DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and LDLR

DIOPT Version :10

Sequence 1:NP_572563.3 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_000518.1 Gene:LDLR / 3949 HGNCID:6547 Length:860 Species:Homo sapiens


Alignment Length:858 Identity:285/858 - (33%)
Similarity:399/858 - (46%) Gaps:185/858 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly  2826 CEASKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNN--GRCIFKSWKCDH 2888
            ||.::|.|::|:|||..|.|||..:|.|.|||....|...:|...:|.|..  .|||.:.|:||.
Human    27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDG 91

  Fly  2889 ENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPAN 2953
            :.||.:||||.||....|...||.|.:|:||.:                                
Human    92 QVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISR-------------------------------- 124

  Fly  2954 HLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYCDGDDDCG 3018
                         .::||.|.||.|.|||  ..|...||...||:|.:..|||..|.||.|.||.
Human   125 -------------QFVCDSDRDCLDGSDE--ASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE 174

  Fly  3019 DGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNRHQCNDRKCDEETEF 3083
            ||:||.|..|:.                    :|:..||:.           .|:      ..||
Human   175 DGSDEWPQRCRG--------------------LYVFQGDSS-----------PCS------AFEF 202

  Fly  3084 TCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQPCGEDMFTCGNGRCINKGWICD 3148
            .|:.      .:||...|.|||.|||.|.:||    .|||.                        
Human   203 HCLS------GECIHSSWRCDGGPDCKDKSDE----ENCAV------------------------ 233

  Fly  3149 HDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRNQSRCDGEDDCGDHSDEVGCAKENITCPQ 3213
                               .||...||.|.:..||....:||.|.||.|.||||||.  |:|..:
Human   234 -------------------ATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCV--NVTLCE 277

  Fly  3214 G--QFACTNGQCIDYNLVCNKYPDCADESDEP-AHCNVDECAKVEIN-QCGHKCVDTLTGYYCDC 3274
            |  :|.|.:|:||..:.|||...||.|.|||| ..|..:||  ::.| .|.|.|.|...||.|.|
Human   278 GPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNEC--LDNNGGCSHVCNDLKIGYECLC 340

  Fly  3275 NEGYKLLADGKACADVDECLEQPGACSQHCSNTPGGFYCKCDETYYERQNDEHT--CKRKDKIPP 3337
            .:|::|:|. :.|.|:||| :.|..|||.|.|..||:.|:|:|.:   |.|.||  ||....| .
Human   341 PDGFQLVAQ-RRCEDIDEC-QDPDTCSQLCVNLEGGYKCQCEEGF---QLDPHTKACKAVGSI-A 399

  Fly  3338 WLIFTNKYYVRNMSVDGHQYNLMHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMP 3402
            :|.|||::.||.|::|..:|..:..:|.||||||.::....:|:.|::.:.|...:...|..  .
Human   400 YLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHG--V 462

  Fly  3403 PEREAVIRHDSHGLEGIAIDWVGRKLYWLDRHSKNLDVSELDGSKRKTL-RSGVVDPRAIVVHPG 3466
            ...:.||..|....:|:|:||:...:||.|.....:.|::..|.||||| |.....||||||.|.
Human   463 SSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPV 527

  Fly  3467 IGYLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADL 3531
            .|::|:|.|...|.|.|.|::|.:...::..|  |.|||.:::|..:.|:||.|:.|..|:..|:
Human   528 HGFMYWTDWGTPAKIKKGGLNGVDIYSLVTEN--IQWPNGITLDLLSGRLYWVDSKLHSISSIDV 590

  Fly  3532 EGRHRHTVLSGSK-VPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHIN 3595
            .|.:|.|:|...| :.|.|:|::|:|.::|:|...:||..||:..|::..:|......|.|:.:.
Human   591 NGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLF 655

  Fly  3596 HPLRQLPYTNPCGTN--------NGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQFYL 3652
            |.|     |.|.|.|        ||||.:|||.||           .|...:|.|.||||:...|
Human   656 HNL-----TQPRGVNWCERTTLSNGGCQYLCLPAP-----------QINPHSPKFTCACPDGMLL 704

  Fly  3653 ARDMKTCVANCTA 3665
            ||||::|:....|
Human   705 ARDMRSCLTEAEA 717

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_572563.3 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:469594
YncE <492..634 CDD:442618
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:464251
YvrE 854..>992 CDD:442613
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:395011
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1522..1553 CDD:464251
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1729 CDD:459654
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:464251
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:459654
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060 15/35 (43%)
LDLa 2906..2941 CDD:238060 7/34 (21%)
LDLa 2950..2983 CDD:238060 8/32 (25%)
LDLa 3034..3066 CDD:197566 3/31 (10%)
LDLa 3080..3115 CDD:197566 13/34 (38%)
LDLa 3128..3159 CDD:238060 0/30 (0%)
LDLa 3170..3204 CDD:238060 16/33 (48%)
LDLa 3210..3242 CDD:197566 14/33 (42%)
FXa_inhibition 3259..3287 CDD:464251 11/27 (41%)
FXa_inhibition 3293..3329 CDD:464251 16/37 (43%)
LY 3362..3394 CDD:214531 10/31 (32%)
LY 3406..3448 CDD:214531 12/41 (29%)
Ldl_recept_b 3468..3511 CDD:459654 14/42 (33%)
LY 3498..3536 CDD:214531 14/37 (38%)
LY 3536..3578 CDD:214531 16/42 (38%)
FXa_inhibition 3607..3659 CDD:464251 23/59 (39%)
LDLa 3663..3696 CDD:238060 1/3 (33%)
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4391 CDD:459654
LY 4374..4417 CDD:214531
NHL repeat 4376..4422 CDD:271320
LDLRNP_000518.1 Ldl_recept_a 25..58 CDD:395011 15/30 (50%)
Ldl_recept_a 66..104 CDD:395011 15/37 (41%)
Ldl_recept_a 107..143 CDD:395011 16/82 (20%)
Binding to Getah virus E1-E2 spike glycoproteins. /evidence=ECO:0000269|PubMed:38245515 146..233 41/133 (31%)
Ldl_recept_a 147..179 CDD:395011 16/31 (52%)
Ldl_recept_a 195..231 CDD:395011 16/62 (26%)
Ldl_recept_a 235..270 CDD:395011 17/34 (50%)
Ldl_recept_a 278..308 CDD:395011 13/29 (45%)
FXa_inhibition 318..>346 CDD:464251 11/29 (38%)
EGF_CA 354..388 CDD:214542 17/37 (46%)
LDL-receptor class B 1 397..438 17/41 (41%)
LY 419..457 CDD:214531 11/37 (30%)
LDL-receptor class B 2 439..485 11/47 (23%)
Ldl_recept_b 439..483 CDD:459654 9/45 (20%)
LDL-receptor class B 3 486..528 18/41 (44%)
Ldl_recept_b 487..526 CDD:459654 17/38 (45%)
LDL-receptor class B 4 529..572 15/44 (34%)
Ldl_recept_b 529..569 CDD:459654 14/41 (34%)
LY 553..595 CDD:214531 14/43 (33%)
LDL-receptor class B 5 573..615 15/41 (37%)
LDL-receptor class B 6 616..658 12/41 (29%)
Ldl_recept_b 616..656 CDD:459654 11/39 (28%)
FXa_inhibition 671..711 CDD:464251 21/50 (42%)
Clustered O-linked oligosaccharides 721..768
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 734..755
Required for MYLIP-triggered down-regulation of LDLR. /evidence=ECO:0000269|PubMed:19520913 811..860
NPXY motif. /evidence=ECO:0000269|PubMed:22509010 823..828
Blue background indicates that the domain is not in the aligned region.

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