DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and sorl1

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:XP_005157607.1 Gene:sorl1 / 497306 ZFINID:ZDB-GENE-050208-22 Length:2213 Species:Danio rerio


Alignment Length:1780 Identity:449/1780 - (25%)
Similarity:680/1780 - (38%) Gaps:508/1780 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  3199 SDEVGCAKENITCPQGQFAC-------TNGQCIDYNLVCNK---YPDC--ADESDEPAHCNVDEC 3251
            ||.:|     :.|.:|.:..       .||..:...:|..:   :..|  .::.|.|        
Zfish   619 SDVLG-----VPCSEGDYKLWSPSDERGNGCLLGREMVYKRRSPHATCFNGEDFDRP-------- 670

  Fly  3252 AKVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACSQHCSNTPGGFY---- 3312
              :.::.|  .|  |...|.||  .|:||..|    ..::.|:..|        ...|..|    
Zfish   671 --ISLSNC--SC--TRQDYECD--YGFKLSED----LSLEVCVPDP--------EFSGNLYAPPV 715

  Fly  3313 -CKCDETYYE----RQNDEHTCKRKD--------KIPPWLIFTNK---YYVRNMSVDGHQYNL-- 3359
             |....||:.    |:....:|...|        .:|..:..:|:   |.||| |:  |:|:|  
Zfish   716 PCPVGTTYHRSKGYRKVSGDSCTGGDVEARLDGENLPCPVGESNEFILYAVRN-SI--HRYDLAS 777

  Fly  3360 ----------MHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPEREAVIRHDSH 3414
                      :|:    .||||||..:..:|:.|::..||.|.....:..:     |.:::.|..
Zfish   778 GTDQQLPLTGLHE----AVALDFDYEKNCLYWADISLDTIQRLCMNGSSGQ-----EVIVKRDLQ 833

  Fly  3415 GLEGIAIDWVGRKLYWLDRHSKNLDVSELDGSKRKTL-RSGVVD-PRAIVVHPGIGYLYFTSW-H 3476
            .:|.::.|.:.|.|||:|..::.::||..||..|:|| .|.||| |||:.:.|....:::|.| .
Zfish   834 NVEALSFDPISRLLYWVDAGAQKIEVSNSDGDLRRTLVNSSVVDQPRALALMPAESLMFWTDWGD 898

  Fly  3477 LQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEGRHRHTVLS 3541
            ..|.:.:..|||||.|.|:  ::|:.|||.::.|  ...:||.:|:.|.|..||..|..|..::.
Zfish   899 RAAGVYRSWMDGSNISCIV--SEGVRWPNGITAD--ESWLYWTEAYGDRIERADFNGGSRTVIME 959

  Fly  3542 GSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHINHPLRQLPYTNP 3606
            |  :||.:|:::|.:.:||.||:...|.:|.|....:..::........||.|.:.         
Zfish   960 G--LPHPYAIAVFKNDLYWDDWSRMGIFKAPKSGSPDSELIVGRLTGVMDLKIFYK--------- 1013

  Fly  3607 CGTNNG-------GCSHLCLIAPPPESTYLNIEGYIEEGAPIF-------KCACPNQFYLARDMK 3657
             |.|.|       .||.|||..|..:...:     ..:|.|..       :|.||:.:.|..:  
Zfish  1014 -GKNRGQNACADQPCSLLCLPQPGNQRHCV-----CPDGVPTSVLPSGERQCQCPSGYQLHNN-- 1070

  Fly  3658 TCVA---NCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDE---PAT-CAPRHCRAGTFQC-KN 3714
            |||.   .|...||.|.  :.|||...||||.:.||.|.|||   |.| |.|    :..|:| .:
Zfish  1071 TCVKTEHTCLPNQHRCA--NGKCISSIWKCDSDNDCGDMSDEQECPTTSCDP----SVQFRCVAS 1129

  Fly  3715 TNCTPSATICDGVDDCGDRSDEQNCDL-PCPLSDFKCKSSGRCILDSWRCDGDADCKDGSDEDPA 3778
            .:|.|.|..||..|||||.|||::|:. .|...:|.| :.|.||.|:||||||.||:|.|||...
Zfish  1130 GSCIPLAFKCDHEDDCGDNSDEEHCESHKCGPGEFTC-ARGACIRDAWRCDGDNDCRDWSDEANC 1193

  Fly  3779 VCFKRTCDPKTEFSCKNGRCIPQLWMCDFDNDCGDDSDEPAYMCRQRNCTTGWQRCPG--QSNYR 3841
            .....||: .:.|.|..|.||||.|:||.|:||.|.|||....|       |.|:|.|  .||..
Zfish  1194 TVGHHTCE-SSSFQCHTGHCIPQRWVCDGDDDCQDGSDEDPTQC-------GRQKCNGFLCSNGT 1250

  Fly  3842 CIPKWLFCDGKDDCRDNSDELPENC-PKCNPETDFKCGNN-RCIPKQWMCDFADDCGDASDENEA 3904
            |:|....|:|.:||...:||  :|| |.|....:|.|.|. :|:.:..:||....|.|.|||:..
Zfish  1251 CLPASAHCNGVEDCPGGADE--QNCGPLCAHYMEFVCRNRAQCLFQSLVCDGTRHCADGSDEDPI 1313

  Fly  3905 VCKGRYRECSES----------EFRCGNGKCISSRWQCDHEDDCGDNSDEMHCEGYQCKNG---- 3955
                 |..||.|          .|:|.||.|::..|:||..|||||.|||.:|.....:.|    
Zfish  1314 -----YAGCSTSVEFEKTCDGYNFQCTNGMCVTLEWKCDGMDDCGDYSDEANCASPTEEPGCTSY 1373

  Fly  3956 -TFQCASGHCIASYFRCDGDRDCRDMSDEVGC-------PPRFPGGRYCPESRFQCNNNLCVSLS 4012
             .|:|.:|.|:.::::|||:.||.|.|||..|       .|. ||...|..:||:|.:..|:..:
Zfish  1374 FRFECKNGRCVPAWWKCDGENDCGDWSDESQCSGGEALHTPA-PGPATCAPNRFRCGSGACIVDT 1437

  Fly  4013 DLCDGTDDCGDGSDEDPSVCSDFNCDTLR------------------RFQC-SNERCVARYQICD 4058
            .:|||..||.|.|||       ..|.|::                  :|.| ....|::.::.||
Zfish  1438 WVCDGYADCPDSSDE-------AGCPTVKGSVTSVTTLPPSGRCTKDQFLCVKPPACISDWKRCD 1495

  Fly  4059 GVDNCGDGSDENNMTLCASKQKPCDLYTQYQCAN-------KHCIERSQVCDFSDDCGDASDELG 4116
            |..:|.|||||.|          |..:....|||       :.|:..|:.||...||.|.|||..
Zfish  1496 GHSHCLDGSDEAN----------CPTHGPLLCANGTRCADGEACLLNSERCDGFIDCSDRSDEHN 1550

  Fly  4117 CHH-------------------------------TSSCSEA---NRGGCQQHCH---NLTDGGYI 4144
            |..                               |||||..   ...|.||...   |...|..:
Zfish  1551 CTDEQQVYKVQNLQWTANFSGAVKLTWTRPKNMPTSSCSFVIYFRPVGVQQWTSIDTNSNKGSAV 1615

  Fly  4145 CTCYPGYIIAADNKKKCSDVDECLTRQHTCSH-------------------QCHNL-NGTYSCS- 4188
            .|     ::..|.........:||::||..:.                   .|... :||..|| 
Zfish  1616 LT-----VLMPDTTYNVKVQTQCLSKQHRTNEYLTLRTPEGLPDPPQSLQLSCDKADDGTVLCSW 1675

  Fly  4189 ---------------------CREGFHLTDGASG--VCRAEKEDVILLFVNGQEIRGL-NWHKSE 4229
                                 ..|.|.|:..::.  |...:...:....|.....||: ||   .
Zfish  1676 SPPDKTHGHIREYIVEYSEKDSAEWFSLSSTSTNAEVKNLQPSSLYRFRVAAVTSRGVGNW---T 1737

  Fly  4230 EFAVIAAEKRIE------------------ALDYDAQQQ----IVFWA------DSYDKTIKRSY 4266
            |...|..:|.:.                  :.||..:.:    ::.|.      :|::.|:..:.
Zfish  1738 EIKSIIPQKALSPPKVTITSITEDSMSLSISNDYKVKVKLYIVVISWVFDEHVKESWNYTVPETL 1802

  Fly  4267 MVNAIDGRAKIGFAQDLNMKGGSKPTAV------------------AVDWLASNLYWT----EM- 4308
            .|:.:....:...|...:...|..|||:                  |::..|.:..||    || 
Zfish  1803 KVSNLTAGTEYEVAVWAHTDDGDSPTALSRQQTKGSRPVQPSLKARALNQTAVDCNWTGPPAEMY 1867

  Fly  4309 ---------------DRTGSKPRGRVMVAKTDGRY--RRSIVNAGLEVPTSIAVNPQLGRIYWSD 4356
                           .|..|......::..:|.:|  ...:|:..:..|::.||...:     .|
Zfish  1868 AVFYATSFLDLFRRPHRVNSTSSSLTVIVDSDEQYLFLVRVVSPYMGPPSNYAVVKMI-----PD 1927

  Fly  4357 AGSAP----KIEV-------SWMD--GSKRRPL-----ITEMIRHPAGLTIDYSQDHIIYWVDTK 4403
            ....|    |:.|       .|..  .|...||     :.:.:|....   ||.       |.|:
Zfish  1928 ERLPPRNLHKVRVDKTQATLKWQPPYDSPSSPLTYAVHVRDTVRKTES---DYK-------VITQ 1982

  Fly  4404 LNAIE-------------------SMRADGSRRKAIVRGDQLRHPVSLDLFESN----MFWMTRD 4445
            .|.:|                   :|..:.|...:.|   .|..|.:|.:.|..    :||.:  
Zfish  1983 NNTVEYTLKGLEPAGRYSITIRLLNMSKEASYTLSTV---PLPAPEALKILEEEDHVFLFWKS-- 2042

  Fly  4446 TGELVRQDKF---GRGVQVVLHRYIVNPSGLKVYHDKRYNTSLPNPCDNSTCSHLCLLVPGGHRC 4507
               |..:|:.   .||.:|.:|..:.|.:           ..|.|..:  |...:..|:.|    
Zfish  2043 ---LAVKDRTFNESRGYEVYVHDSVTNST-----------KCLGNTTE--TFFRINSLLAG---- 2087

  Fly  4508 ACPDASGPPPSHRSTAEVICNAAAEHPRPAPRICPCQNGGLCKEDAQGELLCECRTQFVGEHCET 4572
                       |..|..|...            |...| .||.|.|  .||.:...:..|::...
Zfish  2088 -----------HNYTFSVRAR------------CLLSN-QLCGESA--VLLYDELGKAAGQNDAA 2126

  Fly  4573 STMGAFGHGDANVTAVVVPIMVILLVMMAAAGAWYVIRKR----PFGKLARMPAMTSSQSVTFRH 4633
            |..|.    ..::.|:|||::.:|||.:........:|.|    .|...|.....:...|..|..
Zfish  2127 SQSGK----SEDMAAIVVPVLFLLLVGVCGGLVVLYLRHRRLQHSFTAFANSHYNSRLGSAIFSS 2187

  Fly  4634 GSNVEFNESGFPGASAPGAGDVAPI 4658
            |..:..::...|..|  |..|..|:
Zfish  2188 GDELGDDDEDAPMIS--GFSDDVPM 2210

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1728 CDD:278487
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060 2/4 (50%)
LDLa 3210..3242 CDD:197566 6/43 (14%)
cEGF 3269..3292 CDD:289433 7/22 (32%)
vWFA <3284..3324 CDD:294047 8/48 (17%)
LY 3362..3394 CDD:214531 11/31 (35%)
LY 3406..3448 CDD:214531 13/41 (32%)
LY 3498..3536 CDD:214531 13/37 (35%)
LY 3536..3578 CDD:214531 13/41 (32%)
FXa_inhibition 3607..3659 CDD:291342 15/65 (23%)
LDLa 3663..3696 CDD:238060 15/32 (47%)
LDLa 3705..3739 CDD:238060 15/34 (44%)
LDLa 3743..3775 CDD:197566 17/31 (55%)
LDLa 3784..3817 CDD:197566 17/32 (53%)
LDLa 3827..3861 CDD:197566 12/35 (34%)
LDLa 3871..3901 CDD:197566 9/30 (30%)
LDLa 3913..3947 CDD:238060 19/43 (44%)
LDLa 3952..3986 CDD:238060 14/38 (37%)
LDLa 3996..4027 CDD:197566 12/30 (40%)
LDLa 4043..4071 CDD:238060 12/28 (43%)
LDLa 4086..4117 CDD:238060 13/37 (35%)
EGF_CA 4163..4194 CDD:214542 10/72 (14%)
NHL 4276..>4426 CDD:302697 37/226 (16%)
NHL repeat 4291..4336 CDD:271320 14/84 (17%)
Ldl_recept_b 4350..4390 CDD:278487 9/57 (16%)
NHL repeat 4376..4422 CDD:271320 10/69 (14%)
sorl1XP_005157607.1 VPS10 130..754 CDD:214740 32/167 (19%)
Sortilin_C 589..754 CDD:292523 32/167 (19%)
LY 781..822 CDD:214531 12/44 (27%)
LY 825..864 CDD:214531 11/38 (29%)
LY 868..912 CDD:214531 16/43 (37%)
LY 916..954 CDD:214531 14/41 (34%)
LDLa 1079..1113 CDD:238060 17/35 (49%)
LDLa 1118..1154 CDD:238060 17/39 (44%)
LDLa 1159..1193 CDD:238060 19/34 (56%)
LDLa 1242..1273 CDD:238060 11/32 (34%)
LDLa 1282..1310 CDD:197566 9/27 (33%)
LDLa 1327..1361 CDD:238060 16/33 (48%)
LDLa 1376..1405 CDD:238060 13/28 (46%)
LDLa 1421..1455 CDD:238060 14/40 (35%)
LDLa 1474..1509 CDD:238060 13/44 (30%)
LDLa 1522..1551 CDD:238060 10/28 (36%)
FN3 1559..>1630 CDD:238020 12/75 (16%)
FN3 1653..1743 CDD:238020 15/92 (16%)
FN3 1750..1827 CDD:238020 8/76 (11%)
FN3 1931..2007 CDD:238020 14/85 (16%)
FN3 2022..2097 CDD:214495 20/107 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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