DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment mgl and LRP1

DIOPT Version :9

Sequence 1:	NP_001096924.2	Gene:	mgl / 8674055	FlyBaseID:	FBgn0261260	Length:	4769	Species:	Drosophila melanogaster
Sequence 2:	XP_016874792.1	Gene:	LRP1 / 4035	HGNCID:	6692	Length:	4561	Species:	Homo sapiens

Alignment Length:	4480	Identity:	1633/4480 - (36%)
Similarity:	2323/4480 - (51%)	Gaps:	497/4480 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   332 CHHAQFRCTNAL-CIPYNFHCDGYHDCADKSDEA-----NCTAIACPDNKHLCPRGGASGTPKCI 390
            |...||.|.:.: ||...:.|||..||.|.||||     ...|..|..|:|.|     .||..|:
Human    27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNC-----LGTELCV 86

  Fly   391 LKSQLCDGKRDCEDGSDEETNCS--IASCPALSCEFKCGPSLTGGVCYCKPGQSLAPDNRTCVDL 453
            ..|:||:|.:||.|||||..:|.  ..:|..|.|:..|.|:|.|..|||.....|..|.:||.|.
Human    87 PMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDF 151

  Fly   454 DECAEWGHCDQLCTNTLGSYTCQCAQGYTLINDSK-CIA---PDANNLQLIFAHDRAIMRMLPHG 514
            |||:.:|.|.||||||.||:.|.|.:||.|..|:: |.|   |......|:.|:.:.|:.....|
Human   152 DECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSG 216

  Fly   515 SE-----PKILANATAAAGVTFHYARNTLYWSDIKTRKVQSLPLDAQNKAVSPFDQTLPGTWAPV 574
            ::     |......||   :.|.||..|:.|..:.....|:     |.|..     .:||....|
Human   217 AQVSTITPTSTRQTTA---MDFSYANETVCWVHVGDSAAQT-----QLKCA-----RMPGLKGFV 268

  Fly   575 ---------------ALAVDWVGDKIYVADLVGQKIDVFELSGQWHAVVLGSNLTSPADLALDPT 624
                           .:|:||:....|..|.:..:|.|...:|.....:|...|.:|..:||||.
Human   269 DEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPA 333

  Fly   625 AGLMFVADGGQ---VLRAHMDGTHARSIVSEAAYKASGVTVDIISKRVFWCDSLLDYIESVDYEG 686
            .|.:|..|.||   |.|..|||.:...:|........|:|:|::|:.|:|.|:.|||||.|||||
Human   334 MGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEG 398

  Fly   687 AHRVMVLRGQQVPSPSRLALFENRIYWTDA------TKQGIMSVDKFEGPTSIQVTYKAKDIREP 745
            ..|..:::|..:.....|.:|||.:|.|::      .|..::.|::|.. |..||.     .|..
Human   399 KGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRVNRFNS-TEYQVV-----TRVD 457

  Fly   746 KG--IIAVHALSQPRV-SNPCGNNN----GGCNHMCIVTAVKGAPTGLGFRCACSTGYQLETDLK 803
            ||  :...|...|||| |:.|.|:.    |||:.:|::.....|.|     |.|.:|:.|.:|.|
Human   458 KGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKART-----CRCRSGFSLGSDGK 517

  Fly   804 LC-KPVSE-FLMYSQQRFIKGKVLEPVIEGF-------SDAIMPV---VSRRARFVGLDFDARDE 856
            .| ||..| ||:|       ||....:|.|.       .:.::|:   ::.||    |||.|...
Human   518 SCKKPEHELFLVY-------GKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRA----LDFHAETG 571

  Fly   857 FIYYSDVLQDVIYRVHRNGTGREIVLASQNEGVEGLAVDWASKNLYYI-DSRKGTLNVLSTRNVT 920
            |||::|....:|.|...:||.||.:|......|||:||||...|||:. |..|.|::|.......
Human   572 FIYFADTTSYLIGRQKIDGTERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAA 636

  Fly   921 H-RRTLLK-NLKRPRAIVVHPNRGFIFFSEWD------RPANITRANTDGSGLLVF-KNVTLGWP 976
            . |:||:: .:..||||||.|..|::::::|:      |...:.||..|||...:| .:.|:.||
Human   637 QTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWP 701

  Fly   977 NGLSIDFKEDRVYWCDALLDHVQHANLDGTDIKTV-NSRLVRHPFSIVIHNDWMYITDWRLDAII 1040
            ||||:|....|:||.||..|.::...|:|||.|.| ....:.|.|.:..|.::::.|::|..::.
Human   702 NGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVY 766

  Fly  1041 RLHK-LTGEQEEMMVREPQTNRLYGVKVYSHEVQRIADTQPCHRNNGGCQKICFAVPIGASNGTD 1104
            ||.: :.|....:.:...:...::.:::|..:.|::. |..|..|||||..:|.|.|
Human   767 RLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVG-TNKCRVNNGGCSSLCLATP-------- 822

  Fly  1105 GVTTSSPSFGRLQSRCSCPYGERLADDQVSCIPDPSAEPPVQPCPNSWDFTCNNQRCIPKSWLCD 1169
                     |..|  |:|...:.|..|.|:|:.:||..||.|..|.  :|.|.|.|||.:.|.||
Human   823 ---------GSRQ--CACAEDQVLDADGVTCLANPSYVPPPQCQPG--EFACANSRCIQERWKCD 874

  Fly  1170 GDDDCLDNSDEEQN-CTKPTCGSNEFQCRSGRCIPQNFRCDQENDCGDNSDEQE--CGNVTCGTS 1231
            ||:||||||||... |.:.||.|:.|:|.:.||||..:.||.:||||::.||..  |...||..:
Human   875 GDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPN 939

  Fly  1232 QFACANGRCIPNMWKCDSENDCGDSSDEGDFCAEKTC-AYFQFTCPRTGHCIPQSWVCDGDDDCF 1295
            ||:||:|||||..|.||.::||||.|||...||..|| ...|||| ..|.||..:|.||.:.||.
Human   940 QFSCASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTC-NNGRCININWRCDNEKDCG 1003

  Fly  1296 DKQDEKDCP-PI---------------SCLANQFKCADLRQCVEESYKCDGIPDCNDGSDE--VG 1342
            |..||:.|| |.               ||.:.||||...| |:.|.:.|||..||.|.|||  ..
Human  1004 DGSDEQTCPEPADNDCGDNSDEAGCSHSCSSTQFKCNSGR-CIPEHWTCDGDNDCGDYSDETHAN 1067

  Fly  1343 CPSMG---PNQCNLEKHFRCKSTGFCIPIAWHCDGSNDCSDHSDEQDCGQIT--CAQNF-FKC-N 1400
            |.:..   |..|:.:: |:|:..|.|||:.|.|||..||.|.|||:.|..:|  |..:. |.| :
Human  1068 CTNQATRPPGGCHTDE-FQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHVCDPSVKFGCKD 1131

  Fly  1401 NTNCVFKAYICDGKDDCGDNSD-EGAEH-ACVPPPFKCPHGQWQCPGVSERCVNITSV------- 1456
            :..|:.||::|||.:||.|||| |..|. ||.||              |..|.|.|||
Human  1132 SARCISKAWVCDGDNDCEDNSDEENCESLACRPP--------------SHPCANNTSVCLPPDKL 1182

  Fly  1457 CDDTPDCPNGSDEGEGCDLAECEHQAGQCSSFCQKTP-NGALCVCPPGSEIGEDGYTCIDSNECD 1520
            ||...||.:||||||.||  :|....|.||..|...| .|.:|.||.|.|:|.|.:||...:.|.
Human  1183 CDGNDDCGDGSDEGELCD--QCSLNNGGCSHNCSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCA 1245

  Fly  1521 PPGLCSQQCTNTKGSYFCSCTDGYVLEPNKHTCKAVNHTAAFLIISNRHSILVADLKEQGLERVP 1585
            ....|||:|...|.|..|||.:|:||||:..:|::::....|:|.||||.|...||.:.....:.
Human  1246 KHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSLDPFKPFIIFSNRHEIRRIDLHKGDYSVLV 1310

  Fly  1586 IIVENVVATASNMHTGTIFWSDMKLKKISR---LDRG--MEPQEIINTGLDLVEGLAYDWIAQNL 1645
            ..:.|.:|...::....::|:|:...||.|   ||.|  ...:.:|..||...||||.||||.|:
Human  1311 PGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNI 1375

  Fly  1646 YWLDSKLNTIEVSAENGSNRLVLVRENITQPRGMCIDPSPGARWIFWTDWGEN-PRVERIGMDGT 1709
            ||::|.|:.|||:..:|:.|..|:..:|..||.:.:||..|.  :|||||..: ||:|...|.|.
Human  1376 YWVESNLDQIEVAKLDGTLRTTLLAGDIEHPRAIALDPRDGI--LFWTDWDASLPRIEAASMSGA 1438

  Fly  1710 MRKTIINT--KIYWPNGLTLDIATKRVYFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSL 1772
            .|:|:...  ...||||||:|...||:.:.|::.|.|....|:|:|..:||....:|.||.:::|
Human  1439 GRRTVHRETGSGGWPNGLTVDYLEKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTL 1503

  Fly  1773 FEDTLYWTDRQLNRVLSANKFRGKNQTVVSHLISQPLSIHVHHASLQPMTPNPCAGS----RCQH 1833
            :...:||||.:.|.:..|||:.|.|.|||....:||..:.|:|.|.|||.||||..:    .|.|
Human  1504 YGGEVYWTDWRTNTLAKANKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSH 1568

  Fly  1834 LCLLSPSAPEGYSCKCRPGFKLLSEGRCIEEENPFLMVVKGTQI--VDLPLNGGDARAGALAP-- 1894
            |||::.:  ...||.|....||..:.....|...||:..:..:|  |||.           ||
Human  1569 LCLINYN--RTVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLD-----------APYY 1620

  Fly  1895 -------VIGIESSTGLDFDRKGETLYWVQGREDDDENCTIYTTPYGGGNKTLFLGIENGIVGA- 1951
                   |..|::.|.||:|.:.:.:||...|....:...|..|           |:|. :|.|
Human  1621 NYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFINGT-----------GVET-VVSAD 1673

  Fly  1952 ---PYTIAFDWLGRNL----YIGNRVASNIEAVRVDGKQKYRTIILANDGYPNSVSRPKQIALDP 2009
               .:.:|.||:.|||    |..|:  ..|...|:||..|...:        ..:.:|..:.:.|
Human  1674 LPNAHGLAVDWVSRNLFWTSYDTNK--KQINVARLDGSFKNAVV--------QGLEQPHGLVVHP 1728

  Fly  2010 TEGKLFWIDEGVLEVPIKIGRVDMNGQNPIVVFQEFAHPESLAVDTEKKMVYYSASNPAVIGVMD 2074
            ..|||:|.|..      .|...:|:|.|..::|.....|..||:|..:..:|:.:|....|...:
Human  1729 LRGKLYWTDGD------NISMANMDGSNRTLLFSGQKGPVGLAIDFPESKLYWISSGNHTINRCN 1787

  Fly  2075 YNGDDHTLILMKDSHPMAKPRSLGILDHRLYYLDPLYERIVRIDLPHGDNPKTIVDNESDLRSMM 2139
            .:|....:|....|. :.|..:|.|:..:|::.|.:.|::.......|.....:.::.:.:..|.
Human  1788 LDGSGLEVIDAMRSQ-LGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMK 1851

  Fly  2140 IYKKRALMQH----PCQTNNGGCKHLCIPGPGATRTCACGIGYR-KENEINCVAYKIFAVVSQLD 2199
            :|.:...:.|    ||..|||.|..||:|....||:|.|..||. :..:..|.....|.:.|..:
Human  1852 VYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGSFLLYSVHE 1916

  Fly  2200 MIRGYSL--SDSSEAMVPISGPGHHILHVDVMYREQWIYWAEYNRGYWNGIFRSRPNGTDLQHVV 2262
            .|||..|  :|.|:|:||:||....: .:|.......|||.:..   .:.|.|::.:.|..:.||
Human  1917 GIRGIPLDPNDKSDALVPVSGTSLAV-GIDFHAENDTIYWVDMG---LSTISRAKRDQTWREDVV 1977

  Fly  2263 KDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYVEVCWLDGSNRKVLVKTTTDAPRELAVNPIKRL 2327
            .:|||.  :.|:.:||:|||:|:|:  ...:.:||..|:||.|.|::....|.||.:.|:|.|..
Human  1978 TNGIGR--VEGIAVDWIAGNIYWTD--QGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGY 2038

  Fly  2328 LYWIDYGQHPRIGKALLDGSKWTPLVTSGISLPRDLTIDMQTHDIYWVDSKLDTIQKISY-NGAN 2391
            |:|.::||:|||.::.|||::...||...||.|..:::|.|...:||.|::.|.|::|.. .|.|
Human  2039 LFWTEWGQYPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGEN 2103

  Fly  2392 RKII----RRDLPNPMGIAVYLNDVYWVDRNLM--TVFKASKHSANETATSVRTNL-EKLRDIAI 2449
            |:::    ..|:   ..::|:.:.:||.||...  ::.:.||.:|.: :..:||.: .:|:||.:
Human  2104 REVVLSSNNMDM---FSVSVFEDFIYWSDRTHANGSIKRGSKDNATD-SVPLRTGIGVQLKDIKV 2164

  Fly  2450 YNINNQPQDDTNPCAHLGNGGCDQLCFSFPPDGGASGTSGGRNFR-CECATGKLSADERKCEVVN 2513
            :  |...|..||.|| :.||||.|||.           ..||..| |.||.|.|:.|...|....
Human  2165 F--NRDRQKGTNVCA-VANGGCQQLCL-----------YRGRGQRACACAHGMLAEDGASCREYA 2215

  Fly  2514 EYLVFATRTEIRAVNL-DPHSTEVPFTPL---TNLTNVVGLDFDF-------AHNRMLYTQIRPW 2567
            .||:::.||.:::::| |..:...|..|.   .::.||:.|.||:       ..||:.::.|. :
Human  2216 GYLLYSERTILKSIHLSDERNLNAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIH-F 2279

  Fly  2568 AKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQQKIYWTDSSNNSIYAMNLDGSE-------- 2624
            ..|  .:.|..|...||:|.|.| :.||:||......:|||..:.::|....:|.:.
Human  2280 GNI--QQINDDGSRRITIVENVG-SVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERET 2341

  Fly  2625 LVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIVDKDLSQPSGLAIDYD 2689
            ::.::..:.|||.|||.|...:|:|:|.....|  |.|..::|:....:::||:..|:|||||:.
Human  2342 VITMSGDDHPRAFVLDECQNLMFWTNWNEQHPS--IMRAALSGANVLTLIEKDIRTPNGLAIDHR 2404

  Fly  2690 ERRLYWTDAVREKIERSDLDGQNR-ELLVAATIYPFAITVFRNYIYWTDLQLRGVYRAEKHTGAN 2753
            ..:||::||..:||||.:.||.:| .:|.:..::||.:.|:..:|:|||...|.|.||.||.|:|
Human  2405 AEKLYFSDATLDKIERCEYDGSHRYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSN 2469

  Fly  2754 MVEMVKRLEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGKAECKCDDSTKVVNEGRM 2818
            |..:...:...|..|...::|...|.::|||||||||...|.....|...|.|... :::.:...
Human  2470 MKLLRVDIPQQPMGIIAVANDTNSCELSPCRINNGGCQDLCLLTHQGHVNCSCRGG-RILQDDLT 2533

  Fly  2819 CAPRNNTCEA-SKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNNGRCIFK 2882
            |...|::|.| .:|.|.||.||:...:|||...|.|.|||.|:||....|.....:|:||||:..
Human  2534 CRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSN 2598

  Fly  2883 SWKCDHENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATSDETHERCPMN 2947
            ...|:..:||.|||||:.|....|..|||.|.:|.||..:..||...||:|  .|||      ||
Human  2599 MLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCED--ASDE------MN 2655

  Fly  2948 ---TTCPANHLK----------CEKTNICVEPYWLCDGDNDCGDNSDE-DPLHCGQRTCPTNSFR 2998
               |.| :::.:          ||:|::|..|.|:|||.|||||.||| |.....:..||.|.|.
Human  2656 CSATDC-SSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRCPLNYFA 2719

  Fly  2999 CPNHRCIPATWYCDGDDDCGDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDN 3063
            ||:.||||.:|.||.:|||..|.||  .:|   .:.|....|.|.|..||.:.::|||.:||.|.
Human  2720 CPSGRCIPMSWTCDKEDDCEHGEDE--THC---NKFCSEAQFECQNHRCISKQWLCDGSDDCGDG 2779

  Fly  3064 SDEDNRHQCNDRKCDEETEFTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQPC 3128
            |||  ...|..:.|. .:.|:|....     .|:|::|:||||.||.|||||:... .|.....|
Human  2780 SDE--AAHCEGKTCG-PSSFSCPGTH-----VCVPERWLCDGDKDCADGADESIAA-GCLYNSTC 2835

  Fly  3129 GEDMFTCGNGRCINKGWICDHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRN-QSRCDGE 3192
            .:..|.|.|.:||.|.::||||.||.||:||...|  :|.||...||.|.|.:|:.: |..||||
Human  2836 DDREFMCQNRQCIPKHFVCDHDRDCADGSDESPEC--EYPTCGPSEFRCANGRCLSSRQWECDGE 2898

  Fly  3193 DDCGDHSDEV----GCAKENITC-PQGQFACTNGQCIDYNLVCNKYPDCADESDEPAHCNVDECA 3252
            :||.|.|||.    .|..:...| ...||.|::|:|:...|:||...||.|.|||.. |:::||.
Human  2899 NDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERG-CHINECL 2962

  Fly  3253 KVEINQCGHKCVDTLTGYYCDCNEGYKLLADGKACADVDECLEQPGACSQHCSNTPGGFYCKCDE 3317
            ..:::.|...|.|...|:.|.|..|::|..||:.||||||| .....|||.|.||.|.:.|.|.|
Human  2963 SRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDEC-STTFPCSQRCINTHGSYKCLCVE 3026

  Fly  3318 TYYERQNDEHTCKRKDKIPPWLIFTNKYYVRNMSVDGHQYNLMHQDLMNVVALDFDIREEYMYFC 3382
            .|..|..|.|:||......|:|||.|:||:|.:::||..|.|:.|.|.|.||||||.||:.:|:.
Human  3027 GYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWT 3091

  Fly  3383 DVTAK-TIFRAKYGEADDEMPPEREAVIRHDSHGLEGIAIDWVGRKLYWLDRHSKNLDVSELDGS 3446
            |||.: ::.|..:....:.....|..:...|     |:|:||||..|||.|:....::||:|:|:
Human  3092 DVTTQGSMIRRMHLNGSNVQVLHRTGLSNPD-----GLAVDWVGGNLYWCDKGRDTIEVSKLNGA 3151

  Fly  3447 KRKTL-RSGVVDPRAIVVHPGIGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSID 3510
            .|..| .||:.:|||:||....||||:|.|...:.|.::|||||:.|.|::..  |.|||.|::|
Human  3152 YRTVLVSSGLREPRALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTK--ITWPNGLTLD 3214

  Fly  3511 YFTDRIYWADAHLDYIAYADLEGRHRHTVLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFH 3575
            |.|:|||||||..|||.:|.|:|.:||.||| ..:||:|||:||:||:||:||..|:|.||:|..
Human  3215 YVTERIYWADAREDYIEFASLDGSNRHVVLS-QDIPHIFALTLFEDYVYWTDWETKSINRAHKTT 3278

  Fly  3576 GANYTVLRNTTHRPYDLHINHPLRQLPYTN-PCGTNNGGCSHLCLIAPPPESTYLNIEGYIEEGA 3639
            |.|.|:|.:|.|||.|||:.|.|||....| ||..||||||:|||::|.        .|:
Human  3279 GTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPG--------GGH----- 3330

  Fly  3640 PIFKCACPNQFYLARDMKTCVANCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAPRH 3704
               |||||..|||..|.:|||:||||.|.:|  :::||||::||||.|.||.|.||||..|....
Human  3331 ---KCACPTNFYLGSDGRTCVSNCTASQFVC--KNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFK 3390

  Fly  3705 CRAGTFQCKNTNCTPSATICDGVDDCGDRSDEQNCDL-PCPLSDFKCKSSGRCILDSWRCDGDAD 3768
            ||.|.|||....||..|.||||.:||.|.|||.|||: .|..|.|||.::.|||...:||:|..:
Human  3391 CRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFRCNGQDN 3455

  Fly  3769 CKDGSDEDPAVCFKRTCDPKTEFSCK-NGRCIPQLWMCDFDNDCGDDSDEPAYMCRQRNCTTGWQ 3832
            |.||.||..  |.:.||.| .:|.|. ..||||::|:||.||||.|.||||| .|.|..|.....
Human  3456 CGDGEDERD--CPEVTCAP-NQFQCSITKRCIPRVWVCDRDNDCVDGSDEPA-NCTQMTCGVDEF 3516

  Fly  3833 RCPGQSNYRCIPKWLFCDGKDDCRDNSDELPENCPK--CNPETDFKCGNNRCIPKQWMCDFADDC 3895
            ||  :.:.||||....|||:|||.|.|||..|.|.:  |.| ..|:|.||||:|.:|.||:.:||
Human  3517 RC--KDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEP-YQFRCKNNRCVPGRWQCDYDNDC 3578

  Fly  3896 GDASDENEAVCKGRYRECSESEFRCGNGKCISSRWQCDHEDDCGDNSDEMHCEGYQCKNGTFQCA 3960
            ||.|||....    .|.||||||.|.||:||:.||:||.:.||.|.|||..|.. :|....|||.
Human  3579 GDNSDEESCT----PRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTP-RCDMDQFQCK 3638

  Fly  3961 SGHCIASYFRCDGDRDCRDMSDEVGCPPRFPGGRYCPESRFQCNNNLCVSLSDLCDGTDDCGDGS 4025
            |||||...:|||.|.||.|.|||..|.   .|.|.||...|||||.||..|:..|||.|||||.|
Human  3639 SGHCIPLRWRCDADADCMDGSDEEACG---TGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNS 3700

  Fly  4026 DEDPSVCSDFNCDTLRRFQCSNER-CVARYQICDGVDNCGDGSDENNMTLCASKQKPCDLYTQYQ 4089
            ||:|..|:.|.|...|.|:|.|:| |:...:.|||.||||||:||.:.....:....|....::.
Human  3701 DENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFL 3765

  Fly  4090 CANKHCIERSQVCDFSDDCGDASDELGC----HHTSSCSEANRGGCQQHCHNLTDGGYICTCYPG 4150
            |.|:.|:..|..|:..|||||.|||..|    ..||..:.|:..|.:..|.......| |.|..|
Human  3766 CRNQRCLSSSLRCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCVRTEKAAY-CACRSG 3829

  Fly  4151 YIIAADNKKKCSDVDECLTRQHTCSHQCHNLNGTYSCSCREGFHLTDGASGVCRAEKEDVILLFV 4215
            : .....:..|.|::||| |..|||..|:|..|.:.|||...|..|   ...|:||..:..:|::
Human  3830 F-HTVPGQPGCQDINECL-RFGTCSQLCNNTKGGHLCSCARNFMKT---HNTCKAEGSEYQVLYI 3889

  Fly  4216 -NGQEIRGL---NWHKSEEFAVIAAEK-RIEALDYDAQQQIVFWADSYDKTIKRSYMVNAID--- 4272
             :..|||.|   :.|.:.|.|....|. ||:|:|...:...|:|.:.:..||....:..|..
Human  3890 ADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWHTGTISYRSLPPAAPPTT 3954

  Fly  4273 ---GRAKI--GFAQDLNMKGGSKPTAVAVDWLASNLYWTEMDRTGSKPRGRVMVAKTDGRYRRSI 4332
               .|.:|  |... ||:.|...|..:|:||:|.|:|||:      ..|..:.||:..|..|:::
Human  3955 SNRHRRQIDRGVTH-LNISGLKMPRGIAIDWVAGNVYWTD------SGRDVIEVAQMKGENRKTL 4012

  Fly  4333 VNAGLEVPTSIAVNPQLGRIYWSDAGSAPKIEVSWMDGSKRRPLITEMIRHPAGLTIDYSQDHII 4397
            ::..::.|.:|.|:|..|.:||||.|:.||||.:.|||:.|..|:.:.|:.|.||.:||..:. :
Human  4013 ISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNER-L 4076

  Fly  4398 YWVDTKLNAIESMRADGSRRKAIVRGDQ---LRHPVSLDLFESNMFWMTRDTGELVRQDKFGRGV 4459
            ||.|.||:.|.|:|.:|:  ..||..|.   |.||.|:|:||..::.:|.....:.:..|||...
Human  4077 YWADAKLSVIGSIRLNGT--DPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSP 4139

  Fly  4460 QVVLHRYIVNPSGLKVYHDKRYNTSLPNPCDNSTCSHLCLLVPGGHRCACPD------------- 4511
            .|.|...:.:.|.:.:||..: ...:.||||...|..||||.|.|..|.||:
Human  4140 LVNLTGGLSHASDVVLYHQHK-QPEVTNPCDRKKCEWLCLLSPSGPVCTCPNGKRLDNGTCVPVP 4203

  Fly  4512 ASGPPPSHRSTAEVICNAAAEHPRPAPRICPCQNGGLCKEDAQGELLCECRTQFVGEHCE 4571
            :..|||              :.|||......|.|||.|..:|:.:..|.|:.::.|:.||
Human  4204 SPTPPP--------------DAPRPGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCE 4249

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mgl	NP_001096924.2	LDLa	157..189	CDD:238060
		LDLa	204..236	CDD:238060
		LDLa	292..327	CDD:238060
		LDLa	332..366	CDD:238060	16/39 (41%)
		LDLa	371..412	CDD:238060	18/40 (45%)
		vWFA	<447..488	CDD:294047	22/40 (55%)
		NHL	573..>716	CDD:302697	52/160 (33%)
		NHL repeat	573..610	CDD:271320	9/51 (18%)
		NHL repeat	616..654	CDD:271320	16/40 (40%)
		NHL repeat	657..693	CDD:271320	18/35 (51%)
		FXa_inhibition	763..805	CDD:291342	14/45 (31%)
		LY	922..964	CDD:214531	17/48 (35%)
		LY	973..1007	CDD:214531	15/33 (45%)
		Ldl_recept_a	1188..1223	CDD:278486	17/36 (47%)
		LDLa	1227..1259	CDD:197566	19/31 (61%)
		LDLa	1268..1303	CDD:238060	16/35 (46%)
		LDLa	1308..1343	CDD:238060	17/36 (47%)
		LDLa	1356..1387	CDD:238060	16/30 (53%)
		LDLa	1391..1423	CDD:197566	16/36 (44%)
		LDLa	1435..1469	CDD:197566	12/40 (30%)
		FXa_inhibition	1478..1513	CDD:291342	14/35 (40%)
		FXa_inhibition	1522..1553	CDD:291342	14/30 (47%)
		LY	1625..1665	CDD:214531	20/39 (51%)
		LY	1667..1711	CDD:214531	17/44 (39%)
		Ldl_recept_b	1690..1728	CDD:278487	18/40 (45%)
		LY	1712..1754	CDD:214531	15/43 (35%)
		LY	1986..2037	CDD:214531	10/50 (20%)
		FXa_inhibition	2151..>2179	CDD:291342	13/27 (48%)
		LY	2259..2305	CDD:214531	18/45 (40%)
		Ldl_recept_b	2326..2366	CDD:278487	15/39 (38%)
		LY	2352..2392	CDD:214531	14/40 (35%)
		NHL	2579..>2711	CDD:302697	46/139 (33%)
		NHL repeat	2593..2622	CDD:271320	8/28 (29%)
		NHL repeat	2634..2678	CDD:271320	15/43 (35%)
		LY	2671..2713	CDD:214531	18/41 (44%)
		LDLa	2867..2901	CDD:238060	14/33 (42%)
		LDLa	2906..2941	CDD:238060	16/34 (47%)
		LDLa	2950..2983	CDD:238060	18/43 (42%)
		LDLa	3034..3066	CDD:197566	13/31 (42%)
		LDLa	3080..3115	CDD:197566	14/34 (41%)
		LDLa	3128..3159	CDD:238060	15/30 (50%)
		LDLa	3170..3204	CDD:238060	17/38 (45%)
		LDLa	3210..3242	CDD:197566	13/32 (41%)
		cEGF	3269..3292	CDD:289433	11/22 (50%)
		vWFA	<3284..3324	CDD:294047	20/39 (51%)
		LY	3362..3394	CDD:214531	16/32 (50%)
		LY	3406..3448	CDD:214531	15/41 (37%)
		LY	3498..3536	CDD:214531	21/37 (57%)
		LY	3536..3578	CDD:214531	24/41 (59%)
		FXa_inhibition	3607..3659	CDD:291342	21/51 (41%)
		LDLa	3663..3696	CDD:238060	18/32 (56%)
		LDLa	3705..3739	CDD:238060	19/33 (58%)
		LDLa	3743..3775	CDD:197566	14/31 (45%)
		LDLa	3784..3817	CDD:197566	18/33 (55%)
		LDLa	3827..3861	CDD:197566	15/33 (45%)
		LDLa	3871..3901	CDD:197566	16/29 (55%)
		LDLa	3913..3947	CDD:238060	21/33 (64%)
		LDLa	3952..3986	CDD:238060	19/33 (58%)
		LDLa	3996..4027	CDD:197566	19/30 (63%)
		LDLa	4043..4071	CDD:238060	16/28 (57%)
		LDLa	4086..4117	CDD:238060	13/30 (43%)
		EGF_CA	4163..4194	CDD:214542	14/30 (47%)
		NHL	4276..>4426	CDD:302697	56/154 (36%)
		NHL repeat	4291..4336	CDD:271320	14/44 (32%)
Ldl_recept_b	4350..4390	CDD:278487	19/39 (49%)
NHL repeat	4376..4422	CDD:271320	17/45 (38%)
LRP1	XP_016874792.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	137	1.000	Domainoid score	I4897
eggNOG	1	0.900	-	-		E1_KOG1215
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1326at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100345
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.720