 CDD:214531 17/46 (37%)
Ldl_recept_b 2326..2366 CDD:278487 19/39 (49%)
LY 2352..2392 CDD:214531 14/40 (35%)
NHL 2579..>2711 CDD:302697 41/139 (29%)
NHL repeat 2593..2622 CDD:271320 10/28 (36%)
NHL repeat 2634..2678 CDD:271320 13/43 (30%)
LY 2671..2713 CDD:214531 17/41 (41%)
LDLa 2867..2901 CDD:238060 17/33 (52%)
LDLa 2906..2941 CDD:238060 17/34 (50%)
LDLa 2950..2983 CDD:238060 17/41 (41%)
LDLa 3034..3066 CDD:197566 12/31 (39%)
LDLa 3080..3115 CDD:197566 12/34 (35%)
LDLa 3128..3159 CDD:238060 17/30 (57%)
LDLa 3170..3204 CDD:238060 17/38 (45%)
LDLa 3210..3242 CDD:197566 12/31 (39%)
cEGF 3269..3292 CDD:289433 10/22 (45%)
vWFA <3284..3324 CDD:294047 17/39 (44%)
LY 3362..3394 CDD:214531 15/34 (44%)
LY 3406..3448 CDD:214531 14/48 (29%)
LY 3498..3536 CDD:214531 14/37 (38%)
LY 3536..3578 CDD:214531 20/41 (49%)
FXa_inhibition 3607..3659 CDD:291342 23/51 (45%)
LDLa 3663..3696 CDD:238060 18/32 (56%)
LDLa 3705..3739 CDD:238060 18/33 (55%)
LDLa 3743..3775 CDD:197566 15/36 (42%)
LDLa 3784..3817 CDD:197566 19/32 (59%)
LDLa 3827..3861 CDD:197566 12/33 (36%)
LDLa 3871..3901 CDD:197566 11/29 (38%)
LDLa 3913..3947 CDD:238060 16/33 (48%)
LDLa 3952..3986 CDD:238060 16/34 (47%)
LDLa 3996..4027 CDD:197566 16/30 (53%)
LDLa 4043..4071 CDD:238060 14/28 (50%)
LDLa 4086..4117 CDD:238060 15/30 (50%)
EGF_CA 4163..4194 CDD:214542 15/30 (50%)
NHL 4276..>4426 CDD:302697 54/160 (34%)
NHL repeat 4291..4336 CDD:271320 16/54 (30%)
Ldl_recept_b 4350..4390 CDD:278487 15/39 (38%)
NHL repeat 4376..4422 CDD:271320 16/45 (36%)
LRP1BNP_061027.2 FXa_inhibition 165..193 CDD:291342 14/27 (52%)
NHL 282..459 CDD:302697 54/180 (30%)
NHL repeat 285..321 CDD:271320 10/35 (29%)
LDL-receptor class B 1 295..337 12/41 (29%)
LY 319..361 CDD:214531 15/41 (37%)
NHL repeat 328..367 CDD:271320 15/38 (39%)
LDL-receptor class B 2 338..381 11/42 (26%)
NHL repeat 371..406 CDD:271320 13/34 (38%)
LDL-receptor class B 3 382..425 18/42 (43%)
NHL repeat 415..445 CDD:271320 7/30 (23%)
FXa_inhibition 483..516 CDD:291342 12/37 (32%)
LY 548..590 CDD:214531 15/45 (33%)
LDL-receptor class B 4 568..610 17/41 (41%)
LY 591..630 CDD:214531 16/38 (42%)
LDL-receptor class B 5 611..656 17/44 (39%)
LY 637..686 CDD:214531 16/48 (33%)
LDL-receptor class B 6 657..706 15/48 (31%)
LY 687..729 CDD:214531 18/41 (44%)
LDL-receptor class B 7 707..750 18/42 (43%)
FXa_inhibition 798..833 CDD:291342 14/53 (26%)
LDLa 886..919 CDD:238060 16/32 (50%)
LDLa 926..958 CDD:197566 19/31 (61%)
LDLa 1006..1038 CDD:238060 15/32 (47%)
LDLa 1053..1088 CDD:238060 17/35 (49%)
LDLa 1097..1131 CDD:238060 15/33 (45%)
LDLa 1136..1169 CDD:238060 11/39 (28%)
FXa_inhibition 1176..1212 CDD:291342 12/35 (34%)
LY 1280..1318 CDD:214531 6/37 (16%)
LDL-receptor class B 8 1300..1346 13/45 (29%)
LY 1327..1367 CDD:214531 19/39 (49%)
LDL-receptor class B 9 1347..1389 17/41 (41%)
LY 1371..1414 CDD:214531 17/44 (39%)
LDL-receptor class B 10 1390..1436 24/48 (50%)
LY <1426..1458 CDD:214531 14/31 (45%)
LDL-receptor class B 11 1437..1480 14/42 (33%)
LDL-receptor class B 12 1481..1522 14/40 (35%)
LDL-receptor class B 13 1618..1660 15/55 (27%)
Ldl_recept_b 1618..1657 CDD:278487 13/52 (25%)
LY 1641..1683 CDD:214531 13/41 (32%)
LDL-receptor class B 14 1661..1704 14/50 (28%)
LY 1685..1724 CDD:214531 13/52 (25%)
LDL-receptor class B 15 1705..1744 14/44 (32%)
LY <1735..1766 CDD:214531 7/30 (23%)
LDL-receptor class B 16 1745..1787 10/43 (23%)
FXa_inhibition 1838..1874 CDD:291342 18/35 (51%)
NHL 1913..2138 CDD:302697 82/236 (35%)
NHL repeat 1913..1952 CDD:271320 8/42 (19%)
LDL-receptor class B 17 1922..1964 12/46 (26%)
LY 1947..1987 CDD:214531 17/44 (39%)
NHL repeat 1957..1994 CDD:271320 17/39 (44%)
LDL-receptor class B 28 1965..2007 19/44 (43%)
NHL repeat 1998..2036 CDD:271320 21/37 (57%)
LDL-receptor class B 19 2008..2051 21/42 (50%)
Ldl_recept_b 2008..2048 CDD:278487 19/39 (49%)
LY 2033..2075 CDD:214531 14/41 (34%)
NHL repeat 2042..2080 CDD:271320 12/37 (32%)
LDL-receptor class B 20 2052..2095 12/42 (29%)
NHL repeat 2089..2128 CDD:271320 15/39 (38%)
FXa_inhibition 2147..2182 CDD:291342 16/45 (36%)
LDL-receptor class B 21 2239..2280 11/44 (25%)
LDL-receptor class B 22 2281..2329 10/47 (21%)
LDL-receptor class B 23 2330..2374 16/45 (36%)
Ldl_recept_b 2330..2371 CDD:278487 13/42 (31%)
LY 2355..2397 CDD:214531 17/41 (41%)
LDL-receptor class B 24 2375..2416 13/40 (33%)
LDL-receptor class B 25 2417..2459 11/41 (27%)
LDLa 2514..2543 CDD:238060 14/28 (50%)
LDLa 2552..2586 CDD:238060 17/33 (52%)
LDLa 2591..2625 CDD:238060 17/37 (46%)
LDLa 2682..2716 CDD:238060 19/35 (54%)
LDLa 2720..2753 CDD:238060 14/32 (44%)
LDLa 2760..2793 CDD:197566 13/38 (34%)
LDLa 2844..2877 CDD:197566 15/32 (47%)
LDLa 2891..2925 CDD:238060 14/34 (41%)
cEGF 2948..2971 CDD:289433 10/22 (45%)
EGF_CA 2968..2998 CDD:214542 13/30 (43%)
LY 3035..3079 CDD:214531 17/43 (40%)
LDL-receptor class B 26 3055..3098 10/50 (20%)
LY 3080..3118 CDD:214531 12/45 (27%)
LDL-receptor class B 27 3099..3141 14/47 (30%)
LY 3123..3164 CDD:214531 15/46 (33%)
LDL-receptor class B 28 3142..3185 18/44 (41%)
LY 3167..3206 CDD:214531 14/42 (33%)
LDL-receptor class B 29 3186..3224 16/40 (40%)
LDL-receptor class B 30 3225..3268 16/42 (38%)
FXa_inhibition 3277..3313 CDD:291342 23/51 (45%)
LDLa 3317..3348 CDD:197566 18/32 (56%)
LDLa 3357..3391 CDD:238060 18/33 (55%)
LDLa 3396..3431 CDD:238060 1/34 (3%)
LDLa 3436..3471 CDD:238060 16/36 (44%)
LDLa 3476..3510 CDD:238060 20/36 (56%)
LDLa 3515..3549 CDD:238060 14/38 (37%)
LDLa 3553..3587 CDD:238060 13/35 (37%)
LDLa 3594..3628 CDD:238060 16/33 (48%)
LDLa 3632..3667 CDD:238060 16/34 (47%)
LDLa 3674..3706 CDD:238060 17/31 (55%)
LDLa 3721..3751 CDD:238060 14/32 (44%)
LDLa 3762..3796 CDD:238060 16/34 (47%)
EGF_CA 3844..3878 CDD:214542 16/37 (43%)
LDL-receptor class B 31 3933..3980 11/49 (22%)
LDL-receptor class B 32 3981..4038 17/57 (30%)
LDL-receptor class B 33 4039..4082 17/42 (40%)
Ldl_recept_b 4039..4079 CDD:278487 15/39 (38%)
LY 4063..4102 CDD:214531 14/39 (36%)
LDL-receptor class B 34 4083..4127 18/44 (41%)
Endocytosis signal. /evidence=ECO:0000255 4492..4495
Endocytosis signal. /evidence=ECO:0000255 4559..4562
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 137 1.000 Domainoid score I4897
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1326at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 1 1.100 - - LDO PTHR22722
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.820

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