DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mgl and LRP4

DIOPT Version :9

Sequence 1:	NP_001096924.2	Gene:	mgl / 8674055	FlyBaseID:	FBgn0261260	Length:	4769	Species:	Drosophila melanogaster
Sequence 2:	NP_002325.2	Gene:	LRP4 / 4038	HGNCID:	6696	Length:	1905	Species:	Homo sapiens

Alignment Length:	1746	Identity:	573/1746 - (32%)
Similarity:	890/1746 - (50%)	Gaps:	169/1746 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1141 AEPPVQPCPNSWDFTC-----NNQRCIPKSWLCDGDDDCLDNSDEEQNCTKPTCGSNEFQCRSGR 1200
            |..|...|..| .|||     ....|||..|.||||:||.|:|||: .|..|||...:|.|.:|:
Human    20 ASSPECACGRS-HFTCAVSALGECTCIPAQWQCDGDNDCGDHSDED-GCILPTCSPLDFHCDNGK 82

  Fly  1201 CIPQNFRCDQENDCGDNSDEQECGNVTCGTSQFACANGRCIPNMWKCDSENDCGDSSDEGDFCAE 1265
            ||.:::.||.:|||.|:||||:|....|...:|.|.||.||.::|.||.:|||||:|||.  |..
Human    83 CIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ--CDM 145

  Fly  1266 KTCAYFQFTCPRTGHCIPQSWVCDGDDDCFDKQDEKDCPPI----SCLANQFKCADLRQCVEESY 1326
            :.|:..:|.| ..|.||.:.|.||||.||.|..||::||..    .|...:|:|| ..:|:.:.|
Human   146 RKCSDKEFRC-SDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPCNLEEFQCA-YGRCILDIY 208

  Fly  1327 KCDGIPDCNDGSDEVGCPSMGPNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSDHSDEQDCGQIT 1391
            .|||..||.|.|||..|.|..|  |. ...|.|.| |.||...|.|||..||.|.|||::|....
Human   209 HCDGDDDCGDWSDESDCSSHQP--CR-SGEFMCDS-GLCINAGWRCDGDADCDDQSDERNCTTSM 269

  Fly  1392 CAQNFFKCNNTNCVFKAYICDGKDDCGDNSD-EGAEHACVPPPFKCPHGQWQCPGVSERCVNITS 1455
            |....|:|::..||..::.|||:|||.|||| |..|:...|   :|...|:.|  .:.||:....
Human   270 CTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENCENTGSP---QCALDQFLC--WNGRCIGQRK 329

  Fly  1456 VCDDTPDCPNGSDEG--EGC----DLAECEHQAGQCSSFCQKTPNGALCVCPPGSEIGEDGYTCI 1514
            :|:...||.:.|||.  :.|    ....|....|.|:..||.......|.|..|..:.|||:||.
Human   330 LCNGVNDCGDNSDESPQQNCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQ 394

  Fly  1515 DSNECDPPGLCSQQCTNTKGSYFCSCTDGYVLEPNKHTCKAVNHTAAFLIISNR----------- 1568
            |.|||...|.|||.|||::|::.|.|..||.|.|::.:|||:. ....|:.:||
Human   395 DVNECAEEGYCSQGCTNSEGAFQCWCETGYELRPDRRSCKALG-PEPVLLFANRIDIRQVLPHRS 458

  Fly  1569 -HSILVADLKEQGLERVPIIVENVVATASNMHTGTIFWSDMKLKKISRLD-RGMEPQEIINTGLD 1631
             :::|:.:|            ||.:|...:.....:||||:.|.:|.|.: .|...:|:::|||:
Human   459 EYTLLLNNL------------ENAIALDFHHRRELVFWSDVTLDRILRANLNGSNVEEVVSTGLE 511

  Fly  1632 LVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVRENITQPRGMCIDPSPGARWIFWTDWG 1696
            ...|||.||:...|||.||..:.|||:..:|::|.||:.:|:.:||.:.:.|..|.  |:|||||
Human   512 SPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGT--IYWTDWG 574

  Fly  1697 ENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRVYFADSKLDFIDFCYYNGTGRQQVLASS 1761
            ..||:|...|||:.|:.|.:|.::||||||:|.|.:|:|:.|:|...|:....:|:.|:.|:  |
Human   575 NTPRIEASSMDGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVI--S 637

  Fly  1762 HYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPC 1826
            ..|.||.::::|||:|||||.....:.|||||.||||.::.:.:..|:.||..|...||...|.|
Human   638 QGLPHPFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRC 702

  Fly  1827 AGSR--CQHLCLLSPSAPEGYSCKCRPGFKLLSEGRCIEEENPFLMVVKGTQIVDLPLNGGDARA 1889
            ..:.  |.||||  ||. :.|:|.|..||:.:|...|.:..:.||:..:...|..:..:..|. :
Human   703 GDNNGGCTHLCL--PSG-QNYTCACPTGFRKISSHACAQSLDKFLLFARRMDIRRISFDTEDL-S 763

  Fly  1890 GALAPVIGIESSTGLDFDRKGETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGIENGIVGAPYT 1954
            ..:.|:..:.|:..||:|.:.:.:||.....|     ||....:.|..:.:   :.:..:.:|..
Human   764 DDVIPLADVRSAVALDWDSRDDHVYWTDVSTD-----TISRAKWDGTGQEV---VVDTSLESPAG 820

  Fly  1955 IAFDWLGRNLYIGNRVASNIEAVRVDGKQKYRTIILANDGYPNSVSRPKQIALDPTEGKLFWIDE 2019
            :|.||:...||..:.....||....||..  ||:::.     .::.||:.|.::|..|.::|.|.
Human   821 LAIDWVTNKLYWTDAGTDRIEVANTDGSM--RTVLIW-----ENLDRPRDIVVEPMGGYMYWTDW 878

  Fly  2020 GVLEVPIKIGRVDMNGQ-NPIVVFQEFAHPESLAVDTEKKMVYYSASNPAVIGVMDYNGDDHTLI 2083
            |...   ||.|..|:.. ..:::......|..||:|...:.:|::.:....|.....:|....::
Human   879 GASP---KIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFAGLDGSKRKVL 940

  Fly  2084 LMKDSHPMAKPRSLGILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSMMIY-KKRALM 2147
            :   ...:..|..|.:...|:|:.|...:.|...|...|.:.:|:.:|..:|..:.:: ::|..:
Human   941 I---GSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLENLMDIHVFHRRRPPV 1002

  Fly  2148 QHPCQTNNGGCKHLCIPGP---GATRTCACGIGYRKENEINCVAYKIFAVVSQLDMIRGYSLSDS 2209
            ..||...||||.|||:..|   |.:.||..||....:.:........|.:.::...||..||...
Human  1003 STPCAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTCSPGMNSFLIFARRIDIRMVSLDIP 1067

  Fly  2210 --SEAMVPISGPGHHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGTDLQHVVKDGIGSNGIR 2272
              ::.:|||:....:.:.:.|..:|..:||::   ...:.|.|:..:|:..:.::..|:.:..
Human  1068 YFADVVVPINITMKNTIAIGVDPQEGKVYWSD---STLHRISRANLDGSQHEDIITTGLQTTD-- 1127

  Fly  2273 GLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTDAPRELAVNPIKRLLYWIDYGQHP 2337
            ||.:|.:...:|:|:.  ..|.:||..||||.|||||....|:||.:.:......:||.|:|::.
Human  1128 GLAVDAIGRKVYWTDT--GTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENA 1190

  Fly  2338 RIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHDIYWVDSKLDTIQKISYNGANRKIIRRDLPNP 2402
            ::.::.:|||....|:.:.:..|..||:|..:..:.|.|:..:.|:....|||||..:...:.:|
Human  1191 KLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQHP 1255

  Fly  2403 MGIAVYLNDVYWVDRNLMTVFKASKHSANETATSVRTNLEKLRDIAIYNINNQPQDDTNPCAHLG 2467
            .|:.:..:.:||.|....::.:|.|.:.:.... ||:||..|.|:       |..|...|   ||
Human  1256 YGLTLLDSYIYWTDWQTRSIHRADKGTGSNVIL-VRSNLPGLMDM-------QAVDRAQP---LG 1309

  Fly  2468 -------NGGCDQLCFSFPPDGGASGTSGGRNFRCECATG-KLSADERKCEVVNE-YLVFATRTE 2523
                   ||||..||...|        ||   |.|.|.|| :|..|.:.|:...| ||:|::|..
Human  1310 FNKCGSRNGGCSHLCLPRP--------SG---FSCACPTGIQLKGDGKTCDPSPETYLLFSSRGS 1363

  Fly  2524 IRAVNLDPHSTEVPFTPLTNLTNVVGLDFDFAHNRMLYTQ-----IRPWAKIAYTKANKPGHDDI 2583
            ||.::||.........|:..|.||:.||:|....::.||.     ||        :|:..| .::
Human  1364 IRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIR--------RADLNG-SNM 1419

  Fly  2584 TVVLNKGI-NPEGIAYDWTQQKIYWTDSSNNSIYAMNLDGS--ELVMIARVERPRAIVLDPCNGT 2645
            ..|:.:|: ..:|:|.||..:.:||||:..|:|.|..||||  ::::...::.||||.:.|..|.
Human  1420 ETVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDEPRAIAVFPRKGY 1484

  Fly  2646 LFFTDWGRFGTSGKIFRTTMAGSLKRAIVDKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDG 2710
            ||:||||..   .||.|..:.||.::.:::.||..|:||.:|||.||:||.||..::||.:||:|
Human  1485 LFWTDWGHI---AKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWVDAHLDRIESADLNG 1546

  Fly  2711 QNRELLVAATIYPFAITVFRNYIYWTDLQLRGVYRAEKHTGANMVEMVKRLEDSPRDIRIYSSDR 2775
            :.|::||:...:|||:|....:|||||.|.:.:.|.:|::|.|...::..:| ...||.:.|..|
Human  1547 KLRQVLVSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRNKETVLANVE-GLMDIIVVSPQR 1610

  Fly  2776 QKCNVNPCRINNGGCAQSCHPAPNGKAECKCDDSTKVVNEGRMC---------APR 2822
            | ...|.|.:|||||...|. |......|.|.|..    :.|.|         |||
Human  1611 Q-TGTNACGVNNGGCTHLCF-ARASDFVCACPDEP----DSRPCSLVPGLVPPAPR 1660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mgl	NP_001096924.2	LDLa	157..189	CDD:238060
		LDLa	204..236	CDD:238060
		LDLa	292..327	CDD:238060
		LDLa	332..366	CDD:238060
		LDLa	371..412	CDD:238060
		vWFA	<447..488	CDD:294047
		NHL	573..>716	CDD:302697
		NHL repeat	573..610	CDD:271320
		NHL repeat	616..654	CDD:271320
		NHL repeat	657..693	CDD:271320
		FXa_inhibition	763..805	CDD:291342
		LY	922..964	CDD:214531
		LY	973..1007	CDD:214531
		Ldl_recept_a	1188..1223	CDD:278486	17/34 (50%)
		LDLa	1227..1259	CDD:197566	16/31 (52%)
		LDLa	1268..1303	CDD:238060	16/34 (47%)
		LDLa	1308..1343	CDD:238060	15/34 (44%)
		LDLa	1356..1387	CDD:238060	16/30 (53%)
		LDLa	1391..1423	CDD:197566	15/32 (47%)
		LDLa	1435..1469	CDD:197566	9/33 (27%)
		FXa_inhibition	1478..1513	CDD:291342	11/34 (32%)
		FXa_inhibition	1522..1553	CDD:291342	14/30 (47%)
		LY	1625..1665	CDD:214531	17/39 (44%)
		LY	1667..1711	CDD:214531	19/43 (44%)
		Ldl_recept_b	1690..1728	CDD:278487	21/37 (57%)
		LY	1712..1754	CDD:214531	16/41 (39%)
		LY	1986..2037	CDD:214531	14/51 (27%)
		FXa_inhibition	2151..>2179	CDD:291342	14/30 (47%)
		LY	2259..2305	CDD:214531	13/45 (29%)
		Ldl_recept_b	2326..2366	CDD:278487	11/39 (28%)
		LY	2352..2392	CDD:214531	11/39 (28%)
		NHL	2579..>2711	CDD:302697	53/134 (40%)
		NHL repeat	2593..2622	CDD:271320	12/28 (43%)
		NHL repeat	2634..2678	CDD:271320	17/43 (40%)
		LY	2671..2713	CDD:214531	19/41 (46%)
		LDLa	2867..2901	CDD:238060
		LDLa	2906..2941	CDD:238060
		LDLa	2950..2983	CDD:238060
		LDLa	3034..3066	CDD:197566
		LDLa	3080..3115	CDD:197566
		LDLa	3128..3159	CDD:238060
		LDLa	3170..3204	CDD:238060
		LDLa	3210..3242	CDD:197566
		cEGF	3269..3292	CDD:289433
		vWFA	<3284..3324	CDD:294047
		LY	3362..3394	CDD:214531
		LY	3406..3448	CDD:214531
		LY	3498..3536	CDD:214531
		LY	3536..3578	CDD:214531
		FXa_inhibition	3607..3659	CDD:291342
		LDLa	3663..3696	CDD:238060
		LDLa	3705..3739	CDD:238060
		LDLa	3743..3775	CDD:197566
		LDLa	3784..3817	CDD:197566
		LDLa	3827..3861	CDD:197566
		LDLa	3871..3901	CDD:197566
		LDLa	3913..3947	CDD:238060
		LDLa	3952..3986	CDD:238060
		LDLa	3996..4027	CDD:197566
		LDLa	4043..4071	CDD:238060
		LDLa	4086..4117	CDD:238060
		EGF_CA	4163..4194	CDD:214542
		NHL	4276..>4426	CDD:302697
		NHL repeat	4291..4336	CDD:271320
Ldl_recept_b	4350..4390	CDD:278487
NHL repeat	4376..4422	CDD:271320
LRP4	NP_002325.2	LDLa	27..66	CDD:238060	19/40 (48%)
		Ldl_recept_a	70..105	CDD:278486	17/34 (50%)
		LDLa	110..142	CDD:238060	17/31 (55%)
		LDLa	148..182	CDD:238060	16/34 (47%)
		LDLa	231..265	CDD:238060	17/35 (49%)
		LDLa	270..304	CDD:238060	16/33 (48%)
		LDLa	311..343	CDD:197566	9/33 (27%)
		FXa_inhibition	358..393	CDD:291342	11/34 (32%)
		EGF_CA	395..434	CDD:214542	18/38 (47%)
		NHL	<471..622	CDD:302697	62/152 (41%)
		NHL repeat	471..507	CDD:271320	10/35 (29%)
		LDL-receptor class B 1	480..522		17/41 (41%)
		LY	505..545	CDD:214531	17/39 (44%)
		NHL repeat	510..550	CDD:271320	18/39 (46%)
		LDL-receptor class B 2	523..565		16/41 (39%)
		NHL repeat	555..589	CDD:271320	16/35 (46%)
		LDL-receptor class B 3	566..609		23/44 (52%)
		LY	590..632	CDD:214531	16/41 (39%)
		NHL repeat	598..622	CDD:271320	12/23 (52%)
		LDL-receptor class B 4	610..652		14/43 (33%)
		LY	633..673	CDD:214531	19/41 (46%)
		LDL-receptor class B 5	653..693		18/39 (46%)
		FXa_inhibition	702..>729	CDD:291342	12/29 (41%)
		LY	766..806	CDD:214531	11/44 (25%)
		LDL-receptor class B 6	785..827		10/49 (20%)
		LY	808..850	CDD:214531	10/46 (22%)
		LDL-receptor class B 7	828..870		12/48 (25%)
		LDL-receptor class B 8	871..914		12/45 (27%)
		Ldl_recept_b	871..911	CDD:278487	11/42 (26%)
		LY	895..937	CDD:214531	7/41 (17%)
		LDL-receptor class B 9	915..956		5/43 (12%)
		LY	938..979	CDD:214531	8/43 (19%)
		LDL-receptor class B 10	957..998		9/40 (23%)
		FXa_inhibition	1006..1043	CDD:291342	14/36 (39%)
		NHL	<1085..1277	CDD:302697	53/198 (27%)
		NHL repeat	1085..1123	CDD:271320	7/40 (18%)
		LDL-receptor class B 11	1093..1135		9/46 (20%)
		NHL repeat	1128..1161	CDD:271320	14/34 (41%)
		LDL-receptor class B 12	1136..1178		17/43 (40%)
		NHL repeat	1166..1203	CDD:271320	10/36 (28%)
		LDL-receptor class B 13	1179..1222		12/42 (29%)
		Ldl_recept_b	1179..1219	CDD:278487	11/39 (28%)
		NHL repeat	1212..1244	CDD:271320	9/31 (29%)
		LDL-receptor class B 14	1223..1263		10/39 (26%)
		NHL repeat	1253..1277	CDD:271320	5/23 (22%)
		LDL-receptor class B 15	1264..1306		13/49 (27%)
		FXa_inhibition	1313..1348	CDD:291342	16/45 (36%)
		LY	1379..1418	CDD:214531	13/47 (28%)
		LDL-receptor class B 16	1397..1439		12/50 (24%)
		LY	1420..1460	CDD:214531	15/39 (38%)
		LDL-receptor class B 17	1440..1482		16/41 (39%)
		LDL-receptor class B 18	1483..1526		19/45 (42%)
		Ldl_recept_b	1483..1523	CDD:278487	17/42 (40%)
		LY	1507..1547	CDD:214531	18/39 (46%)
		LDL-receptor class B 19	1527..1568		18/40 (45%)
		LY	1549..1589	CDD:214531	16/39 (41%)
		LDL-receptor class B 20	1569..1610		14/41 (34%)
		FXa_inhibition	1617..>1641	CDD:291342	10/24 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1659..1686		2/2 (100%)
		Endocytosis signal. /evidence=ECO:0000255	1766..1769
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1852..1905
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.710