DRSC/TRiP Functional Genomics Resources

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Protein Alignment mgl and Lrp4

DIOPT Version :10

Sequence 1:NP_572563.3 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster


Alignment Length:1955 Identity:576/1955 - (29%)
Similarity:897/1955 - (45%) Gaps:278/1955 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   988 VYWCDALLDHVQHANLDGTDIKTVNSRLVRHPFSIVIHNDWMYITDWRLDAIIRLHKLTGEQEEM 1052
            |:.|..|.|      |..|.:|........||.:.:...||........||.|...:...|..|.
  Fly    15 VWLCLGLGD------LTKTAVKRNAPHYGIHPTNALGRWDWNKHKQLHSDARIGHLEAGNESRED 73

  Fly  1053 MVREPQT---NRLYGVKVYSHEVQRIADTQPCHRN-NGGCQKICFAVP----------------- 1096
            .:.|..:   .:|:.|..|....|...|:|..|.: .|....:..:||                 
  Fly    74 QLSEELSKFGEKLFPVSNYPPYQQNNEDSQEVHHSGEGRLHTMESSVPSKTRISGGTNSNDTPKF 138

  Fly  1097 --IGA-----------------SNGTDG------------------VTTSSPSF-GRLQSRCSCP 1123
              |||                 |.|.||                  :....||. |...|.|   
  Fly   139 RNIGAQRGRTEIAGIRETDRISSRGRDGFIGGPSNKQKPFRVNLAVLVQDDPSQPGETYSNC--- 200

  Fly  1124 YGERLADDQVSCIPDPSAEPPVQ----------PCPNSWDFTCNNQRCIPKSWLCDGDDDCLDNS 1178
              :...:...:|.|:..|.|.:|          .||.::       |||.|.|||||||||.|.|
  Fly   201 --QNSNESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTF-------RCISKYWLCDGDDDCGDYS 256

  Fly  1179 DEEQNCTKPTCGSNEFQCRSGRCIPQNFRCDQENDCGDNSDEQECGNVTCGTSQFACANGRCIPN 1243
            ||.....:..|..::|:|.:|.|||:.:.||.||||.|.|||..|...||....|.|.:|.||..
  Fly   257 DETHCGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCISL 321

  Fly  1244 MWKCDSENDCGDSSDEGDFCAE--KTCAYFQFTC---------PRTGHCIPQSWVCDGDDDCFDK 1297
            .::||.|:||.|:|||.. ||.  .:|...:|.|         | :|.||...:.||||:||.|.
  Fly   322 AFRCDGEHDCNDNSDELK-CAAVINSCPEGEFKCRGGLGGAGGP-SGQCILNRFRCDGDNDCGDW 384

  Fly  1298 QDEKDCP--PISCLANQFKCADLRQCVEESYKCDGIPDCNDGSDEVGCPSMGPNQCNLEKHFRCK 1360
            .||::||  |..|.:|::||||                                           
  Fly   385 SDEENCPQKPSLCTSNEYKCAD------------------------------------------- 406

  Fly  1361 STGFCIPIAWHCDGSNDCSDHSDEQDCGQ------ITCAQNFFKCNNTNCVFKAYICDGKDDCGD 1419
              |.|||..|.||...||....||.|||.      :||..:.|.|||..|:.|.::|||..||..
  Fly   407 --GTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDCAA 469

  Fly  1420 NSDEGAEHACVPPPFKCPHGQWQCPGVS-----ERCVNITSVCDDTPDCPNGSDEGEGCDLAECE 1479
            ..||...|      .:|..||:.||...     :.||:...:||...:||.|.||.:.....:|.
  Fly   470 GEDEVECH------LQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKERKCS 528

  Fly  1480 HQAGQCSSFCQKTPNGA-LCVCPPGSEIGEDGYTCIDSNECD--PPGLCSQQCTNTKGSYFCSCT 1541
             :...|...|.:|..|: .|.|..|..:.::...|.|.:||.  ...:|||:|.||.||:.|||.
  Fly   529 -EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCSCE 592

  Fly  1542 DGYVLEPNKHTCKAVNHTAAFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGTIFWS 1606
            .||:|.|:..:|||:. .|..|:::||..|....|.......:...:.|.:|...:...|.:|||
  Fly   593 TGYILRPDLRSCKALG-GAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMFWS 656

  Fly  1607 DMKLKKISRL-DRGMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVLVR 1670
            |:....|..: ..|...:::|..||:...|:|.|||...|:|.||....:|||...|:.|.|:..
  Fly   657 DVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVIAS 721

  Fly  1671 ENITQPRGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKRVY 1735
            .::.:||.:.:  .||....||:|||.||::||..||||.||.||:..:.|||||.:|....::|
  Fly   722 YDLDKPRAIVV--HPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSKIY 784

  Fly  1736 FADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGKNQTV 1800
            :||:|...|:....:|:.|.::|  |.:|.||.:|:|||||:||||.....|.:|:|..||....
  Fly   785 WADAKQHAIECSNLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEFRA 847

  Fly  1801 VSHLISQPLSIHVHHASLQPMTPNPCAGSR------CQHLCLLSPSAPEGYSCKCRPGFKLLSEG 1859
            |......|:.||.:|.:.||...:.|...|      |.||||.:.::..   |.|..|..|..:|
  Fly   848 VHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPNKTSRR---CGCPIGLSLKEDG 909

  Fly  1860 RCIEEENPFLMVV---KGTQIVDLPLNGGDAR-AGALAPVIGIESSTGLDFDRKGETLYWVQGRE 1920
            :..:.....|::|   |..::..|..|..|.. ...:.|:..::.:..||:....:.:||.    
  Fly   910 KTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWT---- 970

  Fly  1921 DDDENCTIYTTPYGGGNKTLFLG------IENGIVGAPYTIAFDWLGRNLYIGNRVASNIEAVRV 1979
             |.|..||        ||....|      :.:.:| :|..:|.||:...||..:...:.||....
  Fly   971 -DVERSTI--------NKAHLNGSYQQRVVHSNLV-SPVGLALDWITDKLYWTDPSTNRIEVATT 1025

  Fly  1980 DGKQKYRTIILANDGYPNSVSRPKQIALDPTEGKLFWIDEGVLEVPIKIGRVDMNGQNPI-VVFQ 2043
            :||.  ||:::....|     :|:.|.::|.||.:||.|.|  :.|: |.|.:|:|...: :..:
  Fly  1026 NGKM--RTLLIWEKLY-----KPRDIVVNPIEGFMFWSDWG--DDPM-IERANMDGHERVTITSK 1080

  Fly  2044 EFAHPESLAVDTEKKMVYYSASNPAVIGVMDYNGDDHTLILMKDSHPMAKPRSLGILDHRLYYLD 2108
            :..:|..||:|.||..:|:.......:..|:::|....:||....||.    .|.:.:.|:::.|
  Fly  1081 KLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVILNGLGHPF----GLDVNEGRVFWTD 1141

  Fly  2109 PLYERIVRIDLPHGDNPKTIVDNESDLRSMMIY-KKRALMQHPCQTNNGGCKHLCIPGPGATRTC 2172
            ...:.::..:...|.:...|:.|.:||..:.:: :.|..:.:.|...||||.|||:..| .:.||
  Fly  1142 WDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCLLNP-TSYTC 1205

  Fly  2173 ACGIGYR-KENEINC----VAYKIFAVVSQLDMIRGYSLSDSS--EAMVPISGPGHHILHVDVMY 2230
            ||.:|.: ||:...|    ..|.:||  .::| ||..||....  :.::|:. |..:.:.:||..
  Fly  1206 ACTVGVQLKEDRHTCSEGPTQYILFA--HRID-IRQISLDFDHLIDVVLPLP-PISNAVALDVDR 1266

  Fly  2231 REQWIYWAEYNRGYWNGIFRSRPNGTDLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHENYV 2295
            :..:|||::...   |.|..|.|:|..:|.:|.|.:.:..  ||.:|.:...:|:.:...|.  :
  Fly  1267 KTGYIYWSDTIE---NVIMSSSPDGLHVQKIVGDSLENPD--GLVVDSIGRTIYWADAGRHT--I 1324

  Fly  2296 EVCWLDGSNRKVLVKTTTDAPRELAVNPIKRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGISLP 2360
            ||..||||||.|:.....::||.||::....||:|.|:|.:.:|.::.|||::.:.:||:.:..|
  Fly  1325 EVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTANLGWP 1389

  Fly  2361 RDLTIDMQTHDIYWVDSKLDTIQKISYNGANRKIIRRDLPNPMGIAVYLNDVYWVDRNLMTVFKA 2425
            ..|::|:::..|||||::|.||....|.|..||:|...|.:|..:|:..:::||.|.....:...
  Fly  1390 NGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHHPYALALSDDNIYWTDWKSKALHMT 1454

  Fly  2426 SKHSANETATSVRTNLEKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPPDGGASGTSGG 2490
            .:.:.: ....:.||::.|.||.|...|.......|.|.: .||.|..||...|        || 
  Fly  1455 ERRNIS-AKRDIITNIDGLMDIKIIYQNQNQSTMKNACGN-NNGNCSHLCLRNP--------SG- 1508

  Fly  2491 RNFRCECATG-KLSADE-RKCE-VVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNLTNVVGLDF 2552
              :.|:|..| :|..:. .:|: :..:||:.|.|:.|..::|:.........|:..:...|.||:
  Fly  1509 --YSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPINGVHGAVVLDY 1571

  Fly  2553 DFAHNRMLYTQ-----IRPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQQKIYWTDSSN 2612
            .:..|.:.:..     ||....:..|::.       .:|....:.|.|||.||....:||:|:..
  Fly  1572 HYRKNLLFFADVNLDVIRRVNLLNLTESK-------VIVGTDVLTPNGIAVDWIADNLYWSDTDR 1629

  Fly  2613 NSIYAMNLDGS--ELVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAIVD 2675
            ..|....||||  :.::...:..||::::.|....||::||   .:..||.|:.:.||.:..|:.
  Fly  1630 KLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDW---SSPAKIERSYLDGSNRTVIIT 1691

  Fly  2676 KDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATIYPFAITVFRNYIYWTDLQL 2740
            ..:..|:||.||:..|||.|.||:.:.|.:.|.:|:.|:.:|....:||.:|:|.|.|:|||...
  Fly  1692 SGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHPFGLTLFENSIFWTDWYN 1756

  Fly  2741 RGVYRAEK--HTGANMVEMVKRLEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGKAE 2803
            :.|||::|  .:|......|:.......|||..|..||..:||.|..:||||...|... |....
  Fly  1757 KSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLSRQPKSVNHCAQDNGGCTHLCLNR-NVDYV 1820

  Fly  2804 CKCDD 2808
            |.|.|
  Fly  1821 CACPD 1825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_572563.3 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:469594
YncE <492..634 CDD:442618
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:464251
YvrE 854..>992 CDD:442613 1/3 (33%)
LY 922..964 CDD:214531
LY 973..1007 CDD:214531 5/18 (28%)
Ldl_recept_a 1188..1223 CDD:395011 17/34 (50%)
LDLa 1227..1259 CDD:197566 14/31 (45%)
LDLa 1268..1303 CDD:238060 16/43 (37%)
LDLa 1308..1343 CDD:238060 6/34 (18%)
LDLa 1356..1387 CDD:238060 11/30 (37%)
LDLa 1391..1423 CDD:197566 13/31 (42%)
LDLa 1435..1469 CDD:197566 12/38 (32%)
FXa_inhibition 1522..1553 CDD:464251 15/30 (50%)
LY 1625..1665 CDD:214531 16/39 (41%)
LY 1667..1711 CDD:214531 18/43 (42%)
Ldl_recept_b 1690..1729 CDD:459654 22/38 (58%)
LY 1712..1754 CDD:214531 15/41 (37%)
LY 1986..2037 CDD:214531 17/50 (34%)
FXa_inhibition 2151..>2179 CDD:464251 14/27 (52%)
LY 2259..2305 CDD:214531 14/45 (31%)
Ldl_recept_b 2326..2366 CDD:459654 13/39 (33%)
LY 2352..2392 CDD:214531 15/39 (38%)
NHL 2579..>2711 CDD:302697 41/133 (31%)
NHL repeat 2593..2622 CDD:271320 11/28 (39%)
NHL repeat 2634..2678 CDD:271320 13/43 (30%)
LY 2671..2713 CDD:214531 15/41 (37%)
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
FXa_inhibition 3259..3287 CDD:464251
FXa_inhibition 3293..3329 CDD:464251
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
Ldl_recept_b 3468..3511 CDD:459654
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:464251
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4391 CDD:459654
LY 4374..4417 CDD:214531
NHL repeat 4376..4422 CDD:271320
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/33 (52%)
LDLa 306..340 CDD:238060 15/34 (44%)
LDLa 347..390 CDD:238060 16/43 (37%)
LDLa 397..431 CDD:238060 17/78 (22%)
LDLa 442..476 CDD:238060 14/33 (42%)
LDLa 480..521 CDD:238060 14/40 (35%)
FXa_inhibition 576..604 CDD:464251 15/27 (56%)
LY 634..671 CDD:214531 8/36 (22%)
LY 680..714 CDD:214531 14/33 (42%)
LY 718..760 CDD:214531 18/43 (42%)
Ldl_recept_b 740..777 CDD:459654 22/36 (61%)
LY 761..803 CDD:214531 15/41 (37%)
LY 806..838 CDD:214531 16/33 (48%)
FXa_inhibition 882..912 CDD:464251 10/32 (31%)
LY 946..985 CDD:214531 11/51 (22%)
NHL <967..1142 CDD:302697 52/202 (26%)
LY 988..1030 CDD:214531 11/44 (25%)
NHL repeat 998..1037 CDD:271333 12/40 (30%)
NHL repeat 1038..1080 CDD:271333 15/49 (31%)
NHL repeat 1084..1119 CDD:271333 9/34 (26%)
FXa_inhibition 1185..1220 CDD:464251 16/35 (46%)
NHL 1260..>1445 CDD:302697 63/191 (33%)
NHL repeat 1260..1296 CDD:271320 11/38 (29%)
LY 1292..1334 CDD:214531 14/45 (31%)
NHL repeat 1302..1337 CDD:271320 13/38 (34%)
NHL repeat 1345..1383 CDD:271320 13/37 (35%)
FXa_inhibition <1499..1525 CDD:464251 9/36 (25%)
LY 1600..1640 CDD:214531 13/46 (28%)
LY 1643..1686 CDD:214531 12/45 (27%)
LY 1688..1729 CDD:214531 15/40 (38%)
FXa_inhibition 1801..>1825 CDD:464251 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

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