DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and ldlra

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_001025454.1 Gene:ldlra / 387529 ZFINID:ZDB-GENE-031217-1 Length:911 Species:Danio rerio


Alignment Length:906 Identity:282/906 - (31%)
Similarity:401/906 - (44%) Gaps:228/906 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly  2825 TCEASKFYCKNGRCISRMWSCDGDDDCGDNSDEDPNYCAYHSCSPNEFRCNN--GRCIFKSWKCD 2887
            ||::.::.|.||:||:..|.||..|||||.:||.|..|...:|.|::|.|..  .:||.||||||
Zfish    23 TCDSRQYQCGNGKCITARWVCDETDDCGDGTDELPAACLAKTCRPSQFSCGGRLNQCIPKSWKCD 87

  Fly  2888 HENDCKDGSDELGCVYPPCVDGEFTCANGRCIPQAQVCNGVNDCKDNATSDETHERCPMNTTCPA 2952
            .:.||::.:||.||....|.||||.|.:|:|:..|                              
Zfish    88 GKADCENNADEEGCDPRQCHDGEFRCGSGQCVTAA------------------------------ 122

  Fly  2953 NHLKCEKTNICVEPYWLCDGDNDCGDNSDEDPLHCGQRTCPTNSFRCPNHRCIPATWYCDGDDDC 3017
                           ::||.:.||.|.|||  :.|...||.::|||                   
Zfish   123 ---------------FVCDDEIDCEDGSDE--VSCPPTTCGSSSFR------------------- 151

  Fly  3018 GDGADEPPDYCKSEGRTCFGDLFTCDNGNCIPRIYICDGDNDCLDNSDEDNRHQCNDRKCDEETE 3082
                                    |:|..|:||:::||||.||.|||||                
Zfish   152 ------------------------CNNAQCVPRLWVCDGDADCADNSDE---------------- 176

  Fly  3083 FTCVENKSWQRAQCIPKKWICDGDPDCVDGADENTTLHNCATQQPCGEDMFTCGNGRCINKGWIC 3147
                          :|:|        |..|..:       .|:.||....|.||:|.||:..|.|
Zfish   177 --------------LPEK--------CGPGTSK-------PTKNPCTSMEFHCGSGECIHGSWKC 212

  Fly  3148 DHDNDCGDGTDEGKFCNSKYKTCSAQEFTCQNFKCIRNQSRCDGEDDCGDHSDEVGCAKENITCP 3212
            |...||.|.:||.   |....||...||.|.:..||....:|:...||.|.|||:||.......|
Zfish   213 DGGADCLDHSDEQ---NCSLPTCRPDEFQCGDGSCIHGSRQCNHVYDCKDMSDELGCVNATHCEP 274

  Fly  3213 QGQFACTNGQCIDYNLVCNKYPDCADESDEP-AHCNVDECAKVEINQCGHKCVDTLTGYYCDCNE 3276
            ..:|.|.:|:||....||||..||.|.|||| ..|:.:||. .....|.|.|.|...||.|.|..
Zfish   275 PYRFKCRSGECISMEKVCNKQRDCRDWSDEPLRECDSNECL-YNNGGCSHICNDLKIGYECLCPT 338

  Fly  3277 GYKLLADGKACADVDECLEQPGACSQHCSNTPGGFYCKCDETYYERQND--EHTCKRKDKIPPWL 3339
            |::|: |.:.|.|:||| ..|..|||.|.|..|.:.|:|::.|   |.|  ...||....| .:|
Zfish   339 GFRLV-DKRRCEDIDEC-ANPDTCSQICVNQMGSYKCECEDGY---QMDPASKACKAIGTI-AYL 397

  Fly  3340 IFTNKYYVRNMSVDGHQYNLMHQDLMNVVALDFDIREEYMYFCDVTAKTIFRAKYGEADDEMPPE 3404
            .|||::.||.|::|..:|..:...|.||||||.:|....:|:.|::.|.|:              
Zfish   398 FFTNRHEVRKMTLDRSEYIRVIPRLKNVVALDMNIASRDIYWSDLSLKKIY-------------- 448

  Fly  3405 REAVIRHDSHGLEGIAIDWVGRKLYWLDRHSKNLDVSELDGSKRKTL-RSGVVDPRAIVVHPGIG 3468
                      .:.|.                  :.|:..|||:|||| :..:..||||||.|...
Zfish   449 ----------SIRGA------------------ISVATADGSRRKTLFKENLAKPRAIVVDPIKN 485

  Fly  3469 YLYFTSWHLQAYIAKMGMDGSNFSRILNWNDGIAWPNALSIDYFTDRIYWADAHLDYIAYADLEG 3533
            ::::|.|...|.|.|.|::|.:.|.::  .|.|.|||.:::|..|:|:||.|:.|..::...::|
Zfish   486 FMFWTDWGTPAKIEKSGLNGVDRSTLV--ADDIVWPNGITLDLLTERLYWVDSKLHTLSSISVQG 548

  Fly  3534 RHRHT-VLSGSKVPHVFALSLFDDYIYWSDWNLKAIVRANKFHGANYTVLRNTTHRPYDLHINHP 3597
            ..|.| ::...|:.|..:|::|::.::|:|.:..||:.||:..|.:.|.:......|.|:.:.|.
Zfish   549 DGRRTLIIDQGKLAHPLSLTVFEEKVFWTDVSNNAILSANRVTGGDITKVAEHLSSPEDIVLFHN 613

  Fly  3598 LRQLPYTNPCGTNNGGCSHLCLIAPPPESTYLNIEGYIEEGAPIFKCACPNQFYLARDMKTCV-A 3661
            |:|....|.|..|||||..|||.||           .|...:|.:.||||:...|||||:.|| |
Zfish   614 LKQPTGINWCRINNGGCEFLCLAAP-----------QINRFSPKYTCACPDNMMLARDMRKCVPA 667

  Fly  3662 NCTAGQHLCGGRDEKCIPWFWKCDGEKDCKDGSDEPATCAPRHCRAGTFQCKNTNCTPSAT 3722
            ..||...:   |.|  ||...:          ...|:...|:..|..|     ||..|..|
Zfish   668 VVTAATPV---RPE--IPTTIR----------PQVPSETTPKPARPST-----TNSQPLPT 708

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531
Ldl_recept_a 1188..1223 CDD:278486
LDLa 1227..1259 CDD:197566
LDLa 1268..1303 CDD:238060
LDLa 1308..1343 CDD:238060
LDLa 1356..1387 CDD:238060
LDLa 1391..1423 CDD:197566
LDLa 1435..1469 CDD:197566
FXa_inhibition 1478..1513 CDD:291342
FXa_inhibition 1522..1553 CDD:291342
LY 1625..1665 CDD:214531
LY 1667..1711 CDD:214531
Ldl_recept_b 1690..1728 CDD:278487
LY 1712..1754 CDD:214531
LY 1986..2037 CDD:214531
FXa_inhibition 2151..>2179 CDD:291342
LY 2259..2305 CDD:214531
Ldl_recept_b 2326..2366 CDD:278487
LY 2352..2392 CDD:214531
NHL 2579..>2711 CDD:302697
NHL repeat 2593..2622 CDD:271320
NHL repeat 2634..2678 CDD:271320
LY 2671..2713 CDD:214531
LDLa 2867..2901 CDD:238060 16/35 (46%)
LDLa 2906..2941 CDD:238060 9/34 (26%)
LDLa 2950..2983 CDD:238060 7/32 (22%)
LDLa 3034..3066 CDD:197566 14/31 (45%)
LDLa 3080..3115 CDD:197566 4/34 (12%)
LDLa 3128..3159 CDD:238060 13/30 (43%)
LDLa 3170..3204 CDD:238060 13/33 (39%)
LDLa 3210..3242 CDD:197566 14/31 (45%)
cEGF 3269..3292 CDD:289433 9/22 (41%)
vWFA <3284..3324 CDD:294047 15/39 (38%)
LY 3362..3394 CDD:214531 12/31 (39%)
LY 3406..3448 CDD:214531 5/41 (12%)
LY 3498..3536 CDD:214531 13/37 (35%)
LY 3536..3578 CDD:214531 13/42 (31%)
FXa_inhibition 3607..3659 CDD:291342 22/51 (43%)
LDLa 3663..3696 CDD:238060 6/32 (19%)
LDLa 3705..3739 CDD:238060 6/18 (33%)
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
ldlraNP_001025454.1 LDLa 23..55 CDD:197566 15/31 (48%)
Ldl_recept_a 63..101 CDD:365841 16/37 (43%)
LDLa 106..140 CDD:238060 17/80 (21%)
LDLa 144..176 CDD:197566 19/74 (26%)
Ldl_recept_a 192..227 CDD:365841 16/37 (43%)
Ldl_recept_a 231..266 CDD:365841 14/34 (41%)
LDLa 274..304 CDD:238060 14/29 (48%)
FXa_inhibition 314..348 CDD:373209 12/35 (34%)
EGF_CA 350..380 CDD:214542 14/33 (42%)
Ldl_recept_b 437..481 CDD:278487 18/85 (21%)
Ldl_recept_b 485..525 CDD:278487 13/41 (32%)
LY 510..551 CDD:214531 13/42 (31%)
Ldl_recept_b 572..611 CDD:278487 10/38 (26%)
FXa_inhibition 623..664 CDD:373209 22/51 (43%)
PHA03247 <666..808 CDD:223021 15/63 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.810

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