DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and LRP5

DIOPT Version :10

Sequence 1:NP_572563.3 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:XP_011543331.1 Gene:LRP5 / 4041 HGNCID:6697 Length:1662 Species:Homo sapiens


Alignment Length:1504 Identity:463/1504 - (30%)
Similarity:718/1504 - (47%) Gaps:161/1504 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly  1519 CDPPGLCSQQCTNTKGSYFCSCTDGYVLEPNKHTCKAVNHTAAFLIISNRHSILVADLKEQGLER 1583
            |...|:.:.||.:::.              .|.........:..|:.:||..:.:.|.....||.
Human    14 CRKGGVRAGQCLSSRN--------------GKEEAAQYFPASPLLLFANRRDVRLVDAGGVKLES 64

  Fly  1584 VPII--VENVVATASNMHTGTIFWSDMKLKKISRL---DRGMEPQEIINTGLDLVEGLAYDWIAQ 1643
            ..::  :|:..|.......|.::|:|:..:.|.:.   ..|...|.::.:||...:|||.||:.:
Human    65 TIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYLNQTGAAVQNVVISGLVSPDGLACDWVGK 129

  Fly  1644 NLYWLDSKLNTIEVSAENGSNRLVLVRENITQPRGMCIDPSPGARWIFWTDWGENPRVERIGMDG 1708
            .|||.||:.|.|||:..||::|.||..:::.|||.:.:||:.|  :::||||||.||:||.||||
Human   130 KLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAHG--YMYWTDWGETPRIERAGMDG 192

  Fly  1709 TMRKTIINTKIYWPNGLTLDIATKRVYFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLF 1773
            :.||.|:::.||||||||:|:..:::|:||:||.||.....:|:.||:|:..|  |.||.:|:|.
Human   193 STRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGS--LTHPFALTLS 255

  Fly  1774 EDTLYWTDRQLNRVLSANK-FRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCA--GSRCQHLC 1835
            .|||||||.|...:.:.|| ..||.:.::|.|.| |:.|.|.....||.....|.  ...|.|||
Human   256 GDTLYWTDWQTRSIHACNKRTGGKRKEILSALYS-PMDIQVLSQERQPFFHTRCEEDNGGCSHLC 319

  Fly  1836 LLSPSAPEGYSCKCRPGFKLLSEGR-CIEEENPFLMVVKGTQIVDLPLNGGDARAGALAPVIGIE 1899
            |||||.| .|:|.|..|.:|...|| |.......|::.:.|.:..:.|:..|. ...:..|..|.
Human   320 LLSPSEP-FYTCACPTGVQLQDNGRTCKAGAEEVLLLARRTDLRRISLDTPDF-TDIVLQVDDIR 382

  Fly  1900 SSTGLDFDRKGETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGIENGIVGAPYTIAFDWLGRNL 1964
            .:..:|:|.....:||.    ||:..........|.|.:||.    |..:..|..||.||:.|||
Human   383 HAIAIDYDPLEGYVYWT----DDEVRAIRRAYLDGSGAQTLV----NTEINDPDGIAVDWVARNL 439

  Fly  1965 YIGNRVASNIEAVRVDGKQKYRTIILANDGYPNSVSRPKQIALDPTEGKLFWIDEGVLEVPIKIG 2029
            |..:.....||..|::|..  |.|:::.|     :..|:.|||.|..|.::|.|.|  |.| ||.
Human   440 YWTDTGTDRIEVTRLNGTS--RKILVSED-----LDEPRAIALHPVMGLMYWTDWG--ENP-KIE 494

  Fly  2030 RVDMNGQ-NPIVVFQEFAHPESLAVDTEKKMVYYSASNPAVIGVMDYNGDDHTLILMKDSHPMAK 2093
            ..:::|| ..::|......|..||:|.::..:|:..:....|.|::.:|.... .|::|.    .
Human   495 CANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRR-TLLEDK----L 554

  Fly  2094 PRSLG--ILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSM-MIYKKRALMQHPCQTNN 2155
            |...|  :|...:|:.|.....|.|:....... ..|:|...||..: .:...:.:..:||...|
Human   555 PHIFGFTLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVNVAKVVGTNPCADRN 618

  Fly  2156 GGCKHLCIPGPGATRTCACGIGYRKENEI-NCVAYKIFAVVSQLDMIRGYSL-SDSSEAMVPISG 2218
            |||.|||...|.||| |.|.||....::: .|:..:.|.|.:....|...|| :::::..:|::|
Human   619 GGCSHLCFFTPHATR-CGCPIGLELLSDMKTCIVPEAFLVFTSRAAIHRISLETNNNDVAIPLTG 682

  Fly  2219 PGH-HILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGTDLQHVVKDGIGSNGIRGLTIDWVAGN 2282
            ... ..|..||  ....|||.:.:   ...|.|:..||:.::|||:.|:  :...|:.:||:..|
Human   683 VKEASALDFDV--SNNHIYWTDVS---LKTISRAFMNGSSVEHVVEFGL--DYPEGMAVDWMGKN 740

  Fly  2283 MYFTNVYPHENYVEVCWLDGSNRKVLVKTTTDAPRELAVNPIKRLLYWIDYGQHPRIGKALLDGS 2347
            :|:.:.  ..|.:||..|||..|:|||....|.||.||::|.|..:||.::|..|||.:|.:||:
Human   741 LYWADT--GTNRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGT 803

  Fly  2348 KWTPLVTSGISLPRDLTIDMQTHDIYWVDSKLDTIQKISYNGANRKIIRRDLPNPMGIAVYLNDV 2412
            ....||.. :....|||||.....:||.|...:.|:..:..|..|.:|..|||:|.|:..|.:.:
Human   804 NCMTLVDK-VGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSDYI 867

  Fly  2413 YWVDRNLMTVFKASKHSANETATSVRTNLEKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFS 2477
            ||.|.||.::.:|.| ::....|.::.:|:.:.||.::  ::..||..|.|.| .||.|.|||.:
Human   868 YWTDWNLHSIERADK-TSGRNRTLIQGHLDFVMDILVF--HSSRQDGLNDCMH-NNGQCGQLCLA 928

  Fly  2478 FPPDGGASGTSGGRNFRCECATG-KLSADERKCEVVNEYLVFATRTEI-RAVNLDPHSTEVPFTP 2540
            .|         ||.  ||.||:. .|....|.|.....:|:|:.::.| |.:..|.||.:: ..|
Human   929 IP---------GGH--RCGCASHYTLDPSSRNCSPPTTFLLFSQKSAISRMIPDDQHSPDL-ILP 981

  Fly  2541 LTNLTNVVGLDFDFAHNRMLYTQIRPWAKIAY---TKAN-KPGHDD-----ITVVLNKGINPE-- 2594
            |..|.||..:|:|            |..|..|   .:.| |...||     :...|::|.||:  
Human   982 LHGLRNVKAIDYD------------PLDKFIYWVDGRQNIKRAKDDGTQPFVLTSLSQGQNPDRQ 1034

  Fly  2595 --GIAYDWTQQKIYWTDSSNNSIYAMNLDGSELVMIARVER--PRAIVLDPCNGTLFFTDWGRFG 2655
              .::.|...:.::||..:.|:|....|.|..:.::.|.:|  |||||::...|.|:||:..  .
Human  1035 PHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQ--D 1097

  Fly  2656 TSGKIFRTTMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAAT 2720
            .:.||.|..:.|:.:..:....|.:|..|.:|....:|:|.||..::||..||.|.||..|..|.
Human  1098 RAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANRLTLEDAN 1162

  Fly  2721 I-YPFAITVFRNYIYWTDLQLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSSDRQKCNVNPCR 2784
            | .|..:|:...::||.|.|.:.:.|.||.||.....:..|:........:.....::.:.:||.
Human  1163 IVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCA 1227

  Fly  2785 INNGGCAQSCHPAPNGKAECKCDDSTKVVNEGRMCAPRNNTCEASKFYCKNGR--CISRMWSCDG 2847
            .:||||:..|....:|...|.|.....::.....|. ...||...:|.|..|.  ||...|.|||
Human  1228 RDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCG-EPPTCSPDQFACATGEIDCIPGAWRCDG 1291

  Fly  2848 DDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFKSWKCDHENDCKDGSDELGCVYPPCVDGEFT 2912
            ..:|.|.|||:.  |..  ||..:|.|..|:|:....:||.|.||:|.|||..| ...|:..:|.
Human  1292 FPECDDQSDEEG--CPV--CSAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC-DAICLPNQFR 1351

  Fly  2913 CANGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPANHLKCEKTNICVEPYWLCDGDNDCG 2977
            ||:|:|:...|.|:...||.|.  |||               |.||.|.                
Human  1352 CASGQCVLIKQQCDSFPDCIDG--SDE---------------LMCEITK---------------- 1383

  Fly  2978 DNSDEDPLH 2986
            ..||:.|.|
Human  1384 PPSDDSPAH 1392

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_572563.3 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:469594
YncE <492..634 CDD:442618
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:464251
YvrE 854..>992 CDD:442613
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:395011
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1522..1553 CDD:464251 4/30 (13%)
LY 1625..1665 CDD:214531 18/39 (46%)
LY 1667..1711 CDD:214531 22/43 (51%)
Ldl_recept_b 1690..1729 CDD:459654 25/38 (66%)
LY 1712..1754 CDD:214531 19/41 (46%)
LY 1986..2037 CDD:214531 18/51 (35%)
FXa_inhibition 2151..>2179 CDD:464251 16/27 (59%)
LY 2259..2305 CDD:214531 15/45 (33%)
Ldl_recept_b 2326..2366 CDD:459654 14/39 (36%)
LY 2352..2392 CDD:214531 12/39 (31%)
NHL 2579..>2711 CDD:302697 40/142 (28%)
NHL repeat 2593..2622 CDD:271320 7/32 (22%)
NHL repeat 2634..2678 CDD:271320 13/43 (30%)
LY 2671..2713 CDD:214531 13/41 (32%)
LDLa 2867..2901 CDD:238060 15/33 (45%)
LDLa 2906..2941 CDD:238060 14/34 (41%)
LDLa 2950..2983 CDD:238060 6/32 (19%)
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
FXa_inhibition 3259..3287 CDD:464251
FXa_inhibition 3293..3329 CDD:464251
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
Ldl_recept_b 3468..3511 CDD:459654
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:464251
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4391 CDD:459654
LY 4374..4417 CDD:214531
NHL repeat 4376..4422 CDD:271320
LRP5XP_011543331.1 YncE 34..223 CDD:442618 69/190 (36%)
LY 111..151 CDD:214531 18/39 (46%)
Ldl_recept_b 172..212 CDD:459654 26/41 (63%)
LY 196..238 CDD:214531 19/41 (46%)
LY 239..273 CDD:214531 16/35 (46%)
FXa_inhibition 308..345 CDD:464251 18/37 (49%)
LY 375..415 CDD:214531 9/43 (21%)
LY 417..459 CDD:214531 16/47 (34%)
LY 460..503 CDD:214531 17/50 (34%)
LY 504..546 CDD:214531 9/41 (22%)
LY 547..580 CDD:214531 8/37 (22%)
FXa_inhibition 614..649 CDD:464251 16/35 (46%)
NHL 694..887 CDD:302697 69/201 (34%)
LY 719..761 CDD:214531 15/45 (33%)
NHL repeat 729..765 CDD:271320 13/37 (35%)
LY 762..805 CDD:214531 19/42 (45%)
NHL repeat 772..811 CDD:271320 17/38 (45%)
NHL repeat 856..880 CDD:271320 8/23 (35%)
FXa_inhibition 915..950 CDD:464251 17/46 (37%)
LY 979..1018 CDD:214531 14/50 (28%)
LY 1069..1112 CDD:214531 15/44 (34%)
LY 1113..1155 CDD:214531 13/41 (32%)
FXa_inhibition 1226..1262 CDD:464251 9/35 (26%)
Ldl_recept_a 1267..1304 CDD:395011 16/38 (42%)
LDLa 1307..1341 CDD:238060 15/33 (45%)
LDLa 1345..1379 CDD:238060 15/50 (30%)
Blue background indicates that the domain is not in the aligned region.

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