DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment mgl and Lrp4

DIOPT Version :9

Sequence 1:NP_001096924.2 Gene:mgl / 8674055 FlyBaseID:FBgn0261260 Length:4769 Species:Drosophila melanogaster
Sequence 2:NP_727914.1 Gene:Lrp4 / 32552 FlyBaseID:FBgn0030706 Length:2009 Species:Drosophila melanogaster


Alignment Length:1957 Identity:575/1957 - (29%)
Similarity:898/1957 - (45%) Gaps:282/1957 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   988 VYWCDALLDHVQHANLDGTDIKTVNSRLVRHPFSIVIHNDWMYITDWRLDAIIRLHKLTGEQEEM 1052
            |:.|..|.|      |..|.:|........||.:.:...||........||.|...:...|..|.
  Fly    15 VWLCLGLGD------LTKTAVKRNAPHYGIHPTNALGRWDWNKHKQLHSDARIGHLEAGNESRED 73

  Fly  1053 MVREPQT---NRLYGVKVYSHEVQRIADTQPCHRN-NGGCQKICFAVP----------------- 1096
            .:.|..:   .:|:.|..|....|...|:|..|.: .|....:..:||                 
  Fly    74 QLSEELSKFGEKLFPVSNYPPYQQNNEDSQEVHHSGEGRLHTMESSVPSKTRISGGTNSNDTPKF 138

  Fly  1097 --IGASNG---------TDGVTT-----------------------------SSPSFGRLQSRCS 1121
              |||..|         ||.:::                             |.|  |...|.| 
  Fly   139 RNIGAQRGRTEIAGIRETDRISSRGRDGFIGGPSNKQKPFRVNLAVLVQDDPSQP--GETYSNC- 200

  Fly  1122 CPYGERLADDQVSCIPDPSAEPPVQ----------PCPNSWDFTCNNQRCIPKSWLCDGDDDCLD 1176
                :...:...:|.|:..|.|.:|          .||.::       |||.|.|||||||||.|
  Fly   201 ----QNSNESDENCNPEEDAVPNLQRDCEKTGIHVMCPRTF-------RCISKYWLCDGDDDCGD 254

  Fly  1177 NSDEEQNCTKPTCGSNEFQCRSGRCIPQNFRCDQENDCGDNSDEQECGNVTCGTSQFACANGRCI 1241
            .|||.....:..|..::|:|.:|.|||:.:.||.||||.|.|||..|...||....|.|.:|.||
  Fly   255 YSDETHCGARTNCTDDQFECLNGFCIPRTWVCDGENDCKDFSDETHCNRTTCTDEHFTCNDGYCI 319

  Fly  1242 PNMWKCDSENDCGDSSDEGDFCAE--KTCAYFQFTC---------PRTGHCIPQSWVCDGDDDCF 1295
            ...::||.|:||.|:|||.. ||.  .:|...:|.|         | :|.||...:.||||:||.
  Fly   320 SLAFRCDGEHDCNDNSDELK-CAAVINSCPEGEFKCRGGLGGAGGP-SGQCILNRFRCDGDNDCG 382

  Fly  1296 DKQDEKDCP--PISCLANQFKCADLRQCVEESYKCDGIPDCNDGSDEVGCPSMGPNQCNLEKHFR 1358
            |..||::||  |..|.:|::||||                                         
  Fly   383 DWSDEENCPQKPSLCTSNEYKCAD----------------------------------------- 406

  Fly  1359 CKSTGFCIPIAWHCDGSNDCSDHSDEQDCGQ------ITCAQNFFKCNNTNCVFKAYICDGKDDC 1417
                |.|||..|.||...||....||.|||.      :||..:.|.|||..|:.|.::|||..||
  Fly   407 ----GTCIPKRWKCDKEQDCDGGEDENDCGSLGSEHPLTCGSDEFTCNNGRCILKTWLCDGYPDC 467

  Fly  1418 GDNSDEGAEHACVPPPFKCPHGQWQCPGVS-----ERCVNITSVCDDTPDCPNGSDEGEGCDLAE 1477
            ....||...|      .:|..||:.||...     :.||:...:||...:||.|.||.:.....:
  Fly   468 AAGEDEVECH------LQCDLGQFLCPTKQNLTNLKICVHQKHICDGHNECPAGEDEADCPKERK 526

  Fly  1478 CEHQAGQCSSFCQKTPNGA-LCVCPPGSEIGEDGYTCIDSNECD--PPGLCSQQCTNTKGSYFCS 1539
            |. :...|...|.:|..|: .|.|..|..:.::...|.|.:||.  ...:|||:|.||.||:.||
  Fly   527 CS-EPSPCEQLCIETTAGSNECACRLGYVMDKNKVNCTDIDECQYLTSPVCSQKCHNTMGSFKCS 590

  Fly  1540 CTDGYVLEPNKHTCKAVNHTAAFLIISNRHSILVADLKEQGLERVPIIVENVVATASNMHTGTIF 1604
            |..||:|.|:..:|||:. .|..|:::||..|....|.......:...:.|.:|...:...|.:|
  Fly   591 CETGYILRPDLRSCKALG-GAMTLLVANRWDIRRVTLSNNRYSAIVKGLHNAIALDFHHRKGLMF 654

  Fly  1605 WSDMKLKKISRL-DRGMEPQEIINTGLDLVEGLAYDWIAQNLYWLDSKLNTIEVSAENGSNRLVL 1668
            |||:....|..: ..|...:::|..||:...|:|.|||...|:|.||....:|||...|:.|.|:
  Fly   655 WSDVSTDVIKMVYMNGTRVRDVIKWGLESPGGIAVDWIHDLLFWTDSGTRRVEVSNFQGNLRTVI 719

  Fly  1669 VRENITQPRGMCIDPSPGARWIFWTDWGENPRVERIGMDGTMRKTIINTKIYWPNGLTLDIATKR 1733
            ...::.:||.:.:  .||....||:|||.||::||..||||.||.||:..:.|||||.:|....:
  Fly   720 ASYDLDKPRAIVV--HPGEALAFWSDWGPNPKIERAYMDGTQRKVIISKGVTWPNGLAIDFPNSK 782

  Fly  1734 VYFADSKLDFIDFCYYNGTGRQQVLASSHYLLHPHSLSLFEDTLYWTDRQLNRVLSANKFRGKNQ 1798
            :|:||:|...|:....:|:.|.::|  |.:|.||.:|:|||||:||||.....|.:|:|..||..
  Fly   783 IYWADAKQHAIECSNLDGSDRNKIL--STHLPHPFALTLFEDTMYWTDWNTKTVSAADKITGKEF 845

  Fly  1799 TVVSHLISQPLSIHVHHASLQPMTPNPCAGSR------CQHLCLLSPSAPEGYSCKCRPGFKLLS 1857
            ..|......|:.||.:|.:.||...:.|...|      |.||||.:.::..   |.|..|..|..
  Fly   846 RAVHENFHFPMDIHAYHPARQPEYADRCQKDRRGLRGGCSHLCLPNKTSRR---CGCPIGLSLKE 907

  Fly  1858 EGRCIEEENPFLMVV---KGTQIVDLPLNGGDAR-AGALAPVIGIESSTGLDFDRKGETLYWVQG 1918
            :|:..:.....|::|   |..::..|..|..|.. ...:.|:..::.:..||:....:.:||.  
  Fly   908 DGKTCKSTADKLVLVARRKDIRLRHLRDNQADPNDVDMIVPLDNLKHAVALDWCSDTDFIYWT-- 970

  Fly  1919 REDDDENCTIYTTPYGGGNKTLFLG------IENGIVGAPYTIAFDWLGRNLYIGNRVASNIEAV 1977
               |.|..||        ||....|      :.:.:| :|..:|.||:...||..:...:.||..
  Fly   971 ---DVERSTI--------NKAHLNGSYQQRVVHSNLV-SPVGLALDWITDKLYWTDPSTNRIEVA 1023

  Fly  1978 RVDGKQKYRTIILANDGYPNSVSRPKQIALDPTEGKLFWIDEGVLEVPIKIGRVDMNGQNPI-VV 2041
            ..:||.  ||:::....|     :|:.|.::|.||.:||.|.|  :.|: |.|.:|:|...: :.
  Fly  1024 TTNGKM--RTLLIWEKLY-----KPRDIVVNPIEGFMFWSDWG--DDPM-IERANMDGHERVTIT 1078

  Fly  2042 FQEFAHPESLAVDTEKKMVYYSASNPAVIGVMDYNGDDHTLILMKDSHPMAKPRSLGILDHRLYY 2106
            .::..:|..||:|.||..:|:.......:..|:::|....:||....||.    .|.:.:.|:::
  Fly  1079 SKKLIYPNGLAIDYEKSKIYFVDGGTKTLENMNFDGSGRQVILNGLGHPF----GLDVNEGRVFW 1139

  Fly  2107 LDPLYERIVRIDLPHGDNPKTIVDNESDLRSMMIY-KKRALMQHPCQTNNGGCKHLCIPGPGATR 2170
            .|...:.::..:...|.:...|:.|.:||..:.:: :.|..:.:.|...||||.|||:..| .:.
  Fly  1140 TDWDTKSVMSANKLTGKDTNVIIANSTDLMDIRVFHRTRRRIFNACDKLNGGCSHLCLLNP-TSY 1203

  Fly  2171 TCACGIGYR-KENEINC----VAYKIFAVVSQLDMIRGYSLSDSS--EAMVPISGPGHHILHVDV 2228
            ||||.:|.: ||:...|    ..|.:||  .::| ||..||....  :.::|:. |..:.:.:||
  Fly  1204 TCACTVGVQLKEDRHTCSEGPTQYILFA--HRID-IRQISLDFDHLIDVVLPLP-PISNAVALDV 1264

  Fly  2229 MYREQWIYWAEYNRGYWNGIFRSRPNGTDLQHVVKDGIGSNGIRGLTIDWVAGNMYFTNVYPHEN 2293
            ..:..:|||::...   |.|..|.|:|..:|.:|.|.:.:..  ||.:|.:...:|:.:...|. 
  Fly  1265 DRKTGYIYWSDTIE---NVIMSSSPDGLHVQKIVGDSLENPD--GLVVDSIGRTIYWADAGRHT- 1323

  Fly  2294 YVEVCWLDGSNRKVLVKTTTDAPRELAVNPIKRLLYWIDYGQHPRIGKALLDGSKWTPLVTSGIS 2358
             :||..||||||.|:.....::||.||::....||:|.|:|.:.:|.::.|||::.:.:||:.:.
  Fly  1324 -IEVASLDGSNRHVIAYKDLESPRGLALDYEAGLLFWTDWGHYRKIERSHLDGNERSRIVTANLG 1387

  Fly  2359 LPRDLTIDMQTHDIYWVDSKLDTIQKISYNGANRKIIRRDLPNPMGIAVYLNDVYWVDRNLMTVF 2423
            .|..|::|:::..|||||::|.||....|.|..||:|...|.:|..:|:..:::||.|.....:.
  Fly  1388 WPNGLSLDLKSKRIYWVDARLKTIDSCDYTGNQRKLIMSSLHHPYALALSDDNIYWTDWKSKALH 1452

  Fly  2424 KASKHSANETATSVRTNLEKLRDIAIYNINNQPQDDTNPCAHLGNGGCDQLCFSFPPDGGASGTS 2488
            ...:.:.: ....:.||::.|.||.|...|.......|.|.: .||.|..||...|        |
  Fly  1453 MTERRNIS-AKRDIITNIDGLMDIKIIYQNQNQSTMKNACGN-NNGNCSHLCLRNP--------S 1507

  Fly  2489 GGRNFRCECATG-KLSADE-RKCE-VVNEYLVFATRTEIRAVNLDPHSTEVPFTPLTNLTNVVGL 2550
            |   :.|:|..| :|..:. .:|: :..:||:.|.|:.|..::|:.........|:..:...|.|
  Fly  1508 G---YSCQCPIGLRLRQNSTTQCQNLPEDYLLIALRSGIGMISLNSGDFMDVVLPINGVHGAVVL 1569

  Fly  2551 DFDFAHNRMLYTQ-----IRPWAKIAYTKANKPGHDDITVVLNKGINPEGIAYDWTQQKIYWTDS 2610
            |:.:..|.:.:..     ||....:..|::.       .:|....:.|.|||.||....:||:|:
  Fly  1570 DYHYRKNLLFFADVNLDVIRRVNLLNLTESK-------VIVGTDVLTPNGIAVDWIADNLYWSDT 1627

  Fly  2611 SNNSIYAMNLDGS--ELVMIARVERPRAIVLDPCNGTLFFTDWGRFGTSGKIFRTTMAGSLKRAI 2673
            ....|....||||  :.::...:..||::::.|....||::||   .:..||.|:.:.||.:..|
  Fly  1628 DRKLIEVSRLDGSCRKRIVEDNLGDPRSLIVHPKKAYLFWSDW---SSPAKIERSYLDGSNRTVI 1689

  Fly  2674 VDKDLSQPSGLAIDYDERRLYWTDAVREKIERSDLDGQNRELLVAATIYPFAITVFRNYIYWTDL 2738
            :...:..|:||.||:..|||.|.||:.:.|.:.|.:|:.|:.:|....:||.:|:|.|.|:|||.
  Fly  1690 ITSGIGFPTGLTIDFTNRRLLWADALEDNIGQVDFNGKRRQTIVPYAPHPFGLTLFENSIFWTDW 1754

  Fly  2739 QLRGVYRAEK--HTGANMVEMVKRLEDSPRDIRIYSSDRQKCNVNPCRINNGGCAQSCHPAPNGK 2801
            ..:.|||::|  .:|......|:.......|||..|..||..:||.|..:||||...|... |..
  Fly  1755 YNKSVYRSQKLARSGYGNPFEVRDALSGALDIRAVSLSRQPKSVNHCAQDNGGCTHLCLNR-NVD 1818

  Fly  2802 AECKCDD 2808
            ..|.|.|
  Fly  1819 YVCACPD 1825

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mglNP_001096924.2 LDLa 157..189 CDD:238060
LDLa 204..236 CDD:238060
LDLa 292..327 CDD:238060
LDLa 332..366 CDD:238060
LDLa 371..412 CDD:238060
vWFA <447..488 CDD:294047
NHL 573..>716 CDD:302697
NHL repeat 573..610 CDD:271320
NHL repeat 616..654 CDD:271320
NHL repeat 657..693 CDD:271320
FXa_inhibition 763..805 CDD:291342
LY 922..964 CDD:214531
LY 973..1007 CDD:214531 5/18 (28%)
Ldl_recept_a 1188..1223 CDD:278486 17/34 (50%)
LDLa 1227..1259 CDD:197566 14/31 (45%)
LDLa 1268..1303 CDD:238060 16/43 (37%)
LDLa 1308..1343 CDD:238060 6/34 (18%)
LDLa 1356..1387 CDD:238060 11/30 (37%)
LDLa 1391..1423 CDD:197566 13/31 (42%)
LDLa 1435..1469 CDD:197566 12/38 (32%)
FXa_inhibition 1478..1513 CDD:291342 8/35 (23%)
FXa_inhibition 1522..1553 CDD:291342 15/30 (50%)
LY 1625..1665 CDD:214531 16/39 (41%)
LY 1667..1711 CDD:214531 18/43 (42%)
Ldl_recept_b 1690..1728 CDD:278487 22/37 (59%)
LY 1712..1754 CDD:214531 15/41 (37%)
LY 1986..2037 CDD:214531 17/50 (34%)
FXa_inhibition 2151..>2179 CDD:291342 14/27 (52%)
LY 2259..2305 CDD:214531 14/45 (31%)
Ldl_recept_b 2326..2366 CDD:278487 13/39 (33%)
LY 2352..2392 CDD:214531 15/39 (38%)
NHL 2579..>2711 CDD:302697 41/133 (31%)
NHL repeat 2593..2622 CDD:271320 11/28 (39%)
NHL repeat 2634..2678 CDD:271320 13/43 (30%)
LY 2671..2713 CDD:214531 15/41 (37%)
LDLa 2867..2901 CDD:238060
LDLa 2906..2941 CDD:238060
LDLa 2950..2983 CDD:238060
LDLa 3034..3066 CDD:197566
LDLa 3080..3115 CDD:197566
LDLa 3128..3159 CDD:238060
LDLa 3170..3204 CDD:238060
LDLa 3210..3242 CDD:197566
cEGF 3269..3292 CDD:289433
vWFA <3284..3324 CDD:294047
LY 3362..3394 CDD:214531
LY 3406..3448 CDD:214531
LY 3498..3536 CDD:214531
LY 3536..3578 CDD:214531
FXa_inhibition 3607..3659 CDD:291342
LDLa 3663..3696 CDD:238060
LDLa 3705..3739 CDD:238060
LDLa 3743..3775 CDD:197566
LDLa 3784..3817 CDD:197566
LDLa 3827..3861 CDD:197566
LDLa 3871..3901 CDD:197566
LDLa 3913..3947 CDD:238060
LDLa 3952..3986 CDD:238060
LDLa 3996..4027 CDD:197566
LDLa 4043..4071 CDD:238060
LDLa 4086..4117 CDD:238060
EGF_CA 4163..4194 CDD:214542
NHL 4276..>4426 CDD:302697
NHL repeat 4291..4336 CDD:271320
Ldl_recept_b 4350..4390 CDD:278487
NHL repeat 4376..4422 CDD:271320
Lrp4NP_727914.1 LDLa 267..301 CDD:238060 17/33 (52%)
LDLa 306..340 CDD:238060 15/34 (44%)
LDLa 347..390 CDD:238060 16/43 (37%)
LDLa 397..431 CDD:238060 17/78 (22%)
LDLa 442..476 CDD:238060 14/33 (42%)
LDLa 480..521 CDD:238060 14/40 (35%)
FXa_inhibition 576..604 CDD:291342 15/27 (56%)
LY 634..671 CDD:214531 8/36 (22%)
NHL <656..793 CDD:302697 53/138 (38%)
LY 680..714 CDD:214531 14/33 (42%)
NHL repeat 681..722 CDD:271320 16/40 (40%)
NHL repeat 726..760 CDD:271320 17/35 (49%)
LY 761..803 CDD:214531 15/41 (37%)
NHL repeat 769..793 CDD:271320 10/23 (43%)
FXa_inhibition 882..912 CDD:291342 10/32 (31%)
LY 946..985 CDD:214531 11/51 (22%)
NHL <967..1142 CDD:302697 52/202 (26%)
LY 988..1030 CDD:214531 11/44 (25%)
NHL repeat 998..1037 CDD:271320 12/40 (30%)
NHL repeat 1038..1080 CDD:271320 15/49 (31%)
NHL repeat 1084..1119 CDD:271320 9/34 (26%)
FXa_inhibition 1185..1220 CDD:291342 16/35 (46%)
NHL 1260..>1445 CDD:302697 63/191 (33%)
NHL repeat 1260..1296 CDD:271320 11/38 (29%)
NHL repeat 1302..1337 CDD:271320 13/38 (34%)
NHL repeat 1345..1383 CDD:271320 13/37 (35%)
FXa_inhibition <1499..1525 CDD:291342 9/36 (25%)
LY 1600..1640 CDD:214531 13/46 (28%)
LY 1643..1686 CDD:214531 12/45 (27%)
LY 1688..1729 CDD:214531 15/40 (38%)
FXa_inhibition 1801..>1825 CDD:291342 9/24 (38%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45461705
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1215
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100345
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
43.640

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